Advances in the treatment of coeliac disease: an immunopathogenic perspective

The Duodenal Microbiota Composition of Adult Celiac Disease Patients Is Associated with the Clinical Manifestation of the Disease

(2013) Pirjo Wacklin et al.   INFLAMMATORY BOWEL DISEASES

Changed gluten immunity in celiac disease by Necator americanus provides new insights into autoimmunity

(2013) John Croese et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Exploratory, Randomized, Double-blind, Placebo-controlled Study on the Effects of Bifidobacterium infantis Natren Life Start Strain Super Strain in Active Celiac Disease

(2013) Edgardo Smecuol et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study

(2012) C. P. Kelly et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A Randomized, Double-Blind Study of Larazotide Acetate to Prevent the Activation of Celiac Disease During Gluten Challenge

(2012) Daniel A Leffler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Celiac Disease: Advances in Treatment via Gluten Modification

(2012) Samantha Stoven et al.   Clinical Gastroenterology and Hepatology

The Role of Corticosteroids in Celiac Disease

(2012) Melissa Latorre et al.   DIGESTIVE DISEASES AND SCIENCES

Interactions Among Secretory Immunoglobulin A, CD71, and Transglutaminase-2 Affect Permeability of Intestinal Epithelial Cells to Gliadin Peptides

(2012) Corinne Lebreton et al.   GASTROENTEROLOGY

Mucosal healing in inflammatory bowel diseases: a systematic review

(2012) Markus F Neurath et al.   GUT

Are Transglutaminase 2 Inhibitors Able to Reduce Gliadin-Induced Toxicity Related to Celiac Disease? A Proof-of-Concept Study

(2012) Tiina Rauhavirta et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-15 positively regulates IL-21 production in celiac disease mucosa

(2012) M Sarra et al.   Mucosal Immunology

Bifidobacterium longum CECT 7347 Modulates Immune Responses in a Gliadin-Induced Enteropathy Animal Model

(2012) José Moisés Laparra et al.   PLoS One

Regulation of the activities of the mammalian transglutaminase family of enzymes

(2012) Cornelius Klöck et al.   PROTEIN SCIENCE

Celiac disease: Management of persistent symptoms in patients on a gluten-free diet

(2012) David H Dewar   WORLD JOURNAL OF GASTROENTEROLOGY

Impaired Control of Effector T Cells by Regulatory T Cells: A Clue to Loss of Oral Tolerance and Autoimmunity in Celiac Disease?

(2011) Nadia Belhadj Hmida et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

(2011) T. Rauhavirta et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Safety, Tolerability, and Activity of ALV003: Results from Two Phase 1 Single, Escalating-Dose Clinical Trials

(2011) Matthew Siegel et al.   DIGESTIVE DISEASES AND SCIENCES

The Chemokine Receptor CCR9 Is Required for the T-Cell–Mediated Regulation of Chronic Ileitis in Mice

(2011) Joshua D. Wermers et al.   GASTROENTEROLOGY

Gut-Tropic T Cells That Express Integrin α4β7 and CCR9 Are Required for Induction of Oral Immune Tolerance in Mice

(2011) Barbara Cassani et al.   GASTROENTEROLOGY

The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues

(2011) Maud Pinier et al.   GASTROENTEROLOGY

Novel therapies for coeliac disease

(2011) L. M. Sollid et al.   JOURNAL OF INTERNAL MEDICINE

Effect of Hookworm Infection on Wheat Challenge in Celiac Disease – A Randomised Double-Blinded Placebo Controlled Trial

(2011) A. James Daveson et al.   PLoS One

CCL25/CCR9 Interactions Regulate Large Intestinal Inflammation in a Murine Model of Acute Colitis

(2011) Marc-Andre Wurbel et al.   PLoS One

Suppression of Inflammatory Immune Responses in Celiac Disease by Experimental Hookworm Infection

(2011) Henry J. McSorley et al.   PLoS One

A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects

(2011) Z. Simon-Vecsei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transglutaminase 2-targeted autoantibodies in celiac disease: Pathogenetic players in addition to diagnostic tools?

(2010) Katri Lindfors et al.   AUTOIMMUNITY REVIEWS

Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab

(2010) H. E. Mei et al.   BLOOD

Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture

(2010) K. Lindfors et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells

(2010) S. M. Stenman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Safety for Patients With Celiac Disease of Baked Goods Made of Wheat Flour Hydrolyzed During Food Processing

(2010) Luigi Greco et al.   Clinical Gastroenterology and Hepatology

Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library

(2010) Ulrike Jüse et al.   HUMAN IMMUNOLOGY

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis

(2010) Georgia Malamut et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine

(2010) M. Wigren et al.   JOURNAL OF INTERNAL MEDICINE

Gluten-free Sourdough Wheat Baked Goods Appear Safe for Young Celiac Patients: A Pilot Study

(2010) Raffaella Di Cagno et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease

(2010) J Huan et al.   Mucosal Immunology

Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

(2010) J. A. Tye-Din et al.   Science Translational Medicine

Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease

(2009) Satumarja M. Stenman et al.   ANNALS OF MEDICINE

The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo

(2009) Jason A. Tye-Din et al.   CLINICAL IMMUNOLOGY

Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin α4β7-positive T cells in blood

(2009) Antonio Di Sabatino et al.   HUMAN PATHOLOGY

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

(2009) A. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

(2008) Karen M. Lammers et al.   GASTROENTEROLOGY

Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium

(2008) Maud Pinier et al.   GASTROENTEROLOGY

In vitro induction of regulatory T cells by anti-CD3 antibody in humans

(2008) Michal Abraham et al.   JOURNAL OF AUTOIMMUNITY

Mucosal tissue transglutaminase expression in celiac disease

(2008) Vincenzo Villanacci et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease

(2008) M C Collado et al.   JOURNAL OF CLINICAL PATHOLOGY

Differentiation and homing of IgA-secreting cells

(2008) J R Mora et al.   Mucosal Immunology

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Non-Human Primate Model for Gluten Sensitivity

(2008) Michael T. Bethune et al.   PLoS One

Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with Celiac disease

(2007) Varsha V. Kapoerchan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Treatment of life-threatening type I refractory coeliac disease with long-term infliximab

(2007) G. Costantino et al.   DIGESTIVE AND LIVER DISEASE

Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids

(2007) Rodrigo J. Mora   INFLAMMATORY BOWEL DISEASES