Article
Pediatrics
Bo Lyun Lee, Dawn Gano, Elizabeth E. Rogers, Duan Xu, Stephany Cox, A. James Barkovich, Yi Li, Donna M. Ferriero, Hannah C. Glass
Summary: Neonatal watershed (WS) injury is associated with decreased cognitive abilities in adolescents, potentially leading to long-term intellectual challenges. Children with post-neonatal epilepsy and cerebral palsy showed the worst cognitive outcomes.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Vishnu-Priya Akula, Achyuth Sriram, Sherian Xu, Eileen Walsh, Krisa Van Meurs, Matthew Cranshaw, Michael Kuzniwiecz
Summary: Mild neonatal encephalopathy may lead to adverse short- and long-term outcomes, including developmental disorders and motor and speech delay. The group with mild encephalopathy had significantly higher rates of adverse outcomes compared to the unexposed group.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Robert Galinsky, Simerdeep K. Dhillon, Sharmony B. Kelly, Guido Wassink, Joanne O. Davidson, Christopher A. Lear, Lotte G. van den Heuij, Laura Bennet, Alistair J. Gunn
Summary: Maternal magnesium sulphate (MgSO4) treatment before preterm birth for neuroprotection is controversial due to limited evidence of long-term neuroprotection. In this study, preterm fetal sheep received MgSO4 infusion before hypoxia-ischaemia induced by umbilical cord occlusion. Although MgSO4 showed moderate improvements in white and grey matter gliosis and myelin density, it did not improve EEG maturation, neuronal or oligodendrocyte survival.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell & Tissue Engineering
Joanne O. Davidson, Lotte G. van den Heuij, Mhoyra Fraser, Guido Wassink, Suzanne L. Miller, Rebecca Lim, Euan M. Wallace, Graham Jenkin, Alistair J. Gunn, Laura Bennet
Summary: Even up to 24 hours after hypoxia-ischemia, a single infusion of hAECs shows anti-inflammatory, anti-gliotic, and neuroprotective effects in preterm fetal sheep. However, the protection on white matter is limited, and there is no improvement in the recovery of EEG power.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Kasper J. Kyng, Sigrid Kerrn-Jespersen, Kristine Bennedsgaard, Torjus Skajaa, Michael Pedersen, Ida E. Holm, Tine B. Henriksen
Summary: The study indicated that RIPC could reduce brain lactate/N-acetylaspartate ratios at 72 hours after HI, but had no effect on diffusion-weighted imaging, neuropathology scores, neurological recovery, or mortality. RIPC may have a selective metabolic effect by ameliorating lactate accumulation without improving other short-term outcomes.
PEDIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Tommi Ala-Kurikka, Alexey Pospelov, Milla Summanen, Aleksander Alafuzoff, Samu Kurki, Juha Voipio, Kai Kaila
Summary: A rat model of birth asphyxia was developed to mimic clinical cases, showing that seizures are triggered after exposure to hypoxia, rather than during the insult.
Article
Obstetrics & Gynecology
C. E. Tacke, W. Onland, P. C. A. M. Bakker, F. Groenendaal, A. N. Rosman, L. Broeders, J. V. Been, A. C. J. Ravelli
Summary: The risk of low 5-minute Apgar scores in singleton births has increased in the Netherlands over the past decade, with instrumental vaginal delivery and emergency cesarean section showing the highest relative increase.
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Patricia Berg, Michaela Granfors, Charlotta Riese, Aengla Mantel
Summary: This retrospective cohort study investigated the association between clinical and laboratory characteristics of chorioamnionitis during term gestation deliveries and adverse neonatal outcomes. The results showed that elevated inflammatory laboratory markers were associated with neonatal infection and asphyxia-related complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Pediatrics
Alexandra Bower, Perrine Lorain, Gilles Kayem, Marc Dommergues, Laurence Foix-L'Helias, Isabelle Guellec
Summary: The study found that newborns with pathological foetal acidemia but without moderate or severe HIE may have metabolic disorders, require organ support, hospitalization, and blood sampling for detecting biological anomalies. Prospective studies are needed to establish consensus guidelines for managing this vulnerable population.
Article
Biochemistry & Molecular Biology
Ewelina Bratek-Gerej, Apolonia Ziembowicz, Elzbieta Salinska
Summary: This study found that activation of group II mGlu receptors can prevent brain damage and regulate apoptosis and neuroprotective mechanisms in experimental birth asphyxia. Agonists LY379268 and NAAG can inhibit excessive glutamate release and apoptotic damage, and restore the concentration of neurotrophins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Joyce F. Mwatonoka, Shakilu Jumanne, Azan Nyundo, Carsten Kruger
Summary: Hypoxic-ischaemic encephalopathy (HIE) is associated with a high incidence of poor outcomes in resource-limited settings. Improved quality of neonatal care is necessary to enhance outcomes, particularly for newborns with severe HIE, a history of aspiration, referred from other facilities, a 5th-min APGAR score of <7, and an abnormal heart rate on admission.
Article
Medicine, General & Internal
Waqas Shakir, Abdur-Rehman, M. Sohail Arshad, Nazia Fatima
Summary: The objective of this study was to investigate the burden and outcome of cardiovascular dysfunction in term newborns with birth asphyxia. The results showed that among 171 term newborns, 35.1% had cardiovascular dysfunction, and some of them died. Therefore, there was a significant association between cardiovascular dysfunction in asphyxiated neonates and poor outcomes.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gian Pietro Sechi, Flaminia Bardanzellu, Maria Cristina Pintus, Maria Margherita Sechi, Maria Antonietta Marcialis, Vassilios Fanos
Summary: This review discusses the potential therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE), highlighting its antioxidant properties and ability to rescue mitochondrial function. It suggests a synergistic effect between thiamine treatment and therapeutic hypothermia.
Article
Environmental Sciences
Yun-Fei Su, Cheng Li, Jing-Jing Xu, Fang-Yue Zhou, Tao Li, Cong Liu, Yan-Ting Wu, He-Feng Huang
Summary: Despite previous research on the effect of air pollutants on preterm birth (PTB), this study investigated the impact of particulate matter (PM) on PTB subtypes in Shanghai. Short-term exposure to PM2.5 and PM10 was positively associated with PTB and spontaneous preterm birth (sPTB) at a lag of 2 days. Long-term exposure to PM2.5 and PM10 in the 3rd trimester and 3 months before conception was associated with greater odds of sPTB and medically indicated preterm birth (miPTB). The findings suggest that different underlying causes of PTB may influence the susceptibility windows of PM exposure.
Article
Multidisciplinary Sciences
Albertine Enjema Njie, Winstone Mokaya Nyandiko, Phinehas Ademi Ahoya, Jude Suh Moutchia
Summary: This study compared the effectiveness of APGAR scores in diagnosing birth asphyxia with the gold standard, and identified healthcare provider factors that affect the ineffective use of APGAR scores. The results showed that APGAR scores had low sensitivity and positive predictive values. Healthcare provider factors associated with ineffective use of APGAR scores included instrumental delivery, lack of access to APGAR scoring charts, and neonatal resuscitation.
Review
Pediatrics
Burcu Cebeci, Thomas Alderliesten, Jannie P. Wijnen, Niek E. van der Aa, Manon J. N. L. Benders, Linda S. de Vries, Agnes van den Hoogen, Floris Groenendaal
Summary: This review assessed the associations between cerebral H-1-MRS and neurodevelopment after preterm birth, finding that NAA/Cho is the most common metabolite ratio associated with motor, language, and cognitive outcomes.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Corline E. J. Parmentier, Sylke J. Steggerda, Lauren C. Weeke, Monique Rijken, Linda S. De Vries, Floris Groenendaal
Summary: In a retrospective cohort study, all infants with perinatal asphyxia and early seizure onset who did not receive therapeutic hypothermia had MRI abnormalities and half died or had poor neurodevelopmental outcome.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Corline E. J. Parmentier, Linda S. de Vries, Niek E. van der Aa, Maria J. C. Eijsermans, Johanneke C. Harteman, Maarten H. Lequin, Henriette F. N. Swanenburg de Veye, Corine Koopman-Esseboom, Floris Groenendaal
Summary: This single-center retrospective cohort study aimed to determine the incidence of hypoglycemia in infants with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia, and its association with brain injury and neurodevelopmental outcomes. The results showed that over one-third of infants with HIE experienced hypoglycemia, which was correlated with higher levels of brain injury on MRI and lower cognitive function during the preschool age. Therefore, strategies to prevent hypoglycemia should be optimized in this population.
JOURNAL OF PEDIATRICS
(2022)
Letter
Obstetrics & Gynecology
L. S. de Vries, S. J. Steggerda, F. Groenendaal, F. M. Cowan
JOURNAL OF PERINATOLOGY
(2022)
Review
Clinical Neurology
K. M. E. Meys, L. S. de Vries, F. Groenendaal, S. D. Vann, M. H. Lequin
Summary: Despite their small size, mammillary bodies play a crucial role in supporting recollective memory. However, their significance is often overlooked in assessing memory-related neurological disorders, especially in infants and children. This literature review indicates that mammillary body pathology is present in pediatric populations with various conditions, as shown by signal change and atrophy on brain MR imaging. The main causes of pathology are thiamine deficiency, hypoxia-ischemia, direct damage, or deafferentation within the Papez circuit. Given their importance in memory processes, it is critical to optimize scanning protocols and include assessment of mammillary body status as a standard procedure.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Editorial Material
Pediatrics
Floris Groenendaal, Peter G. J. Nikkels
JORNAL DE PEDIATRIA
(2022)
Article
Medicine, General & Internal
Corline E. J. Parmentier, Linda S. de Vries, Floris Groenendaal
Summary: Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-)term newborns. Neuroimaging, including cranial ultrasonography and magnetic resonance imaging (MRI), plays a crucial role in assessing brain injury and predicting outcomes. Advanced imaging techniques such as diffusion tensor imaging and arterial spin labeling provide valuable information about the etiology and prognosis of brain injury.
Article
Pediatrics
Elif Keles, Pia Wintermark, Floris Groenendaal, Noor Borloo, Anne Smits, Annouschka Laenen, Djalila Mekahli, Pieter Annaert, Suzan Sahin, Mehmet Yekta Oncel, Valerie Chock, Didem Armangil, Esin Koc, Malcolm R. Battin, Adam Frymoyer, Karel Allegaert
Summary: There is a large variability in kidney function and injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia. Using serum creatinine centiles over postnatal age may provide more valuable information in these neonates. Understanding postnatal age-related patterns enables clinicians to better assess kidney function and tailor treatment.
Letter
Pediatrics
Karel Allegaert, Djalila Mekahli, Pia Wintermark, Floris Groenendaal, Noor Borloo, Annouschka Laenen, Pieter Annaert, Suzan Sahin, Mehmet Yekta Oncel, Valerie Y. Chock, Didem Armangil, Esin Koc, Malcolm R. Battin, Adam Frymoyer, Elif Keles, Anne Smits
Article
Pediatrics
Corline E. J. Parmentier, Maarten H. Lequin, Thomas Alderliesten, Henriette F. N. Swanenburg de Veye, Niek E. van der Aa, Jeroen Dudink, Manon J. N. L. Benders, Johanna C. Harteman, Corine Koopman-Esseboom, Floris Groenendaal, Linda S. de Vries
Summary: This study evaluated the evolution of brain injury observed on magnetic resonance imaging (MRI) in neonatal encephalopathy (NE) following perinatal asphyxia. A scoring system was developed to assess brain injury on 3-month MRI and its association with neurodevelopmental outcome. The study found that abnormalities in deep gray matter (DGM) on 3-month MRI, preceded by DGM abnormalities on neonatal MRI, were associated with 18- to 24-month outcome, indicating the potential usefulness of 3-month MRI in evaluating treatment efficacy.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Juliette Langeslag, Wes Onland, Douwe Visser, Floris Groenendaal, Linda de Vries, Anton H. van Kaam, T. R. de Haan
Summary: The study aimed to evaluate the predictive ability of multiple organ dysfunction (MOD) in asphyxiated neonates undergoing therapeutic hypothermia (TH) on mortality or neurodevelopmental impairment (NDI) at 24 months, and to identify peripartum variables associated with the onset of MOD. The results showed that MOD has low accuracy in predicting the 24-month outcome or its components, and may not be useful for prognostication. Signs of acid-base disturbance at birth and the use of epinephrine are associated with the development of MOD.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Obstetrics & Gynecology
C. E. Tacke, W. Onland, P. C. A. M. Bakker, F. Groenendaal, A. N. Rosman, L. Broeders, J. V. Been, A. C. J. Ravelli
Summary: The risk of low 5-minute Apgar scores in singleton births has increased in the Netherlands over the past decade, with instrumental vaginal delivery and emergency cesarean section showing the highest relative increase.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Angret de Boer, Paulin van Beek, Peter Andriessen, Floris Groenendaal, Marije Hogeveen, Julia Meijer, Sylvia Obermann-Borst, Wes Onland, Liesbeth Scheepers, Marijn Vermeulen, E. J. T. (Joanne) Verweij, Lien De Proost, Rosa Geurtzen
Summary: Predicting the outcomes of extremely preterm infants is challenging, and multivariable prognostic models can provide accurate estimates for clinicians, parents, and policymakers. These models can support the development of treatment guidelines at a population level and improve prenatal counselling conversations at an individual level. Considerations for developing these models include predictor and outcome measure selection, clinical impact assessment, and generalizability.
Article
Pediatrics
Laura A. Warmerdam, Gerda van Wezel-Meijler, Linda S. de Vries, Floris Groenendaal, Sylke J. Steggerda
Summary: This study compared cerebellar growth in premature infants who received dexamethasone or hydrocortisone to premature infants who did not receive postnatal corticosteroids. The results showed that both types of corticosteroid had a negative association with cerebellar growth, but had no evident negative associations with cerebral growth.
Article
Pediatrics
Juliette F. Langeslag, Floris Groenendaal, Stefan D. Roosendaal, Linda S. de Vries, Wes Onland, Mariska M. G. Leeflang, Paul F. C. Groot, Anton H. van Kaam, Timo R. de Haan
Summary: This study aimed to determine which MRI scoring system best predicts adverse outcomes in term infants with perinatal asphyxia at 24 months of age, and has the highest inter-rater reliability. The results showed that all four MRI scoring systems had good predictive accuracy for adverse outcomes, with the Weeke and Trivedi scores demonstrating the highest inter-rater reliability. Using high-quality MRI scans further improved prediction.
