A novel inhibitory mechanism of nitrogen-containing bisphosphonate on the activity of Cl− extrusion in osteoclasts

TheArabidopsiscentral vacuole as an expression system for intracellular transporters: functional characterization of the Cl−/H+exchanger CLC-7

(2012) Alex Costa et al.   JOURNAL OF PHYSIOLOGY-LONDON

ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

(2011) Lilia Leisle et al.   EMBO JOURNAL

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

(2010) David E. Hughes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates

(2010) A.M. Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Antibodies against ClC7 inhibit extracellular acidification-induced Cl− currents and bone resorption activity in mouse osteoclasts

(2010) Kimiko Ohgi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Characteristics of ClC7 Cl− channels and their inhibition in mutant (G215R) associated with autosomal dominant osteopetrosis type II in native osteoclasts and hClcn7 gene-expressing cells

(2009) Hiroshi Kajiya et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Simvastatin inhibits acidic extracellular pH-activated, outward rectifying chloride currents in RAW264.7 monocytic-macrophage and human peripheral monocytes

(2008) Cheng-yao Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY