Article
Immunology
Zijian Zhang, Yan Qin, Yicun Wang, Shuai Li, Xiaopeng Hu
Summary: This study predicted the differential expression of monocytes associated with rejection by analyzing the transcriptome data of peripheral blood mononuclear cells. A novel gene, ISG15, was found to be associated with rejection and showed a critical role in promoting T cell proliferation. The results of this study have important implications for non-invasive diagnosis and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Xiaohong Xiang, Jiefu Zhu, Gang Zhang, Zhengwei Ma, Man J. Livingston, Zheng Dong
Summary: The study demonstrates that p53 plays a critical role in kidney injury associated with cold storage/transplantation, and inhibiting p53 can improve the histology and function of transplanted kidneys, showing potential as a therapeutic target for kidney transplantation.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yunhui Li, Bin Liang
Summary: This study analyzed the levels of circulating dd-cfDNA in different types of graft rejection and evaluated its diagnostic potential in predicting graft rejection after lung transplantation. The results showed that circulating dd-cfDNA levels were significantly higher in graft rejection, ACR, and AMR compared to non-rejection. Circulating dd-cfDNA could be used as a non-invasive biomarker to distinguish patients with graft rejection from normal stable controls.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Raphael Porret, Raphael P. H. Meier, Josip Mikulic, Manuel Pascual, Vincent Aubert, Thomas Harr, Dela Golshayan, Yannick D. D. Muller, Swiss Transplant Cohort Study
Summary: The study found that atopy is associated with better long-term patient and graft survival after kidney transplantation, independently of age and living donor donation. However, it does not affect the occurrence of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Karim El Sakhawi, Giovanna Melica, Anne Scemla, Dominique Bertrand, Cyril Garrouste, Paolo Malvezzi, Philippe Remy, Anissa Moktefi, Alexandre Ingels, Cecile Champy, Jean-Daniel Lelievre, David Kheav, Antoine Morel, David Mokrani, Philippe Attias, Philippe Grimbert, Marie Matignon
Summary: The study found that the switch from CNI to belatacept in HIV-positive kidney allograft recipients may increase long-term kidney allograft survival rates. Results showed that the conversion treatment did not increase the risk of HIV replication after a year, but the importance of patient medication compliance and adverse events should be noted.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Transplantation
Eva Schrezenmeier, Mia Mueller, Frank Friedersdorff, Dmytro Khadzhynov, Fabian Halleck, Oliver Staeck, Michael Durr, Kun Zhang, Kai-Uwe Eckardt, Klemens Budde, Lukas J. Lehner
Summary: This study analyzed the severity of delayed graft function (DGF) and its impact on transplant outcomes in 627 deceased-donor kidney transplant recipients. The results showed that the duration of DGF had a significant effect on 10-year death-censored graft survival, especially in kidneys with a Kidney Donor Profile Index (KDPI) less than 85%. However, short duration DGF (0-1 day) had comparable results to no DGF.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Immunology
Meng Dou, Chenguang Ding, Bingxuan Zheng, Ge Deng, Kun Zhu, Cuixiang Xu, Wujun Xue, Xiaoming Ding, Jin Zheng, Puxun Tian
Summary: This study identified feature immune-related genes associated with graft rejection and developed a prognostic model that showed good sensitivity and specificity in predicting 1- and 3-year kidney graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Didi Chen, Xinyi Wu, Congying Xie
Summary: This report presents a case of a kidney transplant recipient experiencing acute allograft rejection after undergoing immunotherapy, but eventually achieving complete remission. This suggests that organ transplant patients need to be carefully assessed when receiving ICIs therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Carlos E. Arias-Cabrales, Marta Riera, Maria Jose Perez-Saez, Javier Gimeno, David Benito, Dolores Redondo, Carla Burballa, Marta Crespo, Julio Pascual, Eva Rodriguez
