Do β-adrenoceptor agonists induce homologous or heterologous desensitization in rat urinary bladder?

In vitro and in vivo pharmacological profile of the selective β3-adrenoceptor agonist mirabegron in rats

(2013) Toshiki Hatanaka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Functional investigation of β-adrenoceptors in human isolated detrusor focusing on the novel selective β3-adrenoceptor agonist KUC-7322

(2013) Yasuhiko Igawa et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Decrease in heart adrenoceptor gene expression and receptor number as compensatory tool for preserved heart function and biological rhythm in M2 KO animals

(2013) Jan Benes et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Cross-regulation between cardiac muscarinic acetylcholine receptors and β-adrenoceptors: lessons for use of knock-out mice

(2013) Stefan Dhein et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pharmacological profile of β3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndrome

(2013) Yasuhiko Igawa et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A door opener for future research: agonist-induced β3-adrenoceptor desensitization in HEK cells but not CHO cells

(2013) Roland Seifert   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Agonist-induced desensitization of human β3-adrenoceptors expressed in human embryonic kidney cells

(2013) Martina B. Michel-Reher et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling

(2013) Robert A. Ngala et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

β2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle—ligand-directed signalling or a reflection of system complexity?

(2013) Bronwyn A. Evans et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pharmacological profile of the selective β3-adrenoceptor agonist mirabegron in cynomolgus monkeys

(2013) Toshiki Hatanaka et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Autonomic nervous control of the urinary bladder

(2012) P. Ochodnicky et al.   Acta Physiologica

Fenoterol functionally activates the β3-adrenoceptor in human urinary bladder, comparison with rat and mouse: Implications for drug discovery

(2012) Stefano Palea et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Multicenter, Double-blind, Randomized, Placebo-controlled Trial of the β3-Adrenoceptor Agonist Solabegron for Overactive Bladder

(2012) Eliot H. Ohlstein et al.   EUROPEAN UROLOGY

Randomized Double-blind, Active-controlled Phase 3 Study to Assess 12-Month Safety and Efficacy of Mirabegron, a β3-Adrenoceptor Agonist, in Overactive Bladder

(2012) Christopher R. Chapple et al.   EUROPEAN UROLOGY

Efficacy and Tolerability of Mirabegron, a β3-Adrenoceptor Agonist, in Patients with Overactive Bladder: Results from a Randomised European–Australian Phase 3 Trial

(2012) Vik Khullar et al.   EUROPEAN UROLOGY

Results of a Randomized Phase III Trial of Mirabegron in Patients with Overactive Bladder

(2012) Victor W. Nitti et al.   JOURNAL OF UROLOGY

Bladder selectivity of the novel β3-agonist ritobegron (KUC-7483) explored by in vitro and in vivo studies in the rat

(2012) Itaru Maruyama et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Prevalence of Clinically Meaningful Overactive Bladder: Bother and Quality of Life Results from the Population-Based FINNO Study

(2011) Camille P. Vaughan et al.   EUROPEAN UROLOGY

Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation

(2011) Lambertus P. W. Witte et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

β-Adrenoceptor agonist effects in experimental models of bladder dysfunction

(2011) Martin C. Michel et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacological Effect of TRK-380, a Novel Selective Human β3-Adrenoceptor Agonist, on Mammalian Detrusor Strips

(2011) Sayoko Kanie et al.   UROLOGY

Human Urinary Bladder Strip Relaxation by the β-Adrenoceptor Agonist Isoprenaline: Methodological Considerations and Effects of Gender and Age

(2011) Tim Schneider et al.   Frontiers in Pharmacology

Ligand-directed signalling at β-adrenoceptors

(2010) Bronwyn A. Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors

(2010) Jillian G Baker   BRITISH JOURNAL OF PHARMACOLOGY

Lack of evidence that nebivolol is a β3-adrenoceptor agonist

(2010) Elfaridah P. Frazier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antimuscarinic Mechanisms and the Overactive Detrusor: An Update

(2010) Karl-Erik Andersson   EUROPEAN UROLOGY

Predictors of discontinuing overactive bladder medications

(2009) Linda Brubaker et al.   BJU INTERNATIONAL

Patient-reported reasons for discontinuing overactive bladder medication

(2009) Joshua S. Benner et al.   BJU INTERNATIONAL

Do gene polymorphisms alone or in combination affect the function of human β3-adrenoceptors?

(2009) Wim Vrydag et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of pre-contraction on β-adrenoceptor-mediated relaxation of rat urinary bladder

(2009) Martin Christian Michel et al.   WORLD JOURNAL OF UROLOGY

Effects of a novel β3-adrenoceptor agonist, AJ-9677, on relaxation of the detrusor muscle: An in vitro study

(2008) Atsushi Otsuka et al.   INTERNATIONAL JOURNAL OF UROLOGY

Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma

(2008) Raymond B. Penn   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The effect of bladder outlet obstruction on α1- and β-adrenoceptor expression and function

(2008) Maurits M. Barendrecht et al.   NEUROUROLOGY AND URODYNAMICS

Physiological and pathological regulation of the autonomic control of urinary bladder contractility

(2007) Martin C. Michel et al.   PHARMACOLOGY & THERAPEUTICS