Review
Oncology
Benluvankar Varghese, Nunzio Del Gaudio, Gilda Cobellis, Lucia Altucci, Angela Nebbioso
Summary: Breast cancer is the second leading cause of cancer death in women, with genetic mutations and epigenetic modifications playing a critical role in its progression. The KDM4 enzymes are considered potential therapeutic targets for breast cancer, but the lack of selective inhibitors has hindered their entry into clinical trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Stephen J. Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Gottgens, John C. Marioni, Jennifer Nichols, Wolf Reik
Summary: This study provides a detailed analysis of the effects of perturbing DNA methylation on mouse organogenesis at a whole organism scale. It shows that both maintenance and de novo methyltransferase enzymes are essential for the formation of all major cell types during early organogenesis. Furthermore, the study reveals that DNA methyltransferases are required for silencing specific cell fates, while deletion of TET enzymes leads to lineage biases and a failure to demethylate distal regulatory elements.
Article
Cell Biology
Baoyu Chen, Yuwen Zhu, Junliang Chen, Yifei Feng, Yong Xu
Summary: This study reveals that differential TCL expression in malignant colorectal cancer cells is associated with histone H3K9 methylation, and the lysine demethylase KDM4B is essential for TCL transcription. KDM4B interacts with the transcription factor ERG1 to activate TCL transcription by facilitating the assembly of pre-initiation complex on the TCL promoter, ultimately influencing migration and invasion of CRC cells. Additionally, upregulation of KDM4B in advanced stage CRC specimens suggests it may serve as a potential therapeutic target for CRC intervention.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Eva Korytiakova, Ewelina Kaminska, Markus Mueller, Thomas Carell
Summary: The synthesis of a fluorinated fdC feeding probe allowed for the study of direct deformylation to F-dC, providing insights into the Tdg-independent removal process. The research demonstrated deformylation occurring in both stem cells and different somatic cell types. Additionally, active demethylation was investigated in a non-dividing neurogenin-inducible system of iPS cells differentiating into bipolar neurons.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Stephin Baby, Durgesh Gurukkala Valapil, Nagula Shankaraiah
Summary: Epigenetic enzyme-targeted therapy is a promising development in drug discovery, with histone deacetylases and DNA methyltransferases being investigated as druggable targets. Recently, histone methyltransferases and lysine demethylase inhibitors have become the focus of clinical trials as potential epi-drugs. KDM4 enzymes, part of the 2-OG-dependent oxygenases group, have attracted attention as novel targets in cancer therapy, with efforts being made to develop selective small molecule inhibitors.
DRUG DISCOVERY TODAY
(2021)
Review
Cell Biology
Anna Stein, Uwe Platzbecker, Michael Cross
Summary: This article examines the different mechanisms of action of azanucleosides in the treatment of myeloid neoplasia and their impact on stem cell lineage commitment and neoplastic progression. It also discusses the efficacy of azanucleoside treatment in neoplasias without mutations in epigenetic regulators. Furthermore, the article summarizes recent data on the role of azacytidine-sensitive RNA methylation in lineage commitment and cellular response to stress.
Article
Oncology
Behnia Akbari, Zahra Hosseini, Pardis Shahabinejad, Saba Ghassemi, Hamid Reza Mirzaei, Roddy S. O'Connor
Summary: This article focuses on the functional impairments of CAR T cells in tumor microenvironments, where tumor cell metabolism and nutrient competition affect the differentiation and function of CAR T cells' progeny. Metabolic intermediates shape the immune response by influencing epigenetic programs.
Article
Biochemistry & Molecular Biology
Xuelin Zhou, Mengwei Wei, Wenfeng Nie, Yue Xi, Li Peng, Qijie Zheng, Kai Tang, Viswanathan Satheesh, Yuhua Wang, Jinyan Luo, Xuan Du, Rui Liu, Zhenlin Yang, Honggui La, Yingli Zhong, Yu Yang, Jian-Kang Zhu, Jiamu Du, Mingguang Lei
Summary: This study reveals the molecular mechanism of AGDP3 in preventing gene silencing and DNA hypermethylation by binding to the H3K9me2 mark on DNA. The crystal structure analysis shows that AGDP3 anchors dimethylated H3K9 and unmodified H3K4 into different surface pockets, providing insights into its binding specificity.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Review
Cell Biology
Amir Hossein Mohseni, Sedigheh Taghinezhad-S, Vincenzo Casolaro, Zhongwei Lv, Dan Li
Summary: The microbiota plays a central role in regulating anti-tumor immune responses. Studies have shown a link between the microbiota and impaired T cell responses, tumor growth, and overall survival. The communication between T cells and the microbiota involves microbiota-derived metabolites. Bacterial translocation and tumor microbial communities also play a role in shaping the tumor microbiome.
CELL DEATH & DISEASE
(2023)
Review
Gastroenterology & Hepatology
Xing-Yu Liu, Chuan-Hao Guo, Zhi-Yuan Xi, Xin-Qi Xu, Qing-Yang Zhao, Li-Sha Li, Ying Wang
Summary: In pancreatic cancer research, histone methylation plays a crucial role, with writers and erasers potentially serving as therapeutic targets, while further research on reader domains is needed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emmy Xue Yun Tay, Kimberly Chia, Derrick Sek Tong Ong
Summary: Neural stem cells are crucial for normal brain development and are regulated by redox and epigenetic mechanisms. How this crosstalk impacts NSC activity remains poorly understood, as well as their contribution to brain ageing and neurodegenerative diseases. Therapeutic opportunities based on redox and epigenetic regulations are highlighted for rescuing NSC dysfunctions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Olimpia Mora-Janiszewska, Anna Faryniak-Zuzak, Dorota Darmochwal-Kolarz
Summary: Gestational diabetes mellitus (GDM) is a significant global problem that induces diabetogenic and obesogenic changes in an offspring's DNA through epigenetic mechanisms. Alterations in microbiota play a crucial role in this process. Identification of specific epigenetic marks may provide key solutions for personalized medicine. This manuscript summarizes available data on epigenetic changes among women with GDM and their offspring, in relation to microbiome alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sangpil Kim, Batakrishna Jana, Eun Min Go, Ji Eun Lee, Seongeon Jin, Eun-Koung An, Juyoung Hwang, Youjung Sim, Sehee Son, Dohyun Kim, Chaekyu Kim, Jun-O Jin, Sang Kyu Kwak, Ja-Hyoung Ryu
Summary: The study developed an intramitochondrial polymerization-induced self-assembly system for regulating the fate of cancer cells, inducing cell necroptosis by increasing ROS levels. This in situ polymerization system shows great potential for cancer treatment, including drug-resistant cancers.
Review
Cell & Tissue Engineering
Wenzhen Gao, Rong Li, Meilin Ye, Lanxin Zhang, Jiawen Zheng, Yuqing Yang, Xiaoyu Wei, Qing Zhao
Summary: The circadian clock is closely related to mesenchymal stem cell fate decisions in the skeletal system. It influences stem cell differentiation through hormone signals, regulation of transcription factors, interaction with epigenetic modifiers and non-coding RNAs, and even involvement in chromatin remodelling. The circadian regulation of stem cells is a promising candidate for health improvement and disease prevention.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Ana Sevilla, Dimitri Papatsenko, Amin R. Mazloom, Huilei Xu, Ana Vasileva, Richard D. Unwin, Gary LeRoy, Edward Y. Chen, Francine E. Garrett-Bakelman, Dung-Fang Lee, Benjamin Trinite, Ryan L. Webb, Zichen Wang, Jie Su, Julian Gingold, Ari Melnick, Benjamin A. Garcia, Anthony D. Whetton, Ben D. MacArthur, Avi Ma'ayan, Ihor R. Lemischka
Summary: The study shows that an interlocked feed-forward loop system involving Esrrb and Nanog plays a crucial role in regulating cell fate decisions in mouse embryonic stem cells. The maintenance of pluripotency is governed by the Oct4-Sox2 module, while the timing of differentiation is controlled by the Nanog-Esrrb module.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
