Article
Medicine, General & Internal
Agnieszka Lewinska, Piotr Palczewski, Krzysztof Pilat, Andrzej Cieszanowski, Witold Rongies
Summary: This study aimed to investigate the feasibility of using an MRI-based semi-quantitative system to evaluate structural changes in the hip joint of patients with hip OA undergoing a long-term physiotherapy program. The results showed that the system was reliable for evaluating hip abnormalities, but had limited value in detecting significant changes over a 12-month period of physiotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Patrick Haubruck, Raban Heller, Carina L. Blaker, Elizabeth C. Clarke, Susan M. Smith, Daniel Burkhardt, Yolanda Liu, Shihani Stoner, Sanaa Zaki, Cindy C. Shu, Christopher B. Little
Summary: A single slide for evaluating diverse histopathological changes in different joint tissues and disease stages can reduce scoring time and maintain sensitivity and specificity of the analysis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Veterinary Sciences
Siobhan S. Rickert, Philip H. Kass, Frank J. M. Verstraete
Summary: The prevalence of temporomandibular joint osteoarthritis (TMJ-OA) varied across different species, with male individuals being more affected in walrus, North American brown bear, polar bear, American black bear, and California mountain lion. Adult specimens were more affected by TMJ-OA than young adults in harbor seal, fur seal, walrus, and kit fox. Only three species, the harbor seal, northern fur seal, and polar bear, showed a significant increase in TMJ-OA prevalence when their teeth had attrition and abrasion.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ningning Zhang, Sheng Yang, Anne-Fleur Zwagemaker, Aihua Huo, Ying-Jia Li, Fang Zhou, Pamela Hilliard, Sandra Squire, Vanessa Bouskill, Arun Mohanta, Alex Zhou, Jose Jarrin, Runhui Wu, Jing Sun, Brian Luke, Rahim Moineddin, Victor S. Blanchette, Yun Peng, Andrea S. Doria
Summary: Color Doppler ultrasound is valuable in evaluating reactive synovitis in joints of subjects with inherited bleeding disorders, but shows limited correlation with grayscale ultrasound findings, indicating certain limitations.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brendan L. Eck, Mingrui Yang, John J. Elias, Carl S. Winalski, Faysal Altahawi, Naveen Subhas, Xiaojuan Li
Summary: Magnetic resonance imaging (MRI) is a valuable tool for evaluating musculoskeletal disease by providing image contrasts sensitive to tissue composition and microstructure. Quantitative MRI (qMRI) offers objective metrics that go beyond qualitative evaluation, supporting disease characterization, monitoring, and therapy response. This review summarizes musculoskeletal qMRI techniques, focusing on osteoarthritis evaluation.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Orthopedics
L. E. Watkins, B. Haddock, J. W. MacKay, J. Baker, S. D. Uhlrich, V. Mazzoli, G. E. Gold, F. Kogan
Summary: This study used [18F]sodium fluoride PET-MRI to assess the acute joint response to exercise in knee osteoarthritis (OA). Regional differences in the bone metabolic response to exercise were found, and areas of large changes in metabolic bone response may represent whole-joint dysfunction.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Walter P. Maksymowych, Andrew McReynolds, Susanne J. Pedersen, Ulrich Weber, Joel Paschke, Stephanie Wichuk, Jacob L. Jaremko, Robert G. Lambert
Summary: The revised KIMRISS method showed a significant increase in quantification of BML and synovitis-effusion compared to the established MOAKS method. KIMRISS achieved more frequently pre-specified targets for acceptable reliability, indicating its potential for progression to discrimination assessment according to OFISA criteria.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boya Li, Zikang Guo, Jin Qu, Ying Zhan, Zhiwei Shen, Xinwei Lei
Summary: This study explored the different involvement patterns of the knee synovio-entheseal complex (SEC) on MRI in patients with spondyloarthritis (SPA), rheumatoid arthritis (RA), and osteoarthritis (OA). The results showed that SEC involvement patterns differed between the three groups, which can be used for differential diagnosis of different diseases and should be comprehensively evaluated in clinical practice.
EUROPEAN RADIOLOGY
(2023)
Article
Orthopedics
Susan Mayes, Peter Smith, Debbie Stuart, Adam Semciw, Jill Cook
Summary: The research found that elite ballet dancers did not negatively affect cartilage health over 5 years, with most cartilage defects not progressing. Cartilage defects were related to low femoral neck-shaft angles, and the impact of cartilage defects on dance participation and pain levels was minimal.
CLINICAL JOURNAL OF SPORT MEDICINE
(2021)
Article
Multidisciplinary Sciences
Guijuan Cao, Shubo Gao, Bin Xiong
Summary: This study investigates and compares the values of 3.0 T MRI T1, T2, and T2* mapping quantification techniques in evaluating shoulder joint cartilage degeneration. The results show that the T1, T2, and T2* relaxation values are significantly correlated with the MRI-based grading of cartilage degeneration, and T2 mapping has the highest value among these techniques.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Takuhei Kozaki, Hiroshi Hashizume, Daisuke Nishiyama, Hiroshi Iwasaki, Shunji Tsutsui, Masanari Takami, Yasutsugu Yukawa, Akihito Minamide, Takaya Taniguchi, Keiji Nagata, Daisuke Fukui, Hidenobu Tamai, Ryo Taiji, Shizumasa Murata, Hiroyuki Oka, Hiroshi Yamada
Summary: This study found that spinal fixation surgery including SIJF is a predictor for radiographic progression of hip OA. Attention should be paid to hip joint lesions after adult spinal deformity surgery, especially those including SIJF.
EUROPEAN SPINE JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Akitoshi Inoue, Hiroaki Takahashi, Tatsuya Ibe, Hisashi Ishii, Yuhei Kurata, Yoshikazu Ishizuka, Yoichiro Hamamoto
Summary: This study compared the clinical usefulness of three different semiquantitative CT severity scoring systems for COVID-19 pneumonia. The results showed that all scoring systems demonstrated good interobserver agreement and substantial diagnostic performance for clinical severity. The interpretation time was significantly shorter in TSS and CCTS compared to CTSS. The scoring system showed the highest correlation with QDAR in CCTS, followed by TSS and CTSS. Therefore, CCTS appears to be the most appropriate CT scoring system for clinical practice.
EUROPEAN RADIOLOGY
(2022)
Review
Endocrinology & Metabolism
Benyi Yang, Xin Li, Chaoran Fu, Wenyi Cai, Bowen Meng, Yan Qu, Xiaoxing Kou, Qingbin Zhang
Summary: Osteoarthritis (OA) is a disabling disease with significant morbidity worldwide. Extracellular vesicles (EVs), such as exosomes and microvesicles, play an essential role in the progression and treatment of OA, regulating tissue homeostasis and cell-to-cell communication. Synovial fluid and synovium-derived EVs have been identified as potential biomarkers for OA, and mesenchymal stem cell-derived EVs have shown therapeutic effects. However, the different functions of EVs in knee joint and temporomandibular joint (TMJ) are not well understood.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
J. J. Heerey, R. Srinivasan, R. Agricola, A. Smith, J. L. Kemp, T. Pizzari, M. G. King, P. R. Lawrenson, M. J. Scholes, R. B. Souza, T. Link, S. Majumdar, K. M. Crossley
Summary: This study compared early hip osteoarthritis features on MRI in high-impact athletes with and without hip and/or groin pain. The findings suggest that hip and/or groin pain was associated with higher SHOMRI and labral scores, but early hip OA features were not associated with iHOT33 or HAGOS.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biology
Camilla Andersen, Stine Jacobsen, Marie Walters, Casper Lindegaard
Summary: Objective Osteoarthritis (OA) is a significant health issue in humans as well as horses. This study developed and validated a new scoring system for better differentiation of equine OA severity. The new scoring system provides a means to assess OA changes more accurately than the existing OARSI system.
BMC RESEARCH NOTES
(2022)
Article
Rheumatology
David J. Hunter, Leticia A. Deveza, Jamie E. Collins, Elena Losina, Jeffrey N. Katz, Michael C. Nevitt, John A. Lynch, Frank W. Roemer, Ali Guermazi, Michael A. Bowes, Erik B. Dam, Felix Eckstein, C. Kent Kwoh, Steve Hoffmann, Virginia B. Kraus
Summary: This study identifies the optimal combination of imaging and biochemical biomarkers for predicting knee osteoarthritis progression. These biomarkers have the potential to be used in future disease-modifying trials to select participants likely to experience progression of knee OA.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Frank W. Roemer, Ali Guermazi, Michael J. Hannon, Tomoko Fujii, Patrick Omoumi, David J. Hunter, Felix Eckstein, C. Kent Kwoh
Summary: Overweight and obese women have increased odds for developing radiographic OA, especially in the presence of inflammatory markers.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Orthopedics
Frank W. Roemer, Mohamed Jarraya, Jamie E. Collins, C. Kent Kwoh, Daichi Hayashi, David J. Hunter, Ali Guermazi
Summary: Structural phenotypic stratification can lead to more targeted trial populations and personalized treatment recommendations for patients. Radiologists can define the risk of progression in a joint based on the predominant phenotype present at different disease stages.
SKELETAL RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Frank W. Roemer
Article
Rheumatology
Wolfgang Wirth, Susanne Maschek, Anna Wisser, Ali Guermazi, David J. J. Hunter, C. Kent Kwoh, Michael C. C. Nevitt, Felix Eckstein, Frank W. W. Roemer
Summary: This study investigates the association between MRI-based articular pathologies and subsequent cartilage thickness loss. It found that cartilage damage, bone marrow lesions, medial meniscus extrusion or damage, as well as the severity of cartilage and meniscus damage are predictive of progression in the medial femorotibial compartment. MRI assessment can help select appropriate participants for clinical trials and identify those who do not require treatment.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Jean. W. W. Liew, Gabriela Rabasa, Michael LaValley, Jamie Collins, Joshua Stefanik, Frank. W. W. Roemer, Ali Guermazi, Cora. E. E. Lewis, Michael Nevitt, James Torner, David Felson
Summary: This study tested the performance of different MRI definitions for knee osteoarthritis and found that an MRI definition requiring cartilage damage and a small osteophyte, with or without bone marrow lesions or synovitis, had the best performance and simplicity for identifying radiographic and symptomatic knee osteoarthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Orthopedics
Frank Roemer, Susanne Maschek, Anna Wisser, Ali Guermazi, David Hunter, Felix Eckstein, Wolfgang Wirth
Summary: This study aimed to assess the association of worsening MRI semi-quantitative tissue features with concurrent change in quantitative cartilage thickness measurements. The study found that worsening cartilage damage, meniscal extrusion and damage, number of subregions affected by bone marrow lesions, maximal size of bone marrow lesions, and worsening effusion- and/or Hoffa synovitis were associated with increased cartilage loss.
Article
Sport Sciences
Kerry E. Costello, David T. Felson, S. Reza Jafarzadeh, Ali Guermazi, Frank W. Roemer, Neil A. Segal, Cora E. Lewis, Michael C. Nevitt, Cara L. Lewis, Vijaya B. Kolachalama, Deepak Kumar
Summary: This study developed a machine learning model that incorporates gait and physical activity to predict medial tibiofemoral cartilage worsening over 2 years in individuals without advanced knee osteoarthritis. The model showed good performance in predicting cartilage worsening and identified influential predictors in the outcome.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Orthopedics
S. Demehri, A. Kasaeian, F. W. Roemer, A. Guermazi
Summary: This narrative review summarizes original research on imaging in osteoarthritis (OA) published between April 1st 2021 and March 31st 2022. The study only considered English publications that were in vivo human studies. The review highlights the anatomical focus of research on the structures within the tibiofemoral, patellofemoral, hip, and hand joints, as well as the use of artificial intelligence in OA imaging.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
F. W. Roemer, K. Engelke, L. Li, J. -D. Laredo, A. Guermazi
Summary: This study aimed to investigate the diagnostic performance of routine MRI for assessing osteophytes in three knee compartments using CT as a reference standard. The study found that MRI underestimates the presence of osteophytes in all three compartments, and CT may be helpful in assessing small osteophytes, especially in early disease.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Shen Liu, Frank Roemer, Yong Ge, Edward J. Bedrick, Zong-Ming Li, Ali Guermazi, Leena Sharma, Charles Eaton, Marc C. Hochberg, David J. Hunter, Michael C. Nevitt, Wolfgang Wirth, C. Kent Kwoh, Xiaoxiao Sun
Summary: This study compares the evaluation metrics for deep learning methods developed using imbalanced imaging data in osteoarthritis studies. It found that the commonly used ROC curve is not sufficiently informative in the case of imbalanced data. Practical suggestions are provided for different degrees of data imbalance.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Rheumatology
Anna Dossing, Sabrina Mai Nielsen, Feline P. B. Kroon, Ida Maria Balsby, Simon Tarp, Margreet Kloppenburg, Lisa Stamp, Ida K. Haugen, Roy D. Altman, Marius Henriksen, Mikael Boesen, Henning Bliddal, Soren Berg, Robin Christensen
Summary: Oral NSAIDs and glucocorticoids are effective pharmacological interventions for hand osteoarthritis, while intra-articular therapies and topical NSAIDs are not superior to placebo.
Review
Rheumatology
Frank W. W. Roemer, Marc C. C. Hochberg, John A. A. Carrino, Andrew J. J. Kompel, Luis Diaz, Daichi Hayashi, Michel D. D. Crema, Ali Guermazi
Summary: Inhibitors of nerve growth factor (a-NGF) have shown efficacy in pain treatment for symptomatic osteoarthritis (OA). However, concerns about accelerated OA progression led to the suspension of a-NGF clinical trials in 2010. Trials were resumed in 2015 with improved safety measures based on imaging. In 2021, the FDA advisory committee voted against approving a-NGF compound tanezumab due to insufficient risk evaluation and mitigation strategy. Future trials will require strict eligibility criteria and close safety monitoring.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Sport Sciences
Stephanie Rose Filbay, Frank W. Roemer, L. Stefan Lohmander, Aleksandra Turkiewicz, Ewa M. Roos, Richard Frobell, Martin Englund
Summary: This study evaluated the natural course of ACL healing after ACL rupture within 5 years on MRI and compared the outcomes at 2 and 5 years based on healing status and treatment group. The results showed that ACL healing on MRI was associated with favorable outcomes, suggesting that the potential for spontaneous healing of the ACL may be greater than previously considered.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Rheumatology
Daichi Hayashi, Frank W. W. Roemer, Thomas Link, Xiaojuan Li, Feliks Kogan, Neil A. A. Segal, Patrick Omoumi, Ali Guermazi
Summary: The OA research community advocates for a shift from radiography-based criteria to MRI-based definition in OA clinical trials. Various evaluation tools and advanced technologies, including PET-MRI and AI, have been introduced in osteoarthritis imaging, aiming to improve precision and reproducibility in image interpretation.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
