Article
Medicine, General & Internal
Sabrina Stern, Dmitri Bezinover, Peter-M. Rath, Andreas Paul, Fuat H. Saner
Summary: Fungal contamination in preservation solutions of renal and hepatic grafts was low but associated with high mortality. Candida infections may lead to severe complications, including peritonitis and candidemia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kenji Matsui, Yoshitaka Kinoshita, Yuka Inage, Naoto Matsumoto, Keita Morimoto, Yatsumu Saito, Tsuyoshi Takamura, Hitomi Matsunari, Shuichiro Yamanaka, Hiroshi Nagashima, Eiji Kobayashi, Takashi Yokoo
Summary: Fetal porcine kidneys injected with human nephron progenitor cells could be a viable option for kidney transplantation; using a model of freezing and transplantation, we demonstrated that the differentiation potency of vitrified fetal porcine kidneys could be evaluated, providing a practical protocol to assess the quality of individual lots.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Maryne Lepoittevin, Sebastien Giraud, Thomas Kerforne, Benoit Barrou, Lionel Badet, Petru Bucur, Ephrem Salame, Claire Goumard, Eric Savier, Julien Branchereau, Pascal Battistella, Olaf Mercier, Sacha Mussot, Thierry Hauet, Raphael Thuillier
Summary: Organ transplantation is the last resort for treating organ failure, but the shortage of organs remains a challenge. To address this issue, there is a need to expand the donor pool and optimize preservation conditions to improve the quality of transplanted organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Irene Bellini, Francesco Tortorici, Maria Ida Amabile, Vito D'Andrea
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease, with static cold storage being the standard preservation method. However, dynamic techniques like machine perfusion have shown potential to improve graft function and quality assessment, particularly in kidneys from extended criteria donors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aneta Ostrozka-Cieslik
Summary: This article discusses the clinical problem of ischemia-reperfusion injury and the direction for improving preservation solutions. It presents clinical and experimental studies aimed at optimizing these fluids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Wei Kelly Wu, Rei Ukita, Yatrik J. Patel, Michael Cortelli, Vincent Q. Trinh, Ioannis A. Ziogas, Sean A. Francois, Meredith Mentz, Nancy L. Cardwell, Jennifer R. Talackine, William M. Grogan, John W. Stokes, Youngmin A. A. Lee, Jinho Kim, Sophoclis P. Alexopoulos, Matthew Bacchetta
Summary: Xenogeneic cross-circulation technique has been successfully used to support and rehabilitate declined donor livers, resulting in preservation of organ structure and function, improved viability markers, and potential for further research in organ recovery and rehabilitation.
Review
Urology & Nephrology
Asel S. Arykbaeva, Dorottya K. de Vries, Jason B. Doppenberg, Marten A. Engelse, Thomas Hankemeier, Amy C. Harms, Leonie G. Wijermars, Alexander F. Schaapherder, Jaap A. Bakker, Rutger J. Ploeg, Ian P. J. Alwayn, Jan H. N. Lindeman
Summary: Normothermic machine perfusion (NMP) is a novel preservation strategy that maintains organs in a metabolically active state, providing superior organ preservation and allowing viability testing before transplantation. However, current perfusion protocols may not fully address the metabolic requirements of marginal donor grafts. Monitoring of metabolic status during NMP is important for optimal outcomes.
KIDNEY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Tom Darius, Jay Nath, Michel Mourad
Summary: The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes and decrease organ discard rate. Oxygenation during hypothermic machine preservation is proposed as a resuscitative measure, providing a critical overview of the fundamentals and suggesting different strategies for clinical implementation.
Article
Gastroenterology & Hepatology
Hiroyoshi Iwata, Naoto Matsuno, Daisuke Ishii, Asuka Toriumi, Masahide Otani, Mizuho Ohara, Hiromichi Obara, Yuji Nishikawa, Hideki Yokoo
Summary: This study compared the use of University of Wisconsin solution and histidine-tryptophan-ketoglutarate solution as machine perfusion solutions for marginal liver grafts. The results showed that histidine-tryptophan-ketoglutarate solution can decrease vascular resistance, reduce shear stress, and protect sinusoid epithelial cells in split-liver grafts.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Sudanthi Wijewickrema, Christofer Bester, Jean-Marc Gerard, Aaron Collins, Stephen O'Leary
Summary: Cochlear implants (CIs) offer the hearing impaired a chance to perceive sound through electrical stimulation of the cochlear nerve. However, CI surgery carries a high risk of losing natural hearing, which can impact speech perception and music appreciation. Electrocochleography (ECochG) has been used to detect trauma during surgery and potentially save natural hearing. This study discusses an automated method for analyzing cochlear responses during CI surgeries, demonstrating high accuracy compared to human experts and the potential to improve ECochG scalability and patient safety.
Article
Surgery
Dieter P. Hoyer, Tamas Benkoe, Anja Gallinat, Rolf Lefering, Moritz Kaths, Andreas Kribben, Johannes Korth, Ursula Rauen, Juergen W. Treckmann, Andreas Paul
Summary: HTK-N, developed from traditional HTK solution, showed comparable effectiveness with HTK in clinical kidney transplantation, demonstrating no significant differences in primary and secondary endpoints, indicating non-inferiority of HTK-N in living donor kidney transplantation.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Yin-Chin Wang, Ming-Jiuh Wang, Chih-Yuan Lee, Chien-Chia Chen, Ching-Tang Chiu, Anne Chao, Wing-Sum Chan, Meng-Kun Tsai, Yu-Chang Yeh
Summary: This study investigated the effect of dexmedetomidine on postoperative renal function and sublingual microcirculation in kidney transplant recipients. The results showed that early postoperative renal function was better in kidney transplant recipients receiving dexmedetomidine infusion, but total vessel density was not significantly different between the intervention and control groups.
ANNALS OF MEDICINE
(2022)
Review
Medicine, General & Internal
Julie De Beule, Delphine Keppens, Hannelie Korf, Ina Jochmans
Summary: There is uncertainty about the composition of the perfusate for normothermic kidney perfusion, and the effect of different perfusate components or ischemic conditions on cytokine levels is unclear. Further research is needed to understand the role of leukocyte filters and the changes in cytokine levels during different ischemic conditions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Kotaro Nishi, Satomi Iwai, Kazuki Tajima, Shozo Okano, Motoaki Sano, Eiji Kobayashi
Summary: This study confirmed the effectiveness of using hydrogen gas treatment in preserving marginal kidneys and carrying out transplantation with a strict immunosuppressive protocol to alleviate chronic rejection. Long-term results were favorable, with most cases showing no signs of chronic rejection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eileen Edgworth, Lisa Ernst, Zoltan Czigany, Turgay Saritas, Laura Sophie Zarnitz, Marc Wiartalla, Peter Boor, Eva Miriam Buhl, Rolf Rossaint, Rene H. Tolba, Benedict Doorschodt, Gregor Fabry, Christian Bleilevens
Summary: Normothermic machine perfusion (NMP) combined with optimized perfusate composition can improve the quality of kidney preservation, but the optimization of perfusates is still under research. Hemoglobin-based oxygen carriers (HBOCs), such as HBOC-301, can be an alternative to packed red blood cells (pRBC), but they can cause methemoglobin formation and induce hypoxia. The addition of ascorbic acid (VitC) as an antioxidant may have a beneficial effect. This study showed that HBOC-301 is inferior to pRBCs in a porcine kidney NMP model, regardless of the addition of VitC. Oxidative stress and fragmentation of hemoglobin polymers may contribute to these results, indicating the need for further research on cell-free oxygen carriers without these issues.
