Article
Cell Biology
Rebecca Herzog, Juan Manuel Sacnun, Guadalupe Gonzalez-Mateo, Maria Bartosova, Katarzyna Bialas, Anja Wagner, Markus Unterwurzacher, Isabel J. Sobieszek, Lisa Daniel-Fischer, Krisztina Rusai, Lucia Pascual-Anton, Klaus Kaczirek, Andreas Vychytil, Claus Peter Schmitt, Manuel Lopez-Cabrera, Seth L. Alper, Christoph Aufricht, Klaus Kratochwill
Summary: Adding lithium chloride to peritoneal dialysis fluid can improve mesothelial cell survival, reduce angiogenesis and fibrosis, and provide a translatable intervention to counteract peritoneal membrane deterioration during PD therapy. This study identified a potential therapeutic strategy in repurposing LiCl as a cytoprotective PDF additive to combat PD-induced mesothelial cytotoxicity.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Junxia Feng, Meizhi Lu, Wenhao Li, Jingchun Li, Ping Meng, Zukai Li, Xuejuan Gao, Yunfang Zhang
Summary: This study found that PPAR gamma can inhibit the progression of high glucose-induced peritoneal fibrosis by increasing GLUT1 expression and suppressing peritoneal mesothelial cell proliferation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Piccapane, Mario Bonomini, Giuseppe Castellano, Andrea Gerbino, Monica Carmosino, Maria Svelto, Arduino Arduini, Giuseppe Procino
Summary: The novel formulation of dialytic solutions, replacing a substantial amount of glucose with xylitol and l-carnitine, shows better performance in terms of higher cell viability, better preservation of the integrity of the mesothelial layer, and reduced release of pro-inflammatory cytokines. This new formulation could represent a step forward towards obtaining PD solutions with high biocompatibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Alexandra Helmke, Anne M. Huesing, Svenja Gaedcke, Nicolas Brauns, Michael S. Balzer, Martin Reinhardt, Marcus Hiss, Nelli Shushakova, David de Luca, Immo Prinz, Hermann Haller, Sibylle von Vietinghoff
Summary: This study demonstrates that hypertonic glucose used in peritoneal dialysis can induce Th17 polarization in T cells, with a dose-dependent effect on IL-17A production. The mechanism involves modulation of mitochondrial function and reactive oxygen species (ROS). Understanding and modulating the effects of glucose in PD solutions may help improve membrane survival in patients undergoing peritoneal dialysis.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wenyan Su, Zuoyu Hu, Xiaohong Zhong, Ansheng Cong, Ying Zhang, Zhanmei Zhou, Jianyi Li, Cailing Su, Yujie Huang, Wei Cao
Summary: This study found that the fibrosis in peritoneal dialysis patients is associated with decreased fatty acid oxidation and carnitine palmitoyltransferase 1A expression. Overexpression of carnitine palmitoyltransferase 1A can reverse the fibrosis process.
Article
Biochemistry & Molecular Biology
Chi-Chong Tang, Jen-Pi Tsai, Yi-Hsin Chen, Szu-Chun Hung, Yu-Li Lin, Bang-Gee Hsu
Summary: Disruptions in glucose metabolism are common among peritoneal dialysis (PD) patients, and impaired fasting glucose, insulin resistance, and PD glucose load are closely associated with aortic stiffness in PD patients without diabetes mellitus (DM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Qiang Huang, Yuxiang Sun, Long Peng, Juan Sun, Zixin Sha, Hongchun Lin, Yongjie Li, Canming Li, Huiqun Li, Hongli Shang, Yanxu Chen, Xianrui Dou, Zhaoyong Hu, Zengchun Ye, Hui Peng
Summary: Progressive peritoneal fibrosis and peritoneal dysfunction in patients undergoing long-term peritoneal dialysis are mediated by extracellular vesicles (EVs) released by mesothelial cells. Transforming growth factor-beta 1 (TGF-β1) can stimulate the release of EVs from mesothelial cells, which in turn activate fibroblasts and promote peritoneal fibrogenesis. Inhibiting EVs secretion or blocking the integrin-linked kinase (ILK) pathway can suppress fibroblast activation and peritoneal fibrosis. Clinical analysis showed that increased expression of ILK in fibrotic peritoneum correlated with peritoneal dysfunction and damage. This study suggests that targeting EVs or ILK could be a potential therapeutic strategy for peritoneal fibrosis.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Biochemistry & Molecular Biology
Ruipeng Wang, Tiankang Guo, Junliang Li
Summary: Peritoneal adhesion (PA) is a fibrotic tissue that connects abdominal or visceral organs to the peritoneum, and its formation can lead to various clinical diseases. Damage to peritoneal mesothelial cells (PMCs) is believed to be one of the causes of PA. This review aims to understand the mechanism of action of PMCs in PA and provide a theoretical foundation for the treatment and prevention of PA.
Article
Pharmacology & Pharmacy
Shunyun Xie, Feng Xu, Yue Lu, Yixian Zhang, Xinyang Li, Mengyuan Yu, Wenpeng Cui
Summary: Peritoneal fibrosis is a common complication in patients receiving peritoneal dialysis, and effective treatment is currently unavailable. ELA and APLN have potential therapeutic effects on PD-related fibrosis. ELA-32 can interfere with the EMT of HPMCs by inhibiting the activation of the TGF-beta 1/SMAD2/3, ERK1/2, and AKT pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olalla Ramil-Gomez, Mirian Lopez-Pardo, Jennifer Adriana Fernandez-Rodriguez, Ana Rodriguez-Carmona, Teresa Perez-Lopez, Carlos Vaamonde-Garcia, Miguel Perez-Fontan, Maria Jose Lopez-Armada
Summary: Recent studies have shown that IL-1 beta can cause mitochondrial damage in mesothelial cells, leading to an increased sensitivity to cytokines and amplified inflammatory response. Resveratrol attenuates the inflammatory response by regulating mitochondrial function and reversing the decline in mitochondrial membrane potential caused by IL-1 beta.
Article
Medicine, General & Internal
Kazuma Kobayashi, Toshikazu Ozeki, Hangsoo Kim, Masaki Imai, Hiroshi Kojima, Daiki Iguchi, Sosuke Fukui, Masafumi Suzuki, Yasuhiro Suzuki, Shoichi Maruyama, Yasuhiko Ito, Masashi Mizuno
Summary: This study found that membrane complement regulators are highly expressed on human peritoneal mesothelial cells, and the history of peritoneal dialysis might influence their expression. These findings suggest that mesothelial cells may alter the expression of complement regulators to protect the peritoneum, and the presence of peritoneal dialysis fluid may affect the homeostasis associated with the complement system.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Tara E. Sutherland, Tovah N. Shaw, Rachel Lennon, Sarah E. Herrick, Dominik Rueckerl
Summary: Peritoneal dialysis initially benefits patients with chronic kidney disease, but long-term use may lead to significant pathology, increasing the risk of infection and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunmee Lho, Jun-Young Do, Jung-Yoon Heo, A-Young Kim, Sang-Woon Kim, Seok-Hui Kang
Summary: The TGF-beta receptor inhibitor GW788388 effectively attenuated TGF-beta-induced EMT in HPMCs and improved peritoneal thickness and fibrosis in a peritoneal fibrosis mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Anna Mary Steitz, Clarissa Schroeder, Isabel Knuth, Corinna U. Keber, Leah Sommerfeld, Florian Finkernagel, Julia M. Jansen, Uwe Wagner, Sabine Muller-Bruesselbach, Thomas Worzfeld, Magdalena Huber, Vanessa M. Beutgen, Johannes Graumann, Elke Pogge von Strandmann, Rolf Mueller, Silke Reinartz
Summary: In ovarian high-grade serous carcinoma (HGSC), disruption of the protective peritoneal mesothelium is a crucial requirement for metastasis formation. This study discovered that tumor-associated NK cells induce TRAIL-dependent apoptosis in mesothelial cells via death receptors DR4 and DR5 when encountering activated T cells. The upregulation of TRAIL expression in NK cells and enhanced cytotoxicity towards mesothelial cells are primarily driven by T-cell-derived TNFa. Apoptotic mesothelial cells were found in the peritoneal fluid of HGSC patients, indicating a cooperative action of T and NK cells in breaching the mesothelial barrier.
Article
Biochemistry & Molecular Biology
Chia-Ning Chang, Chih-Yuan Niu, Ann Charis Tan, Chia-Hao Chan, Chun-Fan Chen, Tz-Heng Chen, Szu-Yuan Li, Yung-Tai Chen, Fan-Yu Chen, Wen-Sheng Li, Chih-Ching Lin, Guor-Jien Wei
Summary: This study investigated the impact of FIR therapy on dialysate GDPs and peritoneal function in diabetic patients on PD. The results showed that FIR therapy decreased GDPs in PD solutions, improved glucose transport rate, and maintained or increased peritoneal adequacy in both diabetic and non-diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Gastroenterology & Hepatology
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Ken Ishimura, Kunihisa Uchita, Akira Nishiyama, Tsutomu Masaki
Review
Peripheral Vascular Disease
Ningning Wan, Asadur Rahman, Akira Nishiyama
Summary: Esaxerenone, a novel nonsteroidal mineralocorticoid receptor blocker, has shown efficacy and good tolerability in treating hypertensive patients in Japan. In addition to lowering blood pressure, esaxerenone also demonstrates renoprotective effects. Clinical trials have indicated the potential clinical application of esaxerenone in treating renal diseases.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Article
Surgery
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tadayuki Takata, Kazuhiro Kozuka, Takanori Matsui, Nobuya Kobayashi, Taiga Chiyo, Koji Fujita, Joji Tani, Tatsuo Yachida, Akihito Tsuji, Keiichi Okano, Yasuyuki Suzuki, Daisuke Nakano, Akira Nishiyama, Tsutomu Masaki
Summary: This study concludes that the guidewire-assisted OTSC delivery (GOD) method is a feasible and safe technique for delivering OTSC to the small and proximal large intestine.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Urology & Nephrology
Adriana Marton, Tatsuroh Kaneko, Jean-Paul Kovalik, Atsutaka Yasui, Akira Nishiyama, Kento Kitada, Jens Titze
Summary: SGLT2 inhibitors induce metabolic adaptations similar to aestivation, helping patients adapt to reduced energy availability and conserve water. These metabolic adjustments may contribute to the favorable cardiovascular and renal outcomes of SGLT2 inhibitor therapy.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Peripheral Vascular Disease
Satoshi Kidoguchi, Naoki Sugano, Gorou Tokudome, Takashi Yokoo, Yuichiro Yano, Kiyohiko Hatake, Akira Nishiyama
Summary: Due to aging populations, the prevalence of hypertension, cardiovascular events, and cancer is increasing globally. Small-molecule inhibitors used in cancer therapy have a positive impact on prognosis and survival of cancer patients, leading to a rapid increase in cancer survivors with hypertension. However, there is a lack of evidence on optimal blood pressure control for cancer patients with hypertension, highlighting the need for further research on the concept of onco-hypertension.
Article
Surgery
Nobuya Kobayashi, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Kazuhiro Kozuka, Naoya Tada, Takanori Matsui, Taiga Chiyo, Tadayuki Takata, Koji Fujita, Joji Tani, Tatsuo Yachida, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: The study demonstrated that the WaRP method has a high technical success rate and safety in reducing post-ESD bleeding after gastric ESD, making it a simple and reliable approach.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Surgery
Yasuhiro Goda, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Tingting Shi, Koji Fujita, Joji Tani, Tatsuo Yachida, Masashi Takata, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: This study examined the clinical outcomes and long-term characteristics of patients treated with Over-The-Scope Clip (OTSC). The results showed a 100% clinical success rate and a 2.9% complication rate during the observation period. OTSC remains effective in the long-term.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Physiology
Johannes Kovarik, Norihiko Morisawa, Johannes Wild, Adriana Marton, Kaoru Takase-Minegishi, Shintaro Minegishi, Steffen Daub, Jeff M. Sands, Janet D. Klein, James L. Bailey, Jean-Paul Kovalik, Manfred Rauh, Susanne Karbach, Karl F. Hilgers, Friedrich Luft, Akira Nishiyama, Daisuke Nakano, Kento Kitada, Jens Titze
Summary: Our study found that rats with 5/6 nephrectomy showed polyuria due to the inability of their kidneys to concentrate urine, but they were able to adapt physiologically by mobilizing nitrogen and energy from muscle, increasing norepinephrine and copeptin levels, and reducing skin blood flow to compensate for transepidermal water loss. This complex physiologic-metabolic adjustment across multiple organs allowed the rats to stabilize their body water content despite persisting renal water loss, although it led to hypertension and muscle catabolism.
Article
Surgery
Yohei Doi, Makoto Tsujita, Takayuki Hamano, Yoshitsugu Obi, Tomoko Namba-Hamano, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Norihiko Goto, Akira Nishiyama, Asami Takeda, Shunji Narumi, Yoshihiko Watarai, Yoshitaka Isaka
Summary: Cholecalciferol supplementation did not significantly improve allograft outcomes in kidney transplant recipients, with no significant impact on eGFR change compared to placebo. However, it showed detrimental effects in patients with eGFR <45 mL/min/1.73 m(2).
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Hematology
Eri Muso, Soichi Sakai, Youske Ogura, Susumu Yukawa, Yoshiki Nishizawa, Noriaki Yorioka, Takao Saito, Masatoshi Mune, Satoshi Sugiyama, Yasuhiko Iino, Tsutomu Hirano, Motoshi Hattori, Tsuyoshi Watanabe, Hitoshi Yokoyama, Hiroshi Sato, Shunya Uchida, Takashi Wada, Tetsuo Shoji, Hiroaki Oda, Kiyoshi Mori, Hideki Kimura, Osamu Ito, Akira Nishiyama, Shoichi Maruyama, Reiko Inagi, Shoichi Fujimoto, Tatsuo Tsukamoto, Yusuke Suzuki, Hirokazu Honda, Tetsuya Babazono, Kazuhiko Tsuruya, Yukio Yuzawa
Summary: Many reports have demonstrated the therapeutic efficacy of LDL-Apheresis in improving heavy proteinuria and severely impaired renal function in cases of drug-resistant nephrotic syndrome. A post hoc analysis of the POLARIS study showed significant improvements in proteinuria and renal function in cases with normal and moderately impaired renal function, and a trend for improvement in severely impaired renal function. Most cases did not progress to end-stage renal disease within 2 years after LDL-A treatment.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Health Care Sciences & Services
Tadashi Sofue, Taiga Hara, Yoko Nishijima, Satoshi Nishioka, Hiroyuki Watatani, Masahito Yamanaka, Norihiro Takahashi, Akira Nishiyama, Tetsuo Minamino
Summary: After the implementation of the NHI special health checkup and chronic kidney disease (CKD) initiative in Kagawa prefecture, there was an increase in the prevalence of CKD and the coverage rate of NHI health checkups.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mai Hattori, Asadur Rahman, Satoshi Kidoguchi, Nourin Jahan, Yoshihide Fujisawa, Norihiko Morisawa, Hiroyuki Ohsaki, Hideki Kobara, Tsutomu Masaki, Akram Hossain, Akumwami Steeve, Akira Nishiyama
Summary: This study investigated the effects of the nonsteroidal mineralocorticoid receptor blocker esaxerenone on blood pressure and renal health in salt-loaded conditions. The results showed that esaxerenone significantly reduced blood pressure and attenuated renal damage induced by high salt intake. These effects were associated with the modulation of sodium homeostasis by esaxerenone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Godoy-Lugo, Max A. Thorwald, Dora A. Mendez, Ruben Rodriguez, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz
Summary: This study found that long-term AT1 blockade can increase nuclear Nrf2 content and reduce the expression of antioxidant enzymes, thereby promoting the development of NAFLD. The angiotensin receptor blocker can alleviate the impact of hyperglycemia on Nrf2, suggesting its role in antioxidant defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Asadur Rahman, Nourin Jahan, Md Tanvir Rahman, Akira Nishiyama
Summary: Inappropriate mineralocorticoid receptor (MR) activation in cardiovascular cells has negative effects on cardiac remodeling and function. MR inhibition is an important strategy to overcome cardiovascular dysfunction, but the clinical application of steroidal MR antagonists is limited due to adverse effects. Newer non-steroidal MR antagonists show promise for clinical use, particularly in patients with type 2 diabetes and chronic kidney disease. Pre-clinical and clinical evidence supports the use of non-steroidal MR antagonists in treating cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Rudy M. Ortiz, Ryousuke Satou, Jia L. Zhuo, Akira Nishiyama
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)