Review
Medicine, General & Internal
Daisuke Tamura, Shintaro Narita, Misa Yamauchi, Rina Watanabe, Shota Yokoyama, Akane Kikuchi, Akihiro Shitara, Syuji Chiba, Fumiko Saito, Akihiro Sugita, Kazunari Sato, Akihiro Karube
Summary: This article reports a case of giant hydronephrosis associated with ureteropelvic junction obstruction detected during pregnancy, which was treated conservatively and underwent surgical treatment after delivery, and provides a literature review on the related topics.
Article
Medicine, General & Internal
Pierluigi Marzuillo, Pier Luigi Palma, Anna Di Sessa, Agnese Roberti, Giovanni Torino, Maeva De Lucia, Emanuele Miraglia del Giudice, Stefano Guarino, Giovanni Di Iorio
Summary: The aim of this study was to determine whether early measurements of serum aldosterone levels or plasmatic renin activity (PRA) could predict the need for surgical intervention in infants with obstructive congenital anomalies of kidney and urinary tract (CAKUT). A total of 20 infants aged 1-3 months with suspected obstructive CAKUT were prospectively enrolled and followed up for 2 years. The results showed that infants who required surgery had significantly higher levels of aldosterone at 1-3 months compared to those who did not require surgery (p = 0.006). The ROC curve analysis identified a cut-off of 100 ng/dL for aldosterone, which predicted the need for surgery with 100% sensitivity and 64.3% specificity. However, PRA measured at 1-3 months was not a predictor of surgery. In conclusion, early measurements of serum aldosterone levels can serve as a predictor for surgical intervention in infants with obstructive CAKUT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Martina Frech-Doerfler, Sabrina Durand, Friederike Pruefer, Stefan Holland-Cunz, Christoph Rudin
Summary: This case report describes a baby boy with prenatal bilateral giant hydronephrosis, highlighting the successful treatment and restoration of kidney function through emergency interventions.
Article
Cell Biology
Lihong Tan, Minghui Yu, Yaxin Li, Shanshan Xue, Jing Chen, Yihui Zhai, Xiaoyan Fang, Jialu Liu, Jiaojiao Liu, Xiaohui Wu, Hong Xu, Qian Shen
Summary: Congenital anomalies of the kidney and urinary tract (CAKUT) is a common birth defect caused by complex genetic and environmental factors. Recent studies have suggested the involvement of long non-coding RNAs in the development of the kidney and urinary tract system. Research using PB transposon-based mutagenesis found that abnormal expression of Rik may lead to a reduction in UB branches by downregulating Bmp4, contributing to the development of CAKUT.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Giulio Rivetti, Pietro Gizzone, Anna Di Sessa, Stefano Guarino, Emanuele Miraglia Del Giudice, Pierluigi Marzuillo
Summary: This review evaluates the efficacy of RAASi in treating proteinuria and CKD in children with CAKUT. While RAASi has shown effectiveness in reducing proteinuria and slowing CKD progression in many renal conditions, its efficacy in CAKUT patients is still uncertain. Therefore, a trial period of 6-12 months with gradual increase of RAASi dosage should be considered for CAKUT children with isolated proteinuria or proteinuria and CKD, and discontinuation of RAASi should be considered if no improvement in proteinuria is seen.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nela Kelam, Anita Racetin, Mirjana Polovic, Benjamin Benzon, Marin Ogorevc, Katarina Vukojevic, Merica Glavina Durdov, Ana Dunatov Huljev, Ivana Kuzmic Prusac, Davor Caric, Fila Raguz, Sandra Kostic
Summary: This study investigates the expression patterns of candidate genes for kidney and urinary tract congenital anomalies in human fetal kidney development. The results reveal significant variations in the expression patterns of these genes, suggesting their involvement in CAKUT pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pediatrics
Vijaya M. Vemulakonda
Summary: Ureteropelvic junction obstruction (UPJO) is a common cause of prenatal diagnosed hydronephrosis, with recent studies focusing on the use of ultrasound classification systems and MRI to stratify the risk in infants. Urinary biomarkers have also shown potential as a noninvasive alternative in identifying infants with clinically significant UPJO. Further research is needed to establish clear guidelines for evaluation and treatment to improve long-term outcomes for these patients.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Urology & Nephrology
Ronit Calderon-Margalit, Gil Efron, Oren Pleniceanu, Dorit Tzur, Michal Stern-Zimmer, Arnon Afek, Tomer Erlich, Estela Derazne, Jeremy D. Kark, Lital Keinan-Boker, Gilad Twig, Asaf Vivante
Summary: The study revealed that individuals with congenital anomalies of the kidney and urinary tract (CAKUT) had a significantly increased risk of developing urinary tract (UT) cancer in adulthood, particularly before 45 years of age for women and after 45 years of age for men. Despite the increased risk, the incidence and absolute risk of UT cancer remained relatively low.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Pediatrics
Jiandong Lu, Xiaozhu Liu, Yi Wei, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Guanghui Wei, Shengde Wu
Summary: This study investigated the clinical features and microbial etiology of urinary tract infection (UTI) in children. It found that Escherichia coli was the most common causative microorganism of UTI. Furthermore, children with urological malformations were more likely to develop UTI with atypical microorganisms and required longer treatment, higher treatment costs, and had a higher prevalence of recurrence.
FRONTIERS IN PEDIATRICS
(2022)
Article
Infectious Diseases
Kaiping Zhang, Yin Zhang, Min Chao, Zongyao Hao
Summary: The study aimed to detect the distribution of pathogenic bacteria and their antibiotic susceptibility among children with congenital anomalies of the kidney and urinary tract (CAKUT). A total of 568 children were included in the retrospective analysis. The most prevalent uropathogens were Escherichia coli, followed by Enterococcus faecalis and Enterococcus faecium. These uropathogens showed high resistance to commonly used antibiotics, and multiple drug resistance (MDR) was commonly observed.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, Research & Experimental
Mohamed Essam, Nashwa Barakat, Ahmed Elkashef, Amira Awadalla, A. E. Behery, Mahmoud Abdel-Maboud
Summary: The study showed that aliskiren significantly improved renal function, reduced necrosis and inflammatory cell infiltration in the cortex and medulla during acute and chronic partial ureteral obstruction in rat solitary kidney. Aliskiren also upregulated BCL-2 and downregulated IL-6, TGF-beta 1, collagen I, and fibronectin gene expression, while increasing GSH and SOD activity and reducing MDA and NO activity, leading to a more renoprotective effect when administered for four weeks compared to two weeks.
Article
Genetics & Heredity
Jeremiah Martino, Qingxue Liu, Katarina Vukojevic, Juntao Ke, Tze Y. Lim, Atlas Khan, Yask Gupta, Alejandra Perez, Zonghai Yan, Hila Milo Rasouly, Natalie Vena, Natalie Lippa, Jessica L. Giordano, Marijan Saraga, Mirna Saraga-Babic, Rik Westland, Monica Bodria, Giorgio Piaggio, Pavan K. Bendapudi, Alejandro D. Iglesias, Ronald J. Wapner, Velibo Tasic, Fan Wang, Iuliana Ionita-Laza, Gian Marco Ghiggeri, Krzysztof Kiryluk, Rosemary Sampogna, Cathy L. Mendelsohn, Vivette D. D'Agati, Ali G. Gharavi, Simone Sanna-Cherchi
Summary: This study clarifies the association between DSTYK variants and congenital anomalies of the kidney and urinary tract (CAKUT) through mouse and human studies. The results show low penetrance of DSTYK variants and their association with neurological disorders. These data support the causality of DSTYK variants and highlight the need for large-scale sequencing studies.
GENETICS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Pedro Antunes Pousa, Tamires Sara Campos Mendonca, Larissa Marques Fonseca, Eduardo Araujo Oliveira, Andre Rolim Belisario, Ana Cristina Simoes e Silva
Summary: This study aimed to evaluate the association between ACE gene I/D polymorphisms, circulating levels of Ang II, and CAKUT. The study concluded that ACE I/D polymorphisms were not associated with CAKUT or specific CAKUT phenotypes, and there were no significant differences in plasma levels of Ang II between CAKUT patients and controls.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pediatrics
Shane F. Batie, Caitlin T. Coco, Shreedhar Reddy, Karen Pritzker, Janelle M. Traylor, Jennifer D. Tracy, Yvonne Y. Chan, Irina Stanasel, Bruce J. Schlomer, Micah A. Jacobs, Linda A. Baker, Craig A. Peters
Summary: This study aimed to evaluate the impact of ureteral stents with extraction strings on the risk of urinary tract infection (UTI) after pediatric ureteral reconstruction. The results showed that the use of ureteral stents with extraction strings did not increase the risk of UTI for children without a history of UTI.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Review
Pediatrics
Geminiganesan Sangeetha, Ramesh Babu
Summary: This meta-analysis compared the accuracy of common urinary biomarkers for ureteropelvic junction obstruction (UPJO) and found that CA 19-9 had the highest sensitivity, NGAL had the highest specificity, and CA 19-9 had the highest overall accuracy.
PEDIATRIC NEPHROLOGY
(2022)
Article
Pediatrics
Mariana A. Vasconcelos, Ana Carmen Q. Mendonca, Enrico A. Colosimo, Noureddin Nourbakhsh, Hercilio Martelli-Junior, Ludmila R. Silva, Maria Christina L. Oliveira, Clara C. Pinhati, Robert H. Mak, Ana Cristina Simoes e Silva, Eduardo A. Oliveira
Summary: This study aimed to characterize the clinical outcomes and risk factors for COVID-19-related death in hospitalized pediatric patients with kidney diseases (KD). The results showed that pediatric patients with KD had a higher risk of death compared with non-KD patients. The higher risk was associated with low oxygen saturation at admission, living in socioeconomically disadvantaged regions, and presence of other pre-existing comorbidities.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Raphael Figuiredo Dias, Mateus da Costa Monteiro, Renata Aguiar Menezes Silva, Mirella Monique Lana Diniz, Ana Cristina Simaes Silva
Summary: This case report presents a rare pediatric case of probable tacrolimus-induced Bartter-like syndrome in a renal transplanted boy. It highlights the importance of considering losing-salt tubulopathies, such as Bartter syndrome, in transplanted patients who develop dehydration and hydroelectrolytic disorders after starting nephrotoxic immunosuppressive drugs like tacrolimus.
CURRENT DRUG SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Castello Branco, Bruno Wilnes, Pedro Alves Soares Vaz de Castro, Caio Ribeiro Vieira Leal, Ana Cristina Silva
Summary: The posterior urethral valve (PUV) is a rare but significant cause of congenital obstruction of the lower urinary tract in pediatrics, leading to chronic kidney disease (CKD). New diagnostic strategies, including biomarkers, are essential for better prognosis assessment in PUV patients.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Eduarda Almeida Wakabayashi, Alexandre Negrao Pantaleao, Renata Araujo Avendanha, Felipe Baptista Brunheroto, Ana Cristina Silva
Summary: The present review summarizes and updates the scientific literature on congenital solitary functioning kidney (SFK), discussing its pathophysiology, diagnosis, complications, prognosis, role of novel urinary biomarkers, treatment, and follow-up. The natural history of congenital SFK is still unresolved, and there is limited research on novel urinary biomarkers in this population.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sara Tavares Araujo, Clara Tavares Araujo, Rafael Silva e Castro, Lara Machado de Oliveira Brugger, Nathalia Gualberto Souza e Silva, Debora Marques de Miranda, Ana Cristina Simoes e Silva
Summary: This review examines neurologic manifestations in COVID-19 and investigates neuroimaging markers for early diagnosis and prognosis. Magnetic resonance imaging (MRI) is the most commonly used method for observing neurologic injuries. The manifestations may result from direct viral infection or indirect mechanisms. However, further population studies are needed to evaluate neurologic manifestations in individuals with different severities of COVID-19.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Obstetrics & Gynecology
Ana Carolina Cabral de Paula Machado, Livia de Castro Magalhaes, Suelen Rosa de Oliveira, Sergio Luiz Novi, Rickson C. Mesquita, Debora Marques de Miranda, Maria Candida F. Bouzada
Summary: This study compared adaptive behavior and functional cortical response to tactile stimulus in preterm and full-term infants using Test of Sensory Functions in Infants and functional Near-Infrared Spectroscopy (fNIRS). The results showed that preterm infants had poorer tactile reactivity at 6 months, but this difference was not observed at 12 months. At 12 months, preterm infants showed lower cortical response frequency in the premotor area.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Maria C. L. Oliveira, Enrico A. Colosimo, Mariana A. Vasconcelos, Hercilio Martelli-Junior, Robert H. Mak, Ludmila R. Silva, Clara C. Pinhati, Ana C. Simoes e Silva, Eduardo A. Oliveira
Summary: This study aimed to compare the risk of death among hospitalized children with asthma and healthy peers due to COVID-19. The findings showed that children with asthma and no comorbidities had a lower risk of death compared with healthy peers.
PEDIATRIC PULMONOLOGY
(2023)
Review
Pediatrics
Anna Luiza Braga Albuquerque, Rafael dos Santos Borges, Ana Flavia Conegundes, Erika Emmylaine dos Santos, Frederico Moreira Man Fu, Clara Tavares Araujo, Pedro Alves Soares Vaz de Castro, Ana Cristina Simoes e Silva
Summary: Fanconi-Debre-de Toni syndrome is a disease that affects the function of the proximal convoluted tubule in the kidney. It can be inherited or secondary to systemic disorders. In children, it is often associated with energy supply disorders, and early diagnosis and treatment can improve prognosis and quality of life.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Urology & Nephrology
Fernanda Nunes Coelho Siqueira Pinto, Jose de Bessa Junior, Jose Murillo Bastos Netto, Glaucia Cristina Medeiros Dias, Monica Maria de Almeida Vasconcelos, Eleonora Moreira Lima, Tailly de Souza Almeida, Ana Cristina Simoes e Silva, Flavia Cristina de Carvalho Mrad
Summary: The objective of this study was to translate, cross-culturally adapt, and validate the Vancouver Symptom Score (VSS) for bladder and bowel dysfunction (BBD) in Brazilian children and adolescents. The translated VSS was found to be a reliable and valid tool for identifying symptoms of BBD in Brazilian children and adolescents aged five to 16 years.
INTERNATIONAL BRAZ J UROL
(2023)
Article
Pediatrics
Raissa T. Boato, Marcos B. Aguiar, Robert H. Mak, Enrico A. Colosimo, Ana Cristina Simoes e Silva, Eduardo A. Oliveira
Summary: This case-control study found that consanguinity, positive family history, and maternal hypertension were associated with congenital anomalies of the kidney and urinary tract (CAKUT). However, these risk factors were rare in the study cohort and most cases were sporadic forms.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ana Cristina Simoes e Silva, Eduardo A. A. Oliveira, Wai W. W. Cheung, Robert R. H. Mak
Summary: Redox signaling alterations contribute to CKD-associated cachexia. This review summarizes studies on the redox pathophysiology in CKD-associated cachexia and muscle wasting, and discusses potential therapeutic approaches using antioxidant and anti-inflammatory molecules to restore redox homeostasis. Antioxidant molecules have been studied in experimental models and patients with CKD, and oxidative stress is increased in CKD due to factors such as uremic toxins, inflammation, and metabolic and hormone alterations. Rehabilitation and anti-inflammatory molecules have shown beneficial effects for CKD-associated cachexia, and experimental studies have shown the importance of oxidative stress through the use of antioxidant therapies. Further studies are needed for potential therapies involving antioxidant therapy.
Review
Biology
Joao Pedro Thimotheo Batista, Andre Oliveira Vilela de Faria, Thomas Felipe Silva Ribeiro, Ana Cristina Simoes e Silva
Summary: Diabetic cardiomyopathy is characterized by myocardial dysfunction in type 2 diabetes patients without traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease. The activation of the renin-angiotensin system (RAS), oxidative stress, lipotoxicity, maladaptive immune responses, imbalanced mitochondrial dynamics, impaired myocyte autophagy, increased myocyte apoptosis, and fibrosis all contribute to the development of diabetic cardiomyopathy. Research has shown that the RAS plays a crucial role in this condition, with over-activation of the classical RAS axis leading to increased oxidative stress, fibrosis, and cardiac remodeling, while angiotensin-(1-7) has a protective effect. ACE inhibitors and angiotensin receptor blockers have been shown to improve heart functioning and reduce the occurrence of diabetic cardiomyopathy.
Review
Pediatrics
Thiago M. A. Veiga, Pedro E. P. Carvalho, Felipe S. L. Machado, Gabriel V. Porto, Luiza F. Raymundo, Ana Cristina Simoes e Silva
Summary: This study aims to investigate if Antibiotic Prophylaxis (AP) can prevent wound and/or systemic infection in pediatric patients who underwent Percutaneous Endoscopic Gastrostomy (PEG). Four studies, including one randomized controlled trial (RCT), with a total of 568 patients were included. The use of AP during PEG reduced the incidence of systemic infection, but no statistical difference was found for wound infection and the composite outcome of any kind of infection.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Aislander Junio da Silva, Ana Cristina Santos dos Lopes, Ana Paula Lucas Mota, Ana Cristina Simoes e Silva, Luci Maria Sant'Ana Dusse, Patricia Nessralla Alpoim
Summary: This study aims to investigate the association between blood cell count indexes and pediatric CKD etiology and staging. The results showed that LMR and SIRI indexes showed promising results in the evaluation of inflammation.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Psychiatry
Andre Luiz de Carvalho Braule Pinto, Alexandre Luiz de Oliveira Serpa, Rafaela Ferreira Guatimosim, Danielle Souza Costa, Jonas Jardim de Paula, Antonio Geraldo da Silva, Alexandre Paim Diaz, Debora Marques de Miranda, Leandro Fernandes Malloy-Diniz
Summary: This study aimed to assess the impact of the COVID-19 pandemic on the psychological distress and PTSD symptoms of Brazilian healthcare workers. Through multiple assessments at different time points, two subgroups of healthcare workers with high-PTSS and low-PTSS profiles were identified. Being female, fear of contamination, and fearing financial problems were strong predictors of changes in the profile.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
