Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1

Expression of Mutant BMPR-II in Pulmonary Endothelial Cells Promotes Apoptosis and a Release of Factors that Stimulate Proliferation of Pulmonary Arterial Smooth Muscle Cells

(2014) Xudong Yang et al.   Pulmonary Circulation

Heme Oxygenase-1 in Lung Disease

(2012) Chintan M. Raval et al.   CURRENT DRUG TARGETS

Carbon monoxide as an endogenous vascular modulator

(2011) Charles W. Leffler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Simvastatin protects against the development of monocrotaline-induced pulmonary hypertension in rats via a heme oxygenase-1–dependent pathway

(2011) Wei-hua Zhang et al.   EXPERIMENTAL LUNG RESEARCH

Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension

(2011) Ling Chen et al.   HYPERTENSION

Caffeic Acid Phenethyl Ester Inhibits PDGF-Induced Proliferation of Vascular Smooth Muscle Cells via Activation of p38 MAPK, HIF-1α, and Heme Oxygenase-1

(2011) Thomas U. Roos et al.   JOURNAL OF NATURAL PRODUCTS

Altered Gene Expression in Pulmonary Tissue of Tryptophan Hydroxylase-1 Knockout Mice: Implications for Pulmonary Arterial Hypertension

(2011) Richard B. Rothman et al.   PLoS One

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts

(2011) Miguel Copaja et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Drug Treatment of Hyperlipidaemia

(2010) Peter P. Toth   DRUGS

Potent anti-ischaemic effects of statins in chronic stable angina: incremental benefit beyond lipid lowering?

(2010) J. E. Deanfield et al.   EUROPEAN HEART JOURNAL

Simvastatin-dependent up-regulation of heme oxygenase-1 via mRNA stabilization in human endothelial cells

(2010) Urte Hinkelmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Heme oxygenase-1/p21WAF1 mediates peroxisome proliferator-activated receptor-γ signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells

(2010) Manxiang Li et al.   FEBS Journal

Inhibitory Effects of Simvastatin on Platelet-derived Growth Factor Signaling in Pulmonary Artery Smooth Muscle Cells From Patients With Idiopathic Pulmonary Arterial Hypertension

(2010) Tetsuya Ikeda et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12 064 survivors of myocardial infarction: a double-blind randomised trial

(2010)   LANCET

Heme Oxygenase-1 Modulates Mesangial Cell Proliferation by P21Waf1Upregulation

(2010) Dileep Kumar et al.   RENAL FAILURE

Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension

(2010) Olin D. Liang et al.   STEM CELLS

Inhibition of cGMP phosphodiesterase 5 suppresses serotonin signalling in pulmonary artery smooth muscles cells

(2009) Manxiang Li et al.   PHARMACOLOGICAL RESEARCH

Pulmonary Vascular Involvement in COPD

(2008) Víctor I. Peinado et al.   CHEST

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

(2008) Georg Hansmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme Oxygenase-1 Inhibits the Proliferation of Pancreatic Stellate Cells by Repression of the Extracellular Signal-Regulated Kinase1/2 Pathway

(2008) C. I. Schwer et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS