Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing

Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site

(2013) D. J. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of EF-G-Ribosome Complexes Trapped in Intermediate States of Translocation

(2013) J. Zhou et al.   SCIENCE

Link of NTR-Mediated Spliceosome Disassembly with DEAH-Box ATPases Prp2, Prp16, and Prp22

(2012) Hsin-Chou Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

The Interaction of Prp2 with a Defined Region of the Intron Is Required for the First Splicing Reaction

(2012) H.-L. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS

(2012) T. Ohrt et al.   RNA

The ribosome as a molecular machine: the mechanism of tRNA–mRNA movement in translocation

(2011) Marina V. Rodnina et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Probing cellular protein complexes using single-molecule pull-down

(2011) Ankur Jain et al.   NATURE

Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity

(2011) H. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ordered and Dynamic Assembly of Single Spliceosomes

(2011) A. A. Hoskins et al.   SCIENCE

Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome

(2010) Joachim Frank et al.   Annual Review of Biochemistry

Monitoring multiple distances within a single molecule using switchable FRET

(2010) Stephan Uphoff et al.   NATURE METHODS

Conformational dynamics of single pre-mRNA molecules during in vitro splicing

(2010) John Abelson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps

(2010) C.-K. Tseng et al.   RNA

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

(2010) R. M. Lardelli et al.   RNA

RNA helicases at work: binding and rearranging

(2010) Eckhard Jankowsky   TRENDS IN BIOCHEMICAL SCIENCES

How Does a Scanning Ribosomal Particle Move along the 5′-Untranslated Region of Eukaryotic mRNA? Brownian Ratchet Model

(2009) Alexander S. Spirin   BIOCHEMISTRY

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Cwc25 Is a Novel Splicing Factor Required after Prp2 and Yju2 To Facilitate the First Catalytic Reaction

(2009) Y.-F. Chiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

(2009) Zbigniew Warkocki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single VS Ribozyme Molecules Reveal Dynamic and Hierarchical Folding Toward Catalysis

(2008) Miguel J.B. Pereira et al.   JOURNAL OF MOLECULAR BIOLOGY

A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

(2008) Beate Schwer   MOLECULAR CELL

A rugged free energy landscape separates multiple functional RNA folds throughout denaturation

(2008) Mark A. Ditzler et al.   NUCLEIC ACIDS RESEARCH