Article
Urology & Nephrology
Oriol Cunillera-Puertolas, David Vizcaya, M. Jesus Cerain-Herrero, Neus Gil-Terron, Silvia Cobo-Guerrero, Betlem Salvador-Gonzalez
Summary: In patients with CKD, a prior diagnosis of HTN and/or T2D increases the risk of cardiovascular events and mortality.
Editorial Material
Cardiac & Cardiovascular Systems
Merrill Thomas, Melissa Magwire, Kensey Gosch, Yasser Sammour, Rane Mehta, James O'Keefe, Michael E. Nassif, Mikhail Kosiborod
Summary: Additional digital content is available within the text.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2021)
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Lingwang An, Qiuzhi Yu, Hong Tang, Xianglan Li, Dandan Wang, Qi Tang, Haiyang Xing, Yali He, Xiaona Zhao, Shuhui Zhao, Yaujiunn Lee, Juming Lu
Summary: This study evaluated the prevalence of chronic kidney disease (CKD) in Chinese adults with type 2 diabetes mellitus (T2DM) and investigated the association between ABC control (HbA(1c), blood pressure, and triglycerides) and the progression and regression of CKD. The results showed a high prevalence of CKD and a certain percentage of patients had an increased risk of CKD progression. The study also found a negative association between ABC control and CKD progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Stefan D. Anker, Rajiv Agarwal, Bertram Pitt, Luis M. Ruilope, Peter Rossing, Peter Kolkhof, Patrick Schloemer, Ingo Tornus, Amer Joseph, George L. Bakris
Summary: The FIDELIO-DKD trial demonstrated that Finerenone reduced the incidence of cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes, with a composite outcome including cardiovascular death, myocardial infarction, stroke, and hospitalization for heart failure. There was no difference in the treatment effect based on preexisting cardiovascular disease status, with similar incidence of adverse events between treatment arms.
Article
Cardiac & Cardiovascular Systems
Nan Ye, Meg J. Jardine, Megumi Oshima, Carinna Hockham, Hiddo J. L. Heerspink, Rajiv Agarwal, George Bakris, Aletta E. Schutte, Clare Arnott, Tara I. Chang, Jose L. Gorriz, Christopher P. Cannon, David M. Charytan, Dick de Zeeuw, Adeera Levin, Kenneth W. Mahaffey, Bruce Neal, Carol Pollock, David C. Wheeler, Gian Luca Di Tanna, Hong Cheng, Vlado Perkovic, Brendon L. Neuen
Summary: The study demonstrates that canagliflozin lowers systolic blood pressure in patients with type 2 diabetes and chronic kidney disease, reduces the need for additional blood pressure-lowering agents, and shows consistent effects across various systolic blood pressure levels and antihypertensive therapy subgroups.
Review
Pharmacology & Pharmacy
Vijayvardhan Kamalumpundi, Elham Shams, Cally Tucker, Linhai Cheng, Joshua Peterson, Sanmati Thangavel, Oloigbe Ofori, Marcelo Correia
Summary: Type 2 diabetes often overlaps with hypertension due to genetic, physiological, and environmental factors. There are several metabolic abnormalities that contribute to the coexistence. While diet and exercise are early treatment options, long-term strategies are needed. Novel medications can prevent long-term complications. Understanding the common causes and consequences allows for proactive prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Katarzyna Dziopa, Folkert W. Asselbergs, Jasmine Gratton, Nishi Chaturvedi, Amand F. Schmidt
Summary: This study aimed to compare the performance of risk prediction scores for cardiovascular disease (CVD) in individuals with type 2 diabetes. The Systemic Coronary Risk Evaluation (SCORE) CVD rule derived in the general population performed best for both CVD and a broader definition of CVD. Simple recalibration considerably improved the performance of the scores.
