Review
Oncology
Kim T. Vuong, Catherine Joseph, Joseph R. Angelo
Summary: While AKI after HCT is well-described in pediatric patients, limited literature exists regarding the long-term renal consequences, development of CKD, and CKD care in these patients. CKD affects almost 50% of patients after HCT with various causes, and as renal function declines, mortality increases. This review aims to summarize definitions, etiologies, and management strategies for AKI and CKD post-HCT, with a focus on early identification, intervention, and discussion of ESKD and renal transplant.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Anders Nikolai Orsted Schultz, Jan Dominik Kampmann, Kristian Kidholm, Caroline Moos, Eithne Hayes Bauer
Summary: This article aims to conduct a scoping review to examine the evidence on mHealth education for patients with chronic kidney disease (CKD). The review will explore the feasibility, effectiveness outcomes and outcome measures, as well as patient and/or provider perception and implementation challenges. The results of this review will be published in a peer-reviewed scientific journal.
Review
Urology & Nephrology
Nestor Oliva-Damaso, Pierre Delanaye, Elena Oliva-Damaso, Juan Payan, Richard J. Glassock
Summary: Chronic kidney disease and kidney failure are global health problems, with unequal access to treatment between countries. Different referral guidelines lead to varied outcomes for CKD patients. Non-age-adapted diagnostic criteria can cause overdiagnosis in the elderly and underdiagnosis in young patients. Non-age-adapted recommendations can result in unnecessary referral for elderly patients with mild disease, ignoring potential interventions for younger patients. The shortage of nephrology workforce leads to focused referral for advanced CKD stages, but changes are needed to reduce the burden of kidney failure. The Kidney Failure Risk Equation is a novel tool that can guide wiser referrals and impact patients.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Geriatrics & Gerontology
Erez Sarel, Naomi Nacasch, Ilan Rozenberg, Rachel Heffez Ayzenfeld, Sydney Benchetrit, Jacob Feldman, Keren Cohen-Hagai
Summary: This study aimed to assess the impact of chronic kidney disease (CKD) on the efficacy of rehabilitation in the geriatric population. The results showed that patients with advanced CKD had lower functional independence at admission and discharge, shorter duration of rehabilitation, and more dependence at discharge compared to patients with early CKD. Therefore, implementing a multidisciplinary team focused on the specific needs of geriatric CKD patients may lead to better rehabilitative outcomes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Urology & Nephrology
Christopher B. Pierce, Alvaro Munoz, Derek K. Ng, Bradley A. Warady, Susan L. Furth, George J. Schwartz
Summary: New glomerular filtration rate estimating equations were developed and validated for children and young adults, considering sex and age factors. Equations with age-dependent K values significantly reduced bias, especially in young children and young adults.
KIDNEY INTERNATIONAL
(2021)
Review
Cell Biology
Mengsi Hu, Qianhui Wang, Bing Liu, Qiqi Ma, Tingwei Zhang, Tongtong Huang, Zhimei Lv, Rong Wang
Summary: Chronic kidney disease (CKD) and cancer have a complex relationship, which may be associated with chronic inflammation, accumulation of carcinogenic compounds, and impaired DNA repair. Understanding this field can be helpful for both nephrologists and oncologists in clinical practice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Urology & Nephrology
Alberto Martinez-Castelao, Maria Jose Soler, Jose Luis Gorriz Teruel, Juan F. Navarro-Gonzalez, Beatriz Fernandez-Fernandez, Fernando de Alvaro Moreno, Alberto Ortiz
Summary: Despite the decrease in age-standardized rates of diabetes mellitus-related complications, the incidence of advanced chronic kidney disease has not shown a clear reduction. Early detection of diabetic kidney disease is crucial for reducing complications, morbidity, and mortality.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Oncology
Matthieu Delaye, Adrien Rousseau, Melanie Try, Christophe Massard, Luca Campedel, Marc Hilmi, Corinne Bagnis
Summary: The objective of this study was to determine the proportion and criteria of phase 3 clinical trials excluding patients with Chronic Kidney Disease (CKD) in systemic therapy for prostate, breast, lung, or colorectal cancer. The study found that the majority of trials had renal exclusion criteria, but many of them were undefined. Only disease site was associated with exclusion of patients with CKD.
Review
Biochemistry & Molecular Biology
Ulla T. Schultheiss, Robin Kosch, Fruzsina Kotsis, Michael Altenbuchinger, Helena U. Zacharias
Summary: Kidney diseases present a major challenge in global health, with their complexity hindering the understanding of underlying mechanisms and optimal patient care. Metabolomics, studying small organic compounds in biological specimens, is becoming increasingly important in nephrology research. Conducting metabolomics studies in human kidney disease cohorts requires thorough knowledge of study planning, sample collection, data processing, statistical analysis, and interpretation of results within a biomedical context.
Article
Medicine, General & Internal
Frederik Husum Marup, Christian Daugaard Peters, Jeppe Hagstrup Christensen, Henrik Birn
Summary: This study aims to investigate whether adding a potassium binder (patiromer) can improve the treatment outcomes, including the use of MRA, in patients with albuminuric CKD. The study will also examine the feasibility of potassium binders in patients with CKD.
Article
Surgery
Julio C. Santana, Harish Doppalapudi, Christopher W. Ives, Ayman A. Farag, Dana Rizk, Vineeta Kumar, Ami E. Iskandrian, Fadi G. Hage
Summary: Silent myocardial infarction (SMI) on 12-lead ECG is associated with increased cardiovascular disease (CVD) risk in patients awaiting renal transplantation (RT). This study evaluated the prevalence of SMI in patients undergoing RT and its prognostic value after RT.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Pediatrics
Mirjam Mocnik, Sonja Golob Jancic, Natasa Marcun Varda
Summary: The transition of patients with normal or mildly decreased renal function to adult care and management is often neglected, highlighting the importance of regular education for these patients.
Article
Medicine, General & Internal
Zvi Shimoni, Paul Froom, Jochanan Benbassat
Summary: The study revealed that proteinuria is common in hospitalized patients, weakly associated with eGFR, and mainly related to other factors that could lead to false-positive results. The clinical utility of follow-up for proteinuria post-discharge is questionable due to its high frequency and potential for significant healthcare costs.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Francesca De Santis, Andrea Boari, Francesco Dondi, Paolo Emidio Crisi
Summary: Chronic kidney disease is common in adult and aged dogs and cats, requiring lifelong medication to maintain quality of life; however, guidance and literature on drug dosage adjustment in dogs and cats with chronic kidney disease are often lacking.
Article
Urology & Nephrology
Andrew Bakshi, Julia Jefferis, Rory Wolfe, James B. Wetmore, John J. McNeil, Anne M. Murray, Kevan R. Polkinghorne, Andrew J. Mallett, Paul Lacaze
Summary: The risk of chronic kidney disease (CKD) increases with age and is influenced by genetic and environmental factors. Polygenic scores (PGS) for CKD-related traits have shown potential for risk prediction in older adults. This study assessed the performance of PGS for CKD-related traits in a well-characterized cohort of healthy older individuals.
KIDNEY INTERNATIONAL
(2023)
