Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway

Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats

(2017) Lingling Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Simultaneous determination and pharmacokinetics of danshensu, protocatechuic aldehyde, 4-hydroxy-3-methyloxyphenyl lactic acid and protocatechuic acid in human plasma by LC–MS/MS after oral administration of Compound Danshen Dripping Pills

(2017) Wei Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Simultaneous determination of eight Danshen polyphenols in rat plasma and its application to a comparative pharmacokinetic study of DanHong injection and Danshen injection

(2017) Xiuxue Li et al.   JOURNAL OF SEPARATION SCIENCE

Quantitatively metabolic profiles of salvianolic acids in rats after gastric-administration of Salvia miltiorrhiza extract

(2016) Zhanli Liu et al.   FITOTERAPIA

Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway

(2016) Chao Guo et al.   MOLECULAR NEUROBIOLOGY

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

(2015) Yow Keat Tham et al.   ARCHIVES OF TOXICOLOGY

Critical Roles of STAT3 in β-Adrenergic Functions in the HeartCLINICAL PERSPECTIVE

(2015) Wenjun Zhang et al.   CIRCULATION

Innovative Strategy in Treating Angina Pectoris with Chinese Patent Medicines by Promoting Blood Circulation and Removing Blood Stasis: Experience from Combination Therapy in Chinese Medicine

(2015) Xing-Jiang Xiong et al.   Current Vascular Pharmacology

Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway

(2015) Liang Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway

(2015) Ayman Mahmoud et al.   Drug Design Development and Therapy

Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats

(2014) Toru Miyoshi et al.   Cardiovascular Diabetology

Targeting Cardiac Hypertrophy

(2014) Egbert Bisping et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-Induced Cardiac Damage in Mice

(2013) Jian-ping Zhang et al.   PLANTA MEDICA

Protocatechuic aldehyde inhibits migration and proliferation of vascular smooth muscle cells and intravascular thrombosis

(2012) Chang Yoon Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-inflammatory Effect of Protocatechuic Aldehyde on Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

(2012) Guo Wei et al.   INFLAMMATION

STAT3 Activation in Pressure-Overloaded Feline Myocardium: Role for Integrins and the Tyrosine Kinase BMX

(2012) Christopher D. Willey et al.   International Journal of Biological Sciences

Protocatechuic Aldehyde Inhibits Lipopolysaccharide-induced Human Umbilical Vein Endothelial Cell Apoptosis via Regulation of Caspase-3

(2012) Ya-Ling Xing et al.   PHYTOTHERAPY RESEARCH

Protocatechuic Aldehyde Protects against Experimental Sepsis In Vitro and In Vivo

(2011) Yong Xu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

A new regulation of IL-6 production in adult cardiomyocytes by β-adrenergic and IL-1β receptors and induction of cellular hypertrophy by IL-6 trans-signalling

(2010) Nicolas Szabo-Fresnais et al.   CELLULAR SIGNALLING

Differential Regulation of Proteasome Function in Isoproterenol-Induced Cardiac Hypertrophy

(2010) Oliver Drews et al.   CIRCULATION RESEARCH

Multifarious molecular signaling cascades of cardiac hypertrophy: Can the muddy waters be cleared?☆

(2010) Pitchai Balakumar et al.   PHARMACOLOGICAL RESEARCH

Molecular targets and regulators of cardiac hypertrophy

(2009) Agrawal Rohini et al.   PHARMACOLOGICAL RESEARCH

Antitumor and antioxidant activity of protocatechualdehyde produced from Streptomyces lincolnensis M-20

(2008) Kyoung-Ja Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Plasma and Urinary Tanshinol from Salvia miltiorrhiza (Danshen) Can Be Used as Pharmacokinetic Markers for Cardiotonic Pills, a Cardiovascular Herbal Medicine

(2008) T. Lu et al.   DRUG METABOLISM AND DISPOSITION