Summary: Ischaemia-reperfusion damage is a major cause of delayed graft function (DGF). The activation of complement system is involved in experimental I/R injury, with SC5b-9 levels and deposits of C3b, FH serving as potential markers for DGF severity in kidney transplant patients.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Immunology
Ahmad Halawi, Abdullah B. El Kurdi, Katherine A. Vernon, Zhabiz Solhjou, John Y. Choi, Anis J. Saad, Nour K. Younis, Rania Elfekih, Mostafa Tawfeek Mohammed, Christa A. Deban, Astrid Weins, Reza Abdi, Leonardo V. Riella, Sasha A. De Serres, Paolo Cravedi, Anna Greka, Pierre Khoueiry, Jamil R. Azzi
Summary: By conducting snRNA-seq on kidney allograft samples, we identified the role of T-cells, endothelial cells (ECs), and pericytes in cellular rejection progression. The analysis showed that the borderline sample represents an early rejection stage, allowing for the study of early stages of cellular rejection. Furthermore, we discovered novel pathways and interactions involved in alloimmune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Christian Bach, Karl X. Knaup, Markus Herrmann, Mandy Krumbiegel, Frederick Pfister, Maike Buettner-Herold, Martin Steffen, Daniel Zecher, Kai Lopau, Karen Schneider, Anne Dieterle, Kerstin Amann, Andre Reis, Mario Schiffer, Bernd M. Spriewald, Michael S. Wiesener
Summary: Antibody-mediated rejection (AMR) poses a significant challenge to long-term kidney transplantation, primarily caused by donor-specific HLA antibodies. The lack of available donor DNA often hinders the assessment of HLA antibody specificity. The study demonstrates the feasibility and diagnostic value of establishing donor renal tubular cell cultures from recipient's urine to solve this issue and accurately determine donor-specificity of HLA antibodies in kidney transplant patients.
TRANSPLANT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
Roland Roller, Manuel Mayrdorfer, Wiebke Duettmann, Marcel G. Naik, Danilo Schmidt, Fabian Halleck, Patrik Hummel, Aljoscha Burchardt, Sebastian Moeller, Peter Dabrock, Bilgin Osmanodja, Klemens Budde
Summary: This study developed a clinical decision support system (CDSS) for detecting rejection and graft failure risks in kidney transplant patients. The CDSS was found to detect different at-risk patients compared to physicians, and while physicians' predictions were influenced by the CDSS, performance did not significantly improve.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Transplantation
Lina Maria Serna-Higuita, Andrea Della Penna, Martina Guthoff, Nils Heyne, Sandra Beer-Hammer, Silvio Nadalin, Peter Martus, Alfred Koenigsrainer, Markus Quante
Summary: This study analyzed the clinical outcomes of obese transplantation recipients under different immunosuppressive protocols. The findings showed that in obese recipients treated with mTORi-Tac, the incidence of acute rejection was lower. However, in obese recipients treated with Tac-MMF, there was an increased risk of cardiovascular events and mortality due to infection.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Aleksandar Senev, Bryan Ray, Evelyne Lerut, Jayasree Hariharan, Christine Heylen, Dirk Kuypers, Ben Sprangers, Marie-Paule Emonds, Maarten Naesens
Summary: This study found that patients highly and broadly sensitized to non-HLA targets are at increased risk of ABMR histology after kidney transplantations in the absence of HLA-DSA. Additionally, some pretransplant non-HLA autoantibodies are individually associated with increased rates of ABMR histology. However, further studies are needed to determine whether these associations are clinically relevant and represent causality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Hywel Lloyd, Grace Li, Andrew Tomlin, Murray W. Tilyard, Robert Walker, John Schollum
Article
Urology & Nephrology
Neil A. Hoye, Luke C. Wilson, David L. Jardine, Robert J. Walker
SEMINARS IN DIALYSIS
(2019)
Article
Multidisciplinary Sciences
J. A. Hurcombe, P. Hartley, A. C. Lay, L. Ni, J. J. Bedford, J. P. Leader, S. Singh, A. Murphy, C. L. Scudamore, E. Marquez, A. F. Barrington, V. Pinto, M. Marchetti, L. -F. Wong, J. Uney, M. A. Saleem, P. W. Mathieson, S. Patel, R. J. Walker, J. R. Woodgett, S. E. Quaggin, G. I. Welsh, R. J. M. Coward
NATURE COMMUNICATIONS
(2019)
Review
Urology & Nephrology
Robert J. Walker, Malama Tafunai, Amrish Krishnan
SEMINARS IN NEPHROLOGY
(2019)
Article
Urology & Nephrology
Bronwen McNoe, John B. W. Schollum, Sarah Derrett, Mark R. Marshall, Andrew Henderson, Ari Samaranayaka, Robert J. Walker
Article
Public, Environmental & Occupational Health
Isabelle H. S. Kuan, Ruth L. Savage, Stephen B. Duffull, Robert J. Walker, Daniel F. B. Wright
Article
Multidisciplinary Sciences
Catherine J. Leader, Mohammed Moharram, Sean Coffey, Ivan A. Sammut, Gerard W. Wilkins, Robert J. Walker
Editorial Material
Oncology
John Leader, Jennifer Bedford, Robert J. Walker
ANNALS OF TRANSLATIONAL MEDICINE
(2019)
Article
Genetics & Heredity
S. M. Ali Hosseini Rad, Grace Min Yi Tan, Aarati Poudel, Kevin He, Alexander D. McLellan
Article
Multidisciplinary Sciences
Ali Hosseini S. M. Rad, Aarati Poudel, Grace Min Yi Tan, Alexander D. McLellan
Article
Immunology
Haniyeh Aghababa, Yi Tian Ting, Devaki Pilapitiya, Jacelyn M. S. Loh, Paul G. Young, Thomas Proft
Summary: This study identified a novel immune evasion factor in Streptococcus pyogenes that interferes with complement function by binding to several complement proteins. This is the first example of a S. pyogenes virulence factor binding to several different target proteins via glycan-dependent interactions.
Editorial Material
Cell Biology
Seyed Mohammad Ali Hosseini Rad, Joshua Colin Halpin, Supannikar Tawinwung, Koramit Suppipat, Nattiya Hirankarn, Alexander D. McLellan
Summary: Advances in CAR-T cell therapy have improved the treatment of certain cancers. The persistence of CAR-T cells in patients is linked to mitochondrial fitness, and miRNAs could be used for mitochondrial reprogramming to enhance CAR-T cell function.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Genetics & Heredity
Sarah C. Saunderson, S. M. Ali Hosseini-Rad, Alexander D. McLellan
Summary: Tetracycline-inducible systems are widely used control elements for mammalian gene expression. The G72V mutation in the rtTA-M2 tetracycline activator reduces basal level expression and increases fold-induction. Sensitivity enhancing mutations compensate for the loss of responsiveness caused by the G72V mutation without compromising promoter tightness.
Article
Oncology
Grace Min Yi Tan, Aarati Poudel, Seyed Mohammad Ali Hosseini Rad, Alexander Donald McLellan
Summary: This study evaluated the impact of c-FLIPp43 on anti-apoptosis and anti-tumor immunity in Her2-CAR T cells, finding that the expression of c-FLIPp43 reduces CAR activity and anti-tumor efficacy of T cells.
Article
Cell Biology
Lachlan J. Dobson, Sarah C. Saunderson, Samuel W. J. Smith-Bell, Alexander D. McLellan
Summary: Artificial antigen-presenting cells (aAPCs) are cost-effective and convenient tools for expanding CAR-bearing T cells and NK cells. We developed a single-step technique using Sleeping Beauty (SB)-based vectors with antibiotic selection to overcome difficulties in accessing existing aAPC lines and isolate stable aAPC clones. Our SB vectors allow for the surface expression of CD86, 4-1BBL, membrane-bound (mb) interleukin (IL)-15, and mbIL-21 in aAPCs, which successfully expanded NK cells to high purity. The multivector kit set we developed enables in-house production of effective aAPCs for the in vitro expansion of primary cells.
IMMUNOLOGY AND CELL BIOLOGY
(2023)