Review
Neurosciences
Hongzan Sun, Yong He, Heqi Cao
Summary: NSFC has been funding various research programs related to fMRI over the past two decades, with increasing support particularly in the General Program and Key Program. Leading research institutes in economically developed provinces and municipalities received the most support and established close collaboration relationships. Notable achievements in data analysis methods, brain connectomes, and computational platforms as well as their applications in brain disorders were reviewed.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Justine Robin, Richard Rau, Berkan Lafci, Aileen Schroeter, Michael Reiss, Xose-Luis Dean-Ben, Orcun Goksel, Daniel Razansky
Summary: The study found that fOA and fUS imaging have similar spatial resolution in capturing mouse brain responses to peripheral sensory stimulation, and can provide complementary hemodynamic readouts.
Review
Chemistry, Multidisciplinary
Zhichao Liu, Ying Zhu, Liming Zhang, Weiping Jiang, Yawei Liu, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou, Hongjie Zhang, Maili Liu, Chunhai Fan, Yang Tian
Summary: Analyzing the complex structures and functions of the brain is crucial for understanding physiological and pathological processes. However, subcellular structures of cells in the live brain and the concentrations, distributions, and interactions of functional molecules are still poorly understood.
SCIENCE CHINA-CHEMISTRY
(2023)
Review
Neurosciences
Thomas Deffieux, Charlie Demene, Mickael Tanter
Summary: In the past decade, sensitivity to slow blood flow motion has greatly improved with the introduction of ultrafast ultrasound imaging. In neuroscience, functional Ultrasound (fUS) has emerged as a new and promising tool for functional brain imaging, with potential applications in preclinical research and even in human clinical settings such as neonatal care and surgical procedures.
Article
Neurosciences
Brian E. Russ, Christopher Petkov, Sze Chai Kwok, Qi Zhu, Pascal Belin, Wim Vanduffel, Suliann Ben Hamed
Summary: Functional localizers are essential in non-human primate (NHP) imaging research, allowing for the definition of regions of interest, cross-study comparisons, and aggregation and meta-analyses of data. By sharing and implementing the same localizers, it is now possible to fully test their robustness, selectivity, and specificity through the PRIME-DE platform.
Article
Plant Sciences
Patrick Willems, Elvis Ndah, Veronique Jonckheere, Frank Van Breusegem, Petra Van Damme
Summary: Alternative translation initiation can shape multiple protein forms from a single gene. This study provides evidence for the existence of ~90 N-terminal proteoform pairs shaped by alternative translation initiation in Arabidopsis thaliana. The study also suggests that alternative translation initiation may serve as a common mechanism to supply protein copies in multiple cellular compartments.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, General & Internal
Xue Jiao, Ming Yuan, Qiuju Li, Yufei Huang, Miaomiao Ji, Jing Li, Shumin Yan, Hao Sun, Xinyu Wang, Zangyu Pan, Qianhui Ren, Dawei Wang, Guoyun Wang
Summary: This study used resting-state functional magnetic resonance imaging to investigate brain morphological alterations and regional dysfunctions in patients with adenomyosis-related pain. The results showed changes in multiple brain regions associated with pain as well as anxiety and depression symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Jisoo Han, Seonghoon Kim, Pyonggang Choi, Sungho Lee, Yongjae Jo, Eunsoo Kim, Myunghwan Choi
Summary: The study introduces an axially elongated Bessel beam in two-photon microscopy to address the focal shift issue during imaging of taste cells, enabling accurate imaging of physiological taste stimuli.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Neurosciences
Sadaf Soloukey, Arnaud J. P. E. Vincent, Marion Smits, Chris I. De Zeeuw, Sebastiaan K. E. Koekkoek, Clemens M. F. Dirven, Pieter Kruizinga
Summary: Real-time imaging of brain functionality during neurosurgical procedures, such as craniotomy, is important for safe navigation. Current practice relies on limited techniques like electrical stimulation, but experimental imaging techniques show potential to improve decision-making and safety. These techniques also enhance our understanding of human brain function.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Aaron Loh, David Gwun, Clement T. Chow, Alexandre Boutet, Jordy Tasserie, Jurgen Germann, Brendan Santyr, Gavin Elias, Kazuaki Yamamoto, Can Sarica, Artur Vetkas, Ajmal Zemmar, Radhika Madhavan, Alfonso Fasano, Andres M. Lozano
Summary: This article provides a comprehensive overview of studies that have used fMRI during active DBS to investigate its effects on various disorders. It discusses the stimulated brain regions, experimental designs, and insights gained from stimulation-induced fMRI responses.
Editorial Material
Chemistry, Physical
Michael A. Rowan
Summary: As spring arrives following winter, the editorial board has been improved and renewed. The new team includes the talented Early Career Advisory Board.
Article
Neurosciences
Michael Hutel, Michela Antonelli, Andrew Melbourne, Sebastien Ourselin
Summary: The General Linear Model used in task-fMRI has limitations in assuming neural activation is binary and in treating task-unrelated brain activity as noise. The Hemodynamic Matrix Factorization (HMF) method addresses these limitations by modeling both types of brain activity with the same convolution model.
Article
Neurosciences
Jose Maria Martinez de Paz, Emilie Mace
Summary: Functional ultrasound (fUS) is a hemodynamic-based neuroimaging technique with high spatiotemporal resolution, large field of view, and compatibility with behavior, making it well-suited for studying patterns of correlated activity between brain regions and brain-wide pathways associated with behavior. By combining fUS with optogenetics, its capabilities can be further enhanced, promising a significant impact in multi-modal studies.
Article
Engineering, Biomedical
Rohit Nayak, Jeyeon Lee, Siobhan Chantigian, Mostafa Fatemi, Su-Youne Chang, Azra Alizad
Summary: This study explored the feasibility of using functional ultrasound imaging to visualize cerebral activation associated with thalamic deep brain stimulation in rodents. The results showed that fUS imaging can identify DBS-evoked cerebral cortex activation, with low frequency stimulation having a higher activation effect on the primary motor cortex compared to higher frequencies. This preliminary study is an important step towards conducting real-time functional ultrasound imaging of DBS in awake and behaving animal models.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhenyue Chen, Quanyu Zhou, Xose Luis Dean-Ben, Irmak Gezginer, Ruiqing Ni, Michael Reiss, Shy Shoham, Daniel Razansky
Summary: Modern optical neuroimaging approaches have expanded our ability to study complex brain functions by developing a hybrid imaging platform that allows simultaneous observation of calcium and hemodynamic activation patterns. This research provides valuable insights into neurovascular and neurometabolic coupling mechanisms and related diseases.
Article
Neurosciences
Rubina Aktar, Madusha Peiris, Asma Fikree, Simon Eaton, Stamatiki Kritas, Stephen J. Kentish, Eduardo J. A. Araujo, Cristiano Bacarin, Amanda J. Page, Nicol C. Voermans, Qasim Aziz, L. Ashley Blackshaw
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
James K. Ruffle, Anya Patel, Vincent Giampietro, Matthew A. Howard, Gareth J. Sanger, Paul L. R. Andrews, Steven C. R. Williams, Qasim Aziz, Adam D. Farmer
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Gastroenterology & Hepatology
Fabienne G. M. Smeets, Daniel Keszthelyi, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Jose M. Conchillo, Joanna W. Kruimel, Jim Van Os, A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Review
Anesthesiology
Rolf-Detlef Treede, Winfried Rief, Antonia Barke, Qasim Aziz, Michael Bennett, Rafael Benoliel, Milton Cohen, Stefan Evers, Nanna B. Finnerup, Michael B. First, Maria Adele Giamberardino, Stein Kaasa, Beatrice Korwisi, Eva Kosek, Patricia Lavand'homme, Michael Nicholas, Serge Perrot, Joachim Scholz, Stephan Schug, Blair H. Smith, Peter Svensson, Johan W. S. Vlaeyen, Shuu-Jiun Wang
Biographical-Item
Gastroenterology & Hepatology
Qasim Aziz
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Gastroenterology & Hepatology
Kenichiro Nakagawa, Ken Hara, Asma Fikree, Shahab Siddiqi, Philip Woodland, Atsushi Masamune, Qasim Aziz, Daniel Sifrim, Etsuro Yazaki
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Medicine, Research & Experimental
David Gunn, Ron Fried, Rabia Lalani, Amanda Farrin, Ivana Holloway, Tom Morris, Catherine Olivier, Rachael Kearns, Maura Corsetti, Mark Scott, Adam Farmer, Anton Emmanuel, Peter Whorwell, Yan Yiannakou, David Sanders, John Mclaughlin, Kapil Kapur, Maria Eugenicos, Ayesha Akbar, Nigel Trudgill, Lesley Houghton, Phil G. Dinning, Alexander C. Ford, Qasim Aziz, Robin Spiller
Article
Gastroenterology & Hepatology
Adam D. Farmer, Ahmed Albusoda, Gehanjali Amarasinghe, James K. Ruffle, Heather E. Fitzke, Ruqaya Idrees, Ron Fried, Christina Brock, Qasim Aziz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Gastroenterology & Hepatology
Florencia Carbone, Nick Goelen, Asma Fikree, Qasim Aziz, Jan Tack
Summary: Functional dyspepsia (FD) often co-exists with joint hypermobility syndrome (JHS), characterized by decreased gastric accommodation and lower nutrient tolerance compared to FD patients with JHS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Tim Klaassen, Fabienne G. M. Smeets, Lisa Vork, Jan Tack, Nicholas J. Talley, Magnus Simren, Qasim Aziz, Alexander C. Ford, Joanna W. Kruimel, Jose M. Conchillo, Carsten Leue, Adrian A. M. Masclee, Daniel Keszthelyi
Summary: This study demonstrated the good validity and reliability of a novel ESM-based PROM for assessing gastrointestinal symptoms in FD patients. The novel PROM allows evaluation of individual symptom patterns and interactions between symptoms and environmental/contextual factors. ESM has the potential to increase patients' disease insight, provide tools for self-management, and improve shared decision making, aiding in the transition toward personalized health care for FD patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Ans Pauwels, Jan Tack, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study found that slow, deep breathing can reduce visceral pain intensity, which is not specific to the frequency of slow breathing and is not mediated by autonomic or emotional responses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: The study did not support the hypothesis that adding an inspiratory load to slow, deep breathing enhances its hypoalgesic effects. While pain intensity was slightly lower during SDB with load compared to normal-frequency controlled breathing, the difference was minimal. Heart rate variability was higher during SDB, but emotional responses were less favorable when using load.
Article
Anesthesiology
Abraham B. Beckers, Lukas van Oudenhove, Zsa Zsa R. M. Weerts, Heidi I. L. Jacobs, Nikos Priovoulos, Benedikt A. Poser, Dimo Ivanov, Ali Gholamrezaei, Qasim Aziz, Sigrid Elsenbruch, Ad A. M. Masclee, Daniel Keszthelyi
Summary: The study found that subjects with abdominal pain had more pronounced brain activation during infusion, while activation at the NTS level was independent of subjective pain ratings. These findings contribute to understanding the fundamental mechanism necessary for developing novel therapies aimed at correcting disturbances in visceral afferent pain processing.
Review
Gastroenterology & Hepatology
Christopher Roberts, Ahmed Albusoda, Adam D. Farmer, Qasim Aziz
Summary: This study aimed to determine whether individuals with irritable bowel syndrome (IBS) have lower pain thresholds compared to healthy individuals. The results showed that reduced rectal pain threshold is more common in IBS patients than in healthy controls. Further research is needed to understand the pathophysiological and therapeutic implications of rectal sensitivity in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Psychology, Biological
Ali Gholamrezaei, Ilse Van Diest, Qasim Aziz, Johan W. S. Vlaeyen, Lukas Van Oudenhove
Summary: This study compared four deep breathing techniques and found that loaded breathing was associated with better cardiovascular effects, while pursed-lips breathing had better emotional responses. The findings suggest that different deep breathing techniques may have varying impacts on physiological and emotional states.