Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Chemistry, Analytical
Shreya Singh Beniwal, Paula Lamo, