Review
Food Science & Technology
Monica R. Meza-Meza, Adolfo I. Ruiz-Ballesteros, Ulises de la Cruz-mosso
Summary: Vitamin D can be obtained from various sources and plays a critical role in immune regulation through both genomic and non-genomic mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Basma A. Abdelrahman, Olfat A. Hammam, Aiman S. El-Khatib, Yasmeen M. Attia
Summary: The active form of vitamin D3, calcitriol (CAL), can ameliorate non-alcoholic steatohepatitis (NASH) by inhibiting NLRP3 inflammasome activation in an autophagy-dependent manner. CAL also induces autophagy, further enhancing its therapeutic effect on NASH.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Junjie Hu, Jiawei Wu, Fang Wan, Liang Kou, Sijia Yin, Yadi Sun, Yunna Li, Qiulu Zhou, Tao Wang
Summary: This study investigated the role of vitamin D in Parkinson's disease models, finding that calcitriol can improve cell death and neuronal damage in PD models, potentially through modulation of the VDR/PARP1 pathway. The results suggest a new possibility for the treatment of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Oncology
Katia Danza, Letizia Porcelli, Simona De Summa, Roberta Di Fonte, Brunella Pilato, Rosanna Lacalamita, Simona Serrati, Amalia Azzariti, Stefania Tommasi
Summary: ERRα plays a role in the proliferation of breast cancer cell lines and as a regulator of the VDR pathway, affecting cell cycle arrest and regulating gene expression. In breast cancer, overexpression of VDR, CYP24A1, and ERRα is associated with poor prognosis.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shachi Pranjal Vyas, Ritobrata Goswami
Summary: Vitamins play a crucial role in regulating the differentiation of T helper cells, with calcitriol and retinoic acid exhibiting hormone-like properties and antagonizing each other in this process. The recruitment of PU.1 to the Il9 gene is significantly impaired in the presence of either vitamin alone, but their combined treatment increases the recruitment. Interestingly, retinoic acid dampens the binding of VDR on the Il9 gene, negating the effect of calcitriol.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Junjie Hu, Jiawei Wu, Fang Wan, Liang Kou, Sijia Yin, Yadi Sun, Yunna Li, Qiulu Zhou, Tao Wang
Summary: Recent studies have suggested a correlation between vitamin D and Parkinson's disease, with calcitriol showing potential to improve PD models and inhibit the parthanatos pathway. Experimental validation indicates that the protective effect of calcitriol in PD may be partly mediated through the VDR/PARP1 pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Manjunath Havalappa Dodamani, Anurag Ranjan Lila, Saba Samad Memon, Vijaya Sarathi, Sneha Arya, Ankita Rane, Manjeet Kaur Sehemby, Robin Garg, Vishwambhar Vishnu Bhandare, Manjiri Karlekar, Virendra A. Patil, Ambarish Kunwar, Tushar R. Bandgar
Summary: Alopecia in hereditary vitamin D resistant rickets (HVDRR) is associated with severe rickets and poor overall response. Genetic analysis revealed four novel variants and showed a correlation between alopecia and specific genotypes. Overall response to therapy varied depending on the genotype.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Fang Yuan, Ning Wang, Yan Chen, Xinping Huang, Zhen Yang, Yingying Xu, Kai You, Jiaye Zhang, Guodong Wang, Yuanqi Zhuang, Tingcai Pan, Yue Xiong, Xiaorui Yu, Fan Yang, Yinxiong Li
Summary: Adding activated vitamin D (VD) in human pluripotent stem cells (hPSCs)-derived hepatocyte-like cells (HLCs) can enhance their liver function and mitochondrial condition, and this improvement is dependent on vitamin D receptor (VDR).
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Oncology
Nancy Santos-Martinez, Lorenza Diaz, Victor M. Ortiz-Ortega, David Ordaz-Rosado, Heriberto Prado-Garcia, Euclides Avila, Fernando Larrea, Rocio Garcia-Becerra
Summary: Calcitriol induces ER alpha expression in ER-negative breast cancer cells through binding of the VDR-RXR complex to VDREs in the ER alpha gene promoter region, including downregulation of chromatin-remodeling enzymes. Co-treatment of calcitriol with inhibitors of histone deacetylase and DNA methyltransferase significantly increases ER alpha expression, providing new mechanistic insights into the actions of calcitriol in ER-negative breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Virology
Carmen Stecher, Katharina Philomena Maurer, Marie-Theres Kastner, Christoph Steininger
Summary: This study demonstrated that HCMV infection can lead to downregulation of the vitamin-D receptor, rendering vitamin D ineffective against the virus. Additionally, inhibiting histone deacetylase could restore VDR expression, while upregulation of the transcriptional repressor Snail1 was correlated with VDR downregulation.
Article
Genetics & Heredity
Monica R. Meza-Meza, Barbara Vizmanos, Melissa Rivera-Escoto, Adolfo Ruiz-Ballesteros, Karen Pesqueda-Cendejas, Isela Parra-Rojas, Margarita Montoya-Buelna, Sonia Luquin, Bertha Campos-Lopez, Paulina E. Mora-Garcia, Sergio Cerpa-Cruz, Ulises De la Cruz-Mosso
Summary: The study found that the TT FokI VDR genotype is associated with high VDR expression and clinical disease activity in systemic lupus erythematosus patients.
Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Article
Environmental Sciences
Ettayapuram Ramaprasad Azhagiya Singam, Kathleen A. Durkin, Michele A. La Merrill, J. David Furlow, Jen-Chywan Wang, Martyn T. Smith
Summary: Due to their persistence and toxicity, PFASs pose significant risks to human health and the environment. They have various effects, including immune suppression, hormone disruption, and osteoporosis. This study found that certain PFASs can strongly bind to the Vitamin D receptor (VDR), which plays a crucial role in maintaining immune, endocrine, and calcium homeostasis. Some commercially important PFASs and PFASs found in water supplies and human blood samples were identified as potent binders to VDR, potentially causing harmful effects on different body systems.
ENVIRONMENTAL RESEARCH
(2023)
Article
Otorhinolaryngology
David C. Shonka, Anne K. Maxwell, Gina R. Petroni, Mark J. Jameson
Summary: This study showed that preoperative calcitriol supplementation had no impact on postoperative serum calcium levels following total thyroidectomy. There were no significant differences between the two groups in terms of postoperative serum calcium levels, incidence of hypocalcemia, length of stay, and other outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Agriculture, Dairy & Animal Science
M. Meyer-Binzegger, C. Ollagnier, L. Eggerschwiler, K. Buhler, M. Meylan, P. Schlegel
Summary: Periparturient hypocalcaemia is a common metabolic disorder in dairy cows, but preventive treatment with 1,25-dihydroxyvitamin D-3 may help maintain normal blood calcium levels.
Article
Transplantation
Alberto Ortiz, Charles J. Ferro, Olga Balafa, Michel Burnier, Robert Ekart, Jean-Michel Halimi, Reinhold Kreutz, Patrick B. Mark, Alexandre Persu, Patrick Rossignol, Luis M. Ruilope, Roland E. Schmieder, Jose M. Valdivielso, Lucia Del Vecchio, Carmine Zoccali, Francesca Mallamaci, Pantelis Sarafidis
Summary: Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease (CKD), with high risks of kidney failure and cardiovascular death for patients with CKD, especially those with diabetes. Renin-angiotensin system (RAS) blockers and sodium-glucose co-transporter-2 inhibitors (SGLT2is) have shown some protective effects, but the risks remain high. Steroidal mineralocorticoid receptor antagonists (MRAs) may provide potential benefits, but safety concerns exist. The FInerenone in reducing kiDnEy faiLure and dIsease prOgression in DKD (FIDELIO-DKD) study has shown promising results for non-steroidal MRA finerenone.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Peripheral Vascular Disease
Maria del Mar Vila, Laura Igual, Beatriz Remeseiro, Roberto Elosua, Rafel Ramos, Jose M. Valdivielso, Ruth Marti-Lluch, Jaume Marrugat, Maria Grau
Summary: This study assessed the correlation between biomarkers of lower limb atherosclerosis and carotid atherosclerosis. The results showed a linear trend between ankle-brachial index and common carotid intima-media thickness in men, and women with peripheral artery disease had a higher risk of atherosclerotic plaque in the carotid artery.
Article
Cardiac & Cardiovascular Systems
Kunihiro Matsushita, Stephen Kaptoge, Steven H. J. Hageman, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J. Brunskill, Alex R. Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T. Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H. Jafar, Simerjot K. Jassal, Takamasa Kayama, Csaba P. Kovesdy, Gijs W. Landman, Andrew S. Levey, Donald M. Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N. Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J. Pena, Kevan R. Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P. Schneider, Varda Shalev, Michael G. Shlipak, Marit D. Solbu, Nikita Stempniewicz, James Tollitt, Jose M. Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick A. N. Dorresteijn, Emanuele Di Angelantonio, Frank L. J. Visseren, Lisa Pennells, Josef Coresh
Summary: This study developed an "Add-on" method to incorporate chronic kidney disease (CKD) measures into cardiovascular disease (CVD) risk prediction algorithms, which improved the predictive accuracy. This approach will assist clinicians and patients in more precise risk assessment and personalized preventive therapies for CKD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marcelino Bermudez-Lopez, Manuel Marti-Antonio, Eva Castro-Boque, Maria del Mar Bretones, Cristina Farras, Jessica Gonzalez, Reinald Pamplona, Albert Lecube, Didac Mauricio, Serafi Cambray, Jose Manuel Valdivielso, Elvira Fernandez
Summary: Cumulative tobacco consumption (CTC) has a sex-specific impact on atheromatosis extension and total plaque area. This study found that CTC was associated with an increased risk of atheromatosis, particularly in femoral arteries. The addition of CTC to the SCORE2 model improved the prediction of severe atheromatosis, especially in males.
Review
Biochemistry & Molecular Biology
Beatriz Martin-Carro, Javier Donate-Correa, Sara Fernandez-Villabrille, Julia Martin-Virgala, Sara Panizo, Natalia Carrillo-Lopez, Laura Martinez-Arias, Juan F. F. Navarro-Gonzalez, Manuel Naves-Diaz, Jose L. Fernandez-Martin, Cristina Alonso-Montes, Jorge B. Cannata-Andia
Summary: Preclinical biomedical models play a fundamental role in advancing our understanding and management of diseases, particularly diabetes mellitus. This is because the pathophysiological and molecular mechanisms underlying diabetes development are not fully understood, and there is currently no cure for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Transplantation
Patrick B. Mark, Pantelis Sarafidis, Robert Ekart, Charles J. Ferro, Olga Balafa, Beatriz Fernandez-Fernandez, William G. Herrington, Patrick Rossignol, Lucia Del Vecchio, Jose M. Valdivielso, Francesca Mallamaci, Alberto Ortiz, Ionut Nistor, Mario Cozzolino
Summary: Chronic kidney disease (CKD) affects an estimated 850 million people worldwide and the leading causes are diabetes and hypertension. CKD can progress to end-stage kidney disease, requiring kidney replacement therapy. In addition, CKD is a risk factor for cardiovascular disease. Previously, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) were the mainstay of treatment, but they did not reduce cardiovascular events and mortality in CKD. However, sodium-glucose cotransporter-2 inhibitors (SGLT2i) have shown cardiovascular and renal benefits in clinical trials, revolutionizing cardiorenal protection for patients with diabetes. Recent trials have demonstrated the benefits of SGLT2i in reducing heart failure and progression to kidney failure in patients with CKD and/or heart failure. Specialty societies' guidelines are adapting to support wider use of SGLT2i. The consensus paper from EURECA-m and ERBP summarizes the latest evidence and guidelines for using SGLT2i for cardiorenal protection in CKD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Laura Martinez-Arias, Sara Fernandez-Villabrille, Cristina Alonso-Montes, Gonzalo Garcia-Navazo, Maria P. Ruiz-Torres, Ramon Alajarin, Julio Alvarez-Builla, Elena Gutierrez-Calabres, Juan Jose Vaquero-Lopez, Natalia Carrillo-Lopez, Diego Rodriguez-Puyol, Jorge B. Cannata-Andia, Sara Panizo, Manuel Naves-Diaz
Summary: This study examined the effects of GGN1231, a hybrid compound derived from losartan, in a rat model of chronic renal failure. The results showed that GGN1231 reduced cardiovascular damage and fibrosis, suggesting its potential in managing cardiovascular and inflammatory processes.
Article
Hematology
Maite Caus, Cristina Alonso-Montes, Jose Luis Fernandez-Martin, Manuel Marti-Antonio, Milica Bozic, Jose M. Valdivielso
Summary: This study investigated the role of local vitamin D signaling in vascular smooth muscle cells (VSMCs) during chronic kidney disease (CKD)-induced vascular calcification (VC). The results showed that CKD-affected patients and mice with CKD exhibited increased VC and arterial expression of vitamin D receptor (VDR). Conditional gene silencing of VDR in VSMCs led to a significant decrease in VC in the mouse model of CKD. In addition, miR-145a was found to be involved in VC, and its expression was recovered in animals with deletion of VDR in VSMCs.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Idalia Rojo-Lopez, Marcelino Bermudez-Lopez, Eva Castro, Cristina Farras, Gerard Torres, Reinald Pamplona, Albert Lecube, Jose Manuel Valdivielso, Elvira Fernandez, Josep Julve, Esmeralda Castelblanco, Josep Franch-Nadal, Nuria Alonso, Minerva Granado-Casas, Didac Mauricio
Summary: The aim of this study was to evaluate the association between the Mediterranean diet and subclinical atherosclerotic disease. The results showed that higher adherence to the Mediterranean diet was associated with a lower risk of atherosclerotic plaques, and moderate or high adherence to the diet was associated with a lower number of plaques.
Article
Medicine, Research & Experimental
Nuria Dolade, Sandra Rayego-Mateos, Alicia Garcia-Carrasco, Maryse Guerin, Jose-Luis Martin-Ventura, Marta Ruiz-Ortega, Pierre -Louis Tharaux, Jose Manuel Valdivielso
Summary: In chronic kidney disease (CKD), atherosclerotic cardiovascular disease is accelerated, but the specific CKD-related risk factors for atherosclerosis are unknown. This study found that down-regulation of BTLA may be associated with the incidence and progression of atherosclerosis in CKD patients.
Article
Transplantation
Pedro Barrera-Baena, Minerva Rodriguez-Garcia, Enrique Rodriguez-Rubio, Lucia Gonzalez-Llorente, Alberto Ortiz, Carmine Zoccali, Francesco Locatelli, Juergen Floege, Martine Cohen-Solal, Manuel Anibal Ferreira, Markus Ketteler, Gerard Michel London, Jose Luis Gorriz-Teruel, Emilio Sanchez-Alvarez, Miguel Angel Hevia-Suarez, Jesus Maria Fernandez-Gomez, Beatriz Martin-Carro, Carlos Gomez-Alonso, Cristina Alonso-Montes, Jorge Benito Cannata-Andia, Jose Luis Fernandez-Martin
Summary: This study analyzed the association between biochemical parameters of CKD-MBD and bone fragility fractures in hemodialysis patients, and found that hyperphosphatemia is independently and consistently associated with an increased risk of bone fractures.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Sara Fernandez-Villabrille, Beatriz Martin-Carro, Julia Martin-Virgala, Cristina Alonso-Montes, Alejandra Fernandez-Fernandez, Carlos Martinez-Salgado, Jose L. Fernandez-Martin, Manuel Naves-Diaz, Jorge B. Cannata-Andia, Natalia Carrillo-Lopez, Sara Panizo
Summary: The objective of this study was to investigate the effect of high phosphorus exposure on the levels of miR-145 and its effect on vascular smooth muscle cell changes. Results showed that high phosphorus exposure reduced miR-145 levels and led to decreased expression of a-actin. These findings suggest that miR-145 could serve as an early biomarker of vascular calcification.
Article
Urology & Nephrology
Jose M. Valdivielso, Sol Carriazo, Marisa Martin, Beatriz Fernandez-Fernandez, Marcelino Bermudez-Lopez, Alberto Ortiz, Aladren Regidor, Jaume Almirall, Esther Ponz, Arteaga Coloma, Bajo Rubio, Diaz M Auxiliadora, Montserrat Belart Rodriguez, Antonio Gascon, Jordi Bover Sanjuan, Josep Bronsoms Artero, Juan B. Cabezuelo Romero, Salome Muray Cases, Jesus Calvino Varela, Pilar Caro Acevedo, Jordi Carreras Bassa, Aleix Cases Amenos, Elisabet Masso Jimenez, Rosario Moreno Lopez, Secundino Cigarran Guldris, Saray Lopez Prieto, Lourdes Comas Mongay, Isabel Comerma, M. Teresa Compte Jove, Marta Cuberes Izquierdo, Fernando de alvaro, Covadonga Hevia Ojanguren, Gabriel de Arriba de la Fuente, M. Dolores Pino, Rafael Diaz-Tejeiro Izquierdo, Marta Dotori, Veronica Duarte, Sara Estupinan Torres, M. Jose Fernandez Reyes, M. Loreto Fernandez Rodriguez, Guillermina Fernandez, Antonio Galan Serrano, Cesar Garcia Canton, Antonio L. Garcia Herrera, Mercedes Garcia Mena, Luis Gil Sacaluga, Maria Aguilar, Jose Luis Gorriz, Emma Huarte Loza, Jose Luis Lerma, Antonio Liebana Canada, Jesus Pedro Marin alvarez, Nadia Martin Alemany, Jesus Martin Garcia, Alberto Martinez Castelao, Maria Martinez Villaescusa, Isabel Martinez, Inigo Moina Eguren, Silvia Moreno Los Huertos, Ricardo Mouzo Mirco, Antonia Munar Vila, Ana Beatriz Munoz Diaz, Juan F. Navarro Gonzalez, Javier Nieto, Agustin Carreno, Enrique Novoa Fernandez, Alberto Ortiz, Beatriz Fernandez, Vicente Paraiso, Miguel Perez Fontan, Ana Peris Domingo, Celestino Pinera Haces, M. Dolores Prados Garrido, Mario Prieto Velasco, Carmina Puig Mari, Maite Rivera Gorrin, Esther Rubio, Pilar Ruiz, Mercedes Salgueira Lazo, Ana Isabel Martinez Puerto, Jose Antonio Sanchez Tomero, Jose Emilio Sanchez, Ramon Sans Lorman, Ramon Saracho, Maria Sarrias, Daniel Seron, Maria Jose Soler, Clara Barrios, Fernando Sousa, Daniel Toran, Fernando Tornero Molina, Jose Javier Uson Carrasco, Ildefonso Valera Cortes, M. Merce Vilaprinyo del Perugia, Rafael C. Virto Ruiz
Summary: Hyperkalemia is common among patients with chronic kidney disease, but differential risk factors and outcomes exist between men and women. Smoking is identified as a risk factor for hyperkalemia in men, while hyperkalemia is associated with an increased risk of cardiovascular events in men. Additionally, women are more likely to stop using RAASi.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Serafi Cambray, Marcelino Bermudez-Lopez, Alicia Garcia-Carrasco, Jose M. Valdivielso, NEFRONA investigators
Summary: This study investigated the role of single nucleotide polymorphisms (SNPs) of the matrix gamma-carboxy glutamic acid protein (MGP) gene on atherosclerosis progression and cardiovascular events (CVE) in CKD patients. The results showed that the rs1800802 polymorphism of MGP is associated with increased risk of plaque progression and CVE in CKD patients.
CLINICAL KIDNEY JOURNAL
(2023)
