Journal
NEPHROLOGY
Volume 18, Issue 3, Pages 177-179Publisher
WILEY-BLACKWELL
DOI: 10.1111/nep.12027
Keywords
nephrogenesis; transcriptional networks; nephron progenitor programmes
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Funding
- NIDDK NIH HHS [R37 DK054364, F32 DK085959, R01 DK054364] Funding Source: Medline
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Nephrogenesis is dependent on the input of several transcriptional regulatory networks. However, the details of how these networks operate and converge to facilitate nephron progenitor specific programmes are largely unknown. To this end, recent studies have focused on identifying the precise regulatory mechanisms that modulate progenitor maintenance and induction. Continued focus on this area of research will help identify nephrogenic programmes which could be manipulated for therapeutic intervention of kidney disease.
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