Journal
NATURE REVIEWS NEPHROLOGY
Volume 5, Issue 11, Pages 612-614Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneph.2009.165
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In vitro evidence suggests that immune complex formation in IgA nephropathy is determined by the sugar content of the IgA1 hinge region. Absence of galactose residues in this region renders the IgA1 molecule immunogenic.
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