Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Katherine R. Tuttle, Adeera Levin, Masaomi Nangaku, Takashi Kadowaki, Rajiv Agarwal, Sibylle J. Hauske, Amelie Elsasser, Ivana Ritter, Dominik Steubl, Christoph Wanner, David C. Wheeler
Summary: This study assessed the safety of empagliflozin in patients with type 2 diabetes and moderate to severe chronic kidney disease. The findings showed that empagliflozin did not raise new safety concerns and may have beneficial effects on the development of hyperkalemia and edema.
Review
Medicine, Research & Experimental
Le Deng, Wenjie Li, Gaosi Xu
Summary: Research has identified normoalbuminuric diabetes with renal insufficiency as a distinct phenotype of diabetic kidney disease, characterized by a decline in glomerular filtration rate in the absence of albuminuria. The pathogenesis of this phenotype remains unclear, and there is a need for improvement in the diagnosing process.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Faiez Zannad, Joao Pedro Ferreira, Stuart J. Pocock, Cordula Zeller, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Sibylle Jenny Hauske, Martina Brueckmann, Egon Pfarr, Janet Schnee, Christoph Wanner, Milton Packer
Summary: In the EMPEROR-Reduced trial, empagliflozin treatment had beneficial effects on key efficacy outcomes and slowed the rate of kidney function decline in patients with and without chronic kidney disease, regardless of the severity of kidney impairment at baseline.
Article
Endocrinology & Metabolism
Daishi Hirano, Hiroyuki Unoki-Kubota, Toshiyuki Imasawa, Ritsuko Yamamoto-Honda, Hiroshi Kajio, Shigeo Yamashita, Yuka Fukazawa, Naoto Seki, Mitsuhiko Noda, Yasushi Kaburagi
Summary: In patients with type 2 diabetes with preserved renal function and normoalbuminuria, lower hemoglobin levels were identified as a risk factor for rapid decliners. The study also suggested that disturbed iron metabolism might contribute to the development of rapid renal function decline.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Peripheral Vascular Disease
Young Su Joo, Hyung Woo Kim, Ki Heon Nam, Jee Young Lee, Tae Ik Chang, Jung Tak Park, Tae-Hyun Yoo, Joongyub Lee, Soo Wan Kim, Yun Kyu Oh, Kook-Hwan Oh, Yong-Soo Kim, Curie Ahn, Shin-Wook Kang, Seung Hyeok Han
Summary: In this longitudinal study on CKD, individuals with an increasing SBP trajectory had a significantly higher risk for adverse kidney outcomes compared to those with a stable SBP trajectory, while those with a decreasing SBP trajectory showed a similar risk of adverse kidney outcomes as the stable group.
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Medicine, General & Internal
N. Carlson, K-E Nelveg-Kristensen, E. Freese Ballegaard, B. Feldt-Rasmussen, M. Hornum, A-Lise Kamper, G. Gislason, C. Torp-Pedersen
Summary: This study found an inverse association between estimated glomerular filtration rate and the rate of hospital-diagnosed COVID-19, as well as a progressive increase in the risk of adverse outcomes with decreasing eGFR levels. These results suggest a vulnerability associated with impaired renal function in relation to COVID-19.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Article
Genetics & Heredity
Mohsen Mazidi, Richard Kirwan, Ian G. Davies
Summary: Using Mendelian randomisation analysis, this study found that genetically determined higher blood lead levels are potentially associated with poorer renal function in individuals with type 2 diabetes, highlighting the importance of further research to confirm these results.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Urology & Nephrology
Diego Aguilar Palacios, Brigid Wilson, Mustafa Ascha, Rebecca A. Campbell, Sunah Song, Molly E. DeWitt-Foy, Steven C. Campbell, Robert Abouassaly
Summary: The study developed and validated a simplified equation to predict new baseline glomerular filtration rate in patients with renal cell carcinoma undergoing radical nephrectomy or partial nephrectomy. The equation demonstrated high correlation and accuracy in both internal and external validation cohorts, accurately predicting postoperative glomerular filtration rate above a certain threshold.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Meghann Pasternak, Ping Liu, Robert Quinn, Meghan Elliott, Tyrone Gorden Harrison, Brenda Hemmelgarn, Ngan Lam, Paul Ronksley, Marcello Tonelli, Pietro Ravani
Summary: This study aims to assess the 5-year probability of CKD regression in patients with newly diagnosed CKD, taking into account the competing risks of CKD progression and death, and investigate the association between albuminuria level and CKD regression.
Article
Clinical Neurology
Rocco Hoekstra, Marius N. Lekkerkerker, Tjallingius M. Kuijper, Tessa M. Bosch, Arjan M. van Alphen
Summary: Discontinuation of lithium medication can lead to improvement in renal function or at least slow down the rapid deterioration in the majority of patients.
Article
Endocrinology & Metabolism
Pierre J. Saulnier, Helen C. Looker, Michael Mauer, Behzad Najafian, Elise Gand, Stephanie Ragot, Robert G. Nelson, Petter Bjornstad
Summary: In patients with type 2 diabetes, intraglomerular hemodynamic parameters are strongly associated with incident end-stage kidney disease (ESKD) and correlate with structural lesions of diabetic kidney disease (DKD).
Article
Urology & Nephrology
Hyo-Sun You, Sang-Jun Shin, Joungyoun Kim, Hee-Taik Kang
Summary: Dyslipidemia is a known risk factor for chronic kidney disease (CKD). However, the use of statins in patients with hypercholesterolemia and normal renal function does not show a clear relationship with the incidence of CKD.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Peripheral Vascular Disease
Kiminori Kato, Tomoaki Ishigami, Takashi Kobayashi, Minoru Tahiro, Shigemi Tashiro, Takaho Yamada, Midori Iwanaga, Satoru Kodama, Kazuya Fujihara, Koji Sato, Hirohito Sone
Summary: Salt excretion using spot urine (e-NaCl) is a convenient method to determine salt intake. In this study, e-NaCl was measured during health checkups and compared with seasonal changes in blood pressure. The results showed that e-NaCl decreased in summer, possibly due to reduced burden on the kidneys for salt excretion caused by sweating, which may be related to decreases in blood pressure.
HYPERTENSION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Yuta Yaguchi, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study aimed to investigate the associations between urinary protein and reduced glomerular filtration rate (eGFR) and the risk of starting dialysis. The results showed that the severity of urinary protein and eGFR were independent predictors of starting dialysis, and the risk was higher in individuals with diabetes mellitus.
DIABETOLOGY INTERNATIONAL
(2023)
Article
Peripheral Vascular Disease
Ayako Kobayashi, Kazuya Fujihara, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study investigated the combined effects of blood pressure and glycemic status on the risk of heart failure using a Japanese claims database. The results showed that the relationship between blood pressure and heart failure risk weakened with worsening of glucose metabolism. In patients with diabetes, comprehensive management of risk factors other than blood pressure may be essential to prevent heart failure.
JOURNAL OF HYPERTENSION
(2023)
Review
Medicine, General & Internal
Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Yasuhiro Matsubayashi, Masaru Kitazawa, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Yoshimi Nakagawa, Shiro Tanaka, Hitoshi Shimano, Hirohito Sone
Summary: This network meta-analysis aimed to find optimal glucose-lowering drug treatment regimens in terms of glycemic control and hypoglycemia risk for patients with type 2 diabetes. The use of insulin and non-insulin glucose-lowering agents showed better glycemic control and lower risk of hypoglycemia. Certain combinations of insulin and non-insulin agents were identified as high-efficacy and relatively high-efficacy options for glycemic control. Clinicians should consider appropriate combinations of non-insulin agents to reduce hypoglycemia risk before switching to insulin therapies and be willing to add non-insulin agents to insulin for further improvement in glycemic control.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Kazuya Fujihara, Laymon Khin, Koshiro Murai, Yurie Yamazaki, Kahori Tsuruoka, Noriko Yagyuda, Katsuya Yamazaki, Hiroshi Maegawa, Shiro Tanaka, Satoru Kodama, Hirohito Sone
Summary: This study aimed to determine the incidence of remission and 1-year relapse in patients with type 2 diabetes and associated factors. The overall incidence of remission in Japanese patients was 10.5 per 1000 person-years, with higher rates for those with HbA1c levels of 48 to 53 mmol/mol (6.5% to 6.9%), those taking no glucose-lowering drugs at baseline, and those with a =10% BMI reduction in 1 year. Shorter duration, lower baseline HbA1c, higher baseline BMI, greater BMI reduction at 1 year, and no glucose-lowering drugs at baseline were significantly associated with remission. Among those with remission, approximately two-thirds relapsed within 1 year. Longer duration, lower baseline BMI, and lower BMI reduction at 1 year were significantly associated with relapse.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Yuhki Sakurai, Nobumasa Ohara, Yumi Fukai, Yasuhiro Seki, Katsuhiko Akiyama, Yuichiro Yoneoka, Toshinori Takada, Takashi Tani, Kenshi Terajima, Tetsutaro Ozawa, Hirohito Sone
Summary: A 56-year-old man with anorexia for 2.5 months presented with sweating, weakness, left hemiplegia, and hemispatial neglect. Magnetic resonance imaging showed no abnormalities, but magnetic resonance angiography revealed narrowing of the right middle cerebral artery. Neurological symptoms and arterial narrowing resolved after correction of hypoglycemia. Adrenal insufficiency was identified through endocrinological examinations. Hemiplegia is a rare but important neurological manifestation of hypoglycemia, possibly caused by combined hypoglycemia and decreased blood flow leading to regional neuroglycopenia and ischemia.