Review
Endocrinology & Metabolism
Hyun-Jin Kim, Kwang-il Kim
Summary: This review discusses the optimal blood pressure targets for patients with diabetes mellitus and summarizes the recommendations from different guidelines. A target blood pressure of <140/90 mm Hg is recommended, and <130/80 mm Hg for patients with diabetes mellitus who have high-risk clinical features.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Endocrinology & Metabolism
Wei-Ren Lin, Kuan-Hung Liu, Tsai-Chieh Ling, Ming-Cheng Wang, Wei-Hung Lin
Summary: Insulin resistance is a condition where target tissues have a diminished response to insulin, resulting in impaired glucose uptake and elevated blood sugar levels. This can lead to beta cell dysfunction and ultimately the development of type 2 diabetes mellitus. Insulin resistance is also associated with cardiovascular disease and is common in patients with chronic kidney disease. The mechanisms of insulin resistance in CKD are complex and include factors such as physical inactivity, inflammation, metabolic acidosis, and vitamin D deficiency. Various anti-diabetic medications have different effects on insulin resistance. This review discusses the potential mechanisms of insulin resistance in CKD patients and the interaction of current anti-diabetic medications with insulin resistance.
WORLD JOURNAL OF DIABETES
(2023)
Article
Hematology
Emelie Curovic Rotbain, Cristine Allmer, Klaus Rostgaard, Michael Asger Andersen, Noomi Vainer, Caspar da Cunha-Bang, Sameer A. Parikh, Kari G. Rabe, Henrik Hjalgrim, Henrik Frederiksen, Susan L. Slager, Carsten Utoft Niemann
Summary: Age-related comorbid conditions, such as type 2 diabetes, are common in patients with chronic lymphocytic leukemia (CLL). This study analyzed two separate cohorts to assess the impact of type 2 diabetes on CLL patient outcomes. The results showed that CLL patients with type 2 diabetes had shorter overall survival, were less likely to receive treatment, and had an increased risk of death due to infections. These findings highlight the need for additional interventions and research to address the treatment needs of CLL patients with co-occurring type 2 diabetes.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Nikita Stempniewicz, Joseph A. Vassalotti, John K. Cuddeback, Elizabeth Ciemins, Amy Storfer-Isser, Yingying Sang, Kunihiro Matsushita, Shoshana H. Ballew, Alex R. Chang, Andrew S. Levey, Robert A. Bailey, Jesse Fishman, Josef Coresh
Summary: The study found that eGFR testing rates are generally high among people with type 2 diabetes in the U.S., but testing rates for uACR are suboptimal and vary significantly across different organizations and clinical practice sites. Increasing guideline-recommended uACR testing could enhance the detection of chronic kidney disease (CKD) in this population.
Article
Endocrinology & Metabolism
Peter P. Harms, Amber A. van der Heijden, Femke Rutters, Hanno L. Tan, Joline W. J. Beulens, Giel Nijpels, Petra Elders
Summary: The study revealed a high prevalence of resting ECG abnormalities in individuals with type 2 diabetes, including those without a history of cardiovascular disease. These abnormalities were consistently associated with traditional cardiovascular risk factors.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study investigated changes in cardiovascular dynamics, adipose tissue, and kidney pathology associated with obesity and T2D in ZFDM rats. The results showed that heart rate and plasma adrenaline concentration decrease with the progression of obesity and T2D in ZFDM rats. In addition, inflammation occurs in perirenal white adipose tissue, while degeneration and whitening occur in interscapular brown adipose tissue. Furthermore, renal function is impaired. ZFDM rats will be useful for studying metabolic changes associated with obesity and T2D progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Maurizio Nordio, Gianpaolo Reboldi, Anteo Di Napoli, Giuseppe Quintaliani, Federico Alberici, Maurizio Postorino, Filippo Aucella, Piergiorgio Messa, Giuliano Brunori
Summary: The study found that the increased positivity among hemodialysis patients was associated with center location, positive healthcare workers, test-all policy, and infected proportion in the general population. The protective effect of lockdown duration was also identified. Factors predicting peritoneal dialysis and transplant cases included center location and infected proportion in the general population.
JOURNAL OF NEPHROLOGY
(2021)
Article
Rheumatology
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A. Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Matteo d'Alessandro, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri
Summary: The circulating anti-ENO1, anti-H2A, and anti-ANXA1 antibodies were associated with high proteinuria in lupus nephritis patients, with the anti-ENO1 antibody showing the maximum reduction within 12 months paralleling the decrease in proteinuria. Anti-dsDNA antibodies were not linked to renal outcome parameters. New IgG2 antibody signatures have the potential to be used as markers for personalized therapies in lupus nephritis.
Article
Rheumatology
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A. Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Stefano Volpi, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri
Summary: This study demonstrated the potential of IgG2 antibodies in serum to differentiate between SLE/LN and other rheumatologic conditions. The IgG2 antibodies against dsDNA and C1q showed higher sensitivity than IgGs in identifying SLE patients, while IgG2 antibodies against ENO1 and H2A were found to be valuable in discriminating between LN and SLE.
Article
Nutrition & Dietetics
Carla Maria Avesani, Alice Sabatino, Alessandro Guerra, Juliana Rodrigues, Juan Jesus Carrero, Giovanni Maria Rossi, Giacomo Garibotto, Peter Stenvinkel, Enrico Fiaccadori, Bengt Lindholm
Summary: This study evaluated the performance of GLIM in identifying malnutrition in MHD patients, and found that it had low agreement, sensitivity, and accuracy compared to 7p-SGA and MIS. The well-established 7p-SGA and MIS methods may be more useful in this clinical setting, considering the specific wasting characteristics in MHD.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Urology & Nephrology
Angela Yee-Moon Wang, Ikechi G. Okpechi, Feng Ye, Csaba P. Kovesdy, Giuliano Brunori, Jerrilynn D. Burrowes, Katrina Campbell, Sandrine Damster, Denis Fouque, Allon N. Friedman, Giacomo Garibotto, Fitsum Guebre-Egziabher, David Harris, Kunitoshi Iseki, Vivekanand Jha, Kailash Jindal, Kamyar Kalantar-Zadeh, Brandon Kistler, Joel D. Kopple, Martin Kuhlmann, Meaghan Lunney, Denise Mafra, Charu Malik, Linda W. Moore, S. Russ Price, Alison Steiber, Christoph Wanner, Pieter ter Wee, Adeera Levin, David W. Johnson, Aminu K. Bello
Summary: This study investigated the availability of kidney nutrition care services and interdisciplinary communication on a global scale. The results revealed significant gaps in service capacity, availability, cost coverage, and interdisciplinary communication, especially in lower-income countries.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Editorial Material
Immunology
Francesco Lapi, Ettore Marconi, Pier Mannuccio Mannucci, Claudio Cricelli
EXPERT REVIEW OF VACCINES
(2022)
Article
Immunology
Francesco Lapi, Alexander Domnich, Ettore Marconi, Alessandro Rossi, Ignazio Grattagliano, Erik Lagolio, Gerardo Medea, Aurelio Sessa, Iacopo Cricelli, Giancarlo Icardi, Claudio Cricelli
Summary: This study developed and validated a prognostic index for GPs to prioritize COVID-19 patients for preventive and therapeutic interventions, showing a high accuracy in predicting severe outcomes.
EXPERT REVIEW OF VACCINES
(2022)
Article
Cardiac & Cardiovascular Systems
Sandhya S. Thomas, Jiao Wu, Giovanni Davogustto, Michael W. Holliday, Kristin Eckel-Mahan, Daniela Verzola, Giacomo Garibotto, Zhaoyong Hu, William E. Mitch, Heinrich Taegtmeyer
Summary: The study reveals the important role of SIRP alpha protein in CKD-induced adverse cardiac remodeling by impairing insulin/IGF1R signaling, leading to myocardial dysfunction and fibrosis.
CIRCULATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Gianluca Gortan Cappellari, Annamaria Semolic, Giulia Ruozi, Davide Barbetta, Francesca Bortolotti, Pierandrea Vinci, Michela Zanetti, Robert H. Mak, Giacomo Garibotto, Mauro Giacca, Rocco Barazzoni
Summary: The study investigated the impact of n3-polyunsaturated fatty acids (n3-PUFA) in the diet on skeletal muscle mitochondrial function in chronic kidney disease (CKD). The results showed that n3-PUFA can normalize mitochondrial master-regulators, ATP production, and dynamics, as well as regulate ROS production through enhanced mitophagy. These effects may protect against muscle wasting and have a potential positive impact on patient survival.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Elisa Russo, Maria Bertolotto, Valentina Zanetti, Daniela Picciotto, Pasquale Esposito, Federico Carbone, Fabrizio Montecucco, Roberto Pontremoli, Giacomo Garibotto, Francesca Viazzi, Daniela Verzola
Summary: This study demonstrates that uric acid (UA) can induce changes in VSMC cytoskeleton, leading to increased cell migration and activation of specific signaling pathways. These findings suggest that UA may play a critical role in vascular remodeling, emphasizing the importance of interventions to prevent the development of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Giacomo Garibotto, Daniela Picciotto, Pasquale Esposito
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Pasquale Esposito, Daniela Verzola, Michela Saio, Daniela Picciotto, Marco Frascio, Alessandro Laudon, Valentina Zanetti, Giuliano Brunori, Giacomo Garibotto, Francesca Viazzi
Summary: Protein energy wasting (PEW) is a common complication in chronic kidney disease (CKD) and end-stage kidney disease (ESKD), and it is strongly associated with morbidity and mortality in these patient populations. The pathogenesis of PEW involves various mechanisms such as anorexia, insulin resistance, acidosis, low-grade inflammation, and sterile muscle inflammation at advanced CKD stages. Immune and resident muscle cells play critical roles in triggering sterile tissue inflammation through innate immunity pathways, including toll-like receptor 4 (TLR4) activation and NLRP3 inflammasome signaling. Targeting these innate immune pathways could potentially lead to novel therapies for CKD-related PEW.
Article
Physiology
Giacomo Garibotto, Daniela Picciotto, Daniela Verzola, Alessando Valli, Antonella Sofia, Francesca Costigliolo, Michela Saio, Francesca Viazzi, Pasquale Esposito
Summary: This study investigated the exchange of homocysteine (Hcy) in the forearm in patients with chronic kidney disease (CKD) and those undergoing hemodialysis (HD). The results showed that Hcy levels in the deep forearm vein were consistently higher than the arterial levels, indicating Hcy release from muscle. The release of Hcy from the forearm was similar among all groups, and folate was identified as a major determinant of Hcy release.
PHYSIOLOGICAL REPORTS
(2023)
Article
Medicine, General & Internal
Giovan Battista Ruffo, Rodolfo Russo, Tommaso Casini, Letizia Lombardini, Valeria Orecchia, Vincenzo Voi, Raffaella Origa, Gian Luca Forni, Monia Marchetti, Antonia Gigante, Giacomo Garibotto, Aurelio Maggio, Lucia De Franceschi
Summary: This article reviews the literature on kidney alterations and kidney diseases in patients with hemoglobinopathies, and provides recommendations for follow-up and therapy. The importance of improving clinical management and the quality of care is emphasized.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Dilushi R. Wijayaratne, Lauren Heptinstall, Giacomo Garibotto, Daniela Verzola, Gabriele Gaggero, Angelica Parodi, Ruth J. Pepper
Summary: Two young women in their 20s with antiphospholipase A2 receptor (anti-PLA(2)R)-negative membranous nephropathy (MN) were found to have benign tumors. Both women had no extrarenal symptoms and were previously healthy. Kidney biopsies showed MN without the presence of anti-PLA(2)R antibodies. Radioimaging revealed uterine leiomyoma and mesenteric fibromatosis in the two cases, respectively. The nephrotic syndrome remitted after tumor resection.