Article
Cell Biology
Maaike Waasdorp, Dennis M. de Rooij, Sandrine Florquin, JanWillem Duitman, C. Arnold Spek
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll, Alex F. de Vos
MOLECULAR MEDICINE
(2019)
Article
Pediatrics
Aysenur Demirok, Claudia Ranzijn, Junior Lardy, Sandrine Florquin, Antonia Bouts
PEDIATRIC TRANSPLANTATION
(2019)
Editorial Material
Urology & Nephrology
Eric Rondeau, Valerie A. Luyckx, Hans-Joachim Anders, Kai-Uwe Eckardt, Sandrine Florquin, Hans-Peter Marti, Klaus Olgaard, Paul Harden
KIDNEY INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Angelique M. L. Scantlebery, Melissa Uil, Loes M. Butter, Renee Poelman, Nike Claessen, Stephen E. Girardin, Sandrine Florquin, Joris J. T. H. Roelofs, Jaklien C. Leemans
Article
Hematology
Alexander P. N. A. de Porto, Theodora A. M. Claushuis, Lieve E. H. van der Donk, Regina de Beer, Onno J. de Boer, Sandrine Florquin, Ions J. T. H. Roelofs, Rudi W. Hendriks, Tom van Der Poll, Cornelis van't Veer, Alex F. de Vos
THROMBOSIS AND HAEMOSTASIS
(2019)
Article
Immunology
Yassine Bouatou, Tri Q. Nguyen, Joris J. T. H. Roelofs, Frederike J. Bemelman, Laura Michielsen, Roel Goldschmeding, Jesper Kers, Sandrine Florquin
Correction
Multidisciplinary Sciences
Melissa Uil, Angelique M. L. Scantlebery, Loes M. Butter, Per W. B. Larsen, Onno J. de Boer, Jaklien C. Leemans, Sandrine Florquin, Joris J. T. H. Roelofs
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Marcel P. B. Jansen, Andras Huisman, Nike Claessen, Sandrine Florquin, Joris J. T. H. Roelofs
Article
Urology & Nephrology
Meyke Hermsen, Thomas de Bel, Marjolijn den Boer, Eric J. Steenbergen, Jesper Kers, Sandrine Florquin, Joris J. T. H. Roelofs, Mark D. Stegall, Mariam P. Alexander, Byron H. Smith, Bart Smeets, Luuk B. Hilbrands, Jeroen A. W. M. van der Laak
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Cell & Tissue Engineering
Desiree Perlee, Alex F. de Vos, Brendon P. Scicluna, Anja Maag, Pablo Mancheno, Olga de la Rosa, Wilfried Dalemans, Sandrine Florquin, Cornelis van't Veer, Eleuterio Lombardo, Tom van der Poll
STEM CELL RESEARCH & THERAPY
(2019)
Article
Medicine, General & Internal
Floor Veltkamp, Djera H. Khan, Christa Reefman, Susan Veissi, Hedy A. van Oers, Elena Levtchenko, Ron A. A. Mathot, Sandrine Florquin, Joanna A. E. van Wijk, Michiel F. Schreuder, Lotte Haverman, Antonia H. M. Bouts
Article
Multidisciplinary Sciences
Angelique M. L. Scantlebery, Peter Ochodnicky, Lotte Kors, Elena Rampanelli, Loes M. Butter, Chaima El Boumashouli, Nike Claessen, Gwen J. Teske, Marius A. van den Bergh Weerman, Jaklien C. Leemans, Joris J. T. H. Roelofs, Sandrine Florquin
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Onno J. de Boer, Gabrielle Krebbers, Claire Mackaaij, Sandrine Florquin, Menno A. de Rie, Allard C. van der Wal, Marcel B. M. Teunissen
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Letter
Cell Biology
Onno J. de Boer, Gabrielle Krebbers, Claire Mackaaij, Sandrine Florquin, Menno A. de Rie, Allard C. van der Wal, Marcel B. M. Teunissen
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)