Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 16, Issue 3, Pages 343-344Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.1563
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Funding
- Damon Runyon Cancer Research Foundation [DRG-1863-05, DRG-1844-04]
- Howard Hughes Medical Institute
- US National Institutes of Health [K99 GM084076-01]
- W. M. Keck Foundation
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Riboswitches are mRNA domains that bind metabolites and modulate gene expression in cis. We report cocrystal structures of a remarkably compact riboswitch (34 nucleotides suffice for ligand recognition) from Bacillus subtilis that is selective for the essential nucleobase preQ1 (7-aminomethyl-7-deazaguanine). The structures reveal a previously unrecognized pseudoknot fold and suggest a conserved gene-regulatory mechanism whereby ligand binding promotes sequestration of an RNA segment that otherwise assembles into a transcriptional antiterminator. (c) 2009 Nature America, Inc. All rights reserved.
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