Article
Sport Sciences
Takaaki Sato, Kazuya Fujihara, Mayuko Harada Yamada, Kaori Chou, Yuta Yaguchi, Masaru Kitazawa, Hajime Ishiguro, Taeko Osawa, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: A new Physical Score (PS) was developed and its association with metabolic diseases among Japanese individuals was elucidated. The PS was calculated based on physical fitness indicators and showed a significant association with an increased risk of metabolic diseases, especially metabolic syndrome. The PS was found to be a useful and simple non-invasive tool for screening Japanese people for metabolic diseases.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hirohito Sone
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Kazuya Fujihara, Hirohito Sone
Summary: Globally, the number of people with diabetes mellitus has increased by four times in the past 30 years, and approximately one in 11 adults worldwide have diabetes mellitus. Managing blood glucose levels is crucial for diabetes care due to its impact on the quality of life and mortality rates of the patients. Various classes of antihyperglycemic drugs are available, but the application of clinical trial results to actual clinical practice is challenging. Machine learning approaches in drug treatment strategies for diabetes care have been slow to be adopted.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Kazuya Fujihara, Mayuko Yamada Harada, Chika Horikawa, Midori Iwanaga, Hirofumi Tanaka, Hitoshi Nomura, Yasuharu Sui, Kyouhei Tanabe, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: This study developed a machine learning model to predict weight change over three years. It found that lifestyle had a significant impact on weight in individuals with high BMI and in young people. The model showed comparable accuracy to multiple regression, suggesting its potential for personalized weight management.
FRONTIERS IN PUBLIC HEALTH
(2023)
Correction
Nutrition & Dietetics
Kanako Sumi, Yuiko Hatanaka, Reina Takahashi, Naoko Wada, Chihiro Ono, Yuri Sakamoto, Hirohito Sone, Kaoruko Iida
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Kazuya Fujihara, Laymon Khin, Koshiro Murai, Yurie Yamazaki, Kahori Tsuruoka, Noriko Yagyuda, Katsuya Yamazaki, Hiroshi Maegawa, Shiro Tanaka, Satoru Kodama, Hirohito Sone, DDM Study Grp
Summary: This study found an association between the magnitude of weight loss and the incidence of remission in patients with diabetes. Significant weight loss is required, with at least 10% reduction, to achieve a 10% remission rate in clinical settings.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hiroki Yokoyama, Shin-ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Hajime Maeda, Masafumi Ohtaki, Hiromi Obata, Hirohito Sone, Daijiro Kabata, Ayumi Shintani, Hiroshi Maegawa, JDDM Study Group
Summary: This study aimed to investigate the reduction in all-cause mortality and cardiovascular disease morbidity in type 2 diabetes patients over the past decade in real-world practice. The results showed a significant reduction in cardiovascular disease in the recent cohort, implying the impact of treatment advances.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Meeting Abstract
Peripheral Vascular Disease
Kiminori Kato, Tomoaki Ishigami, Hirohito Sone
JOURNAL OF HYPERTENSION
(2023)
Article
Primary Health Care
Haruka Shiozaki, Kazuya Fujihara, Mayuko Yamada-Harada, Masahiko Yamamoto, Yurie Mitsuma, Masaru Kitazawa, Yuta Yaguchi, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study aimed to investigate the independent associations of fast walking and habitual physical activity with the incidence of functional disability. The results showed that the absence of habitual physical activity and inability to walk fast were both significant risk factors for functional disability. Furthermore, the impact of these factors on disability risk varied according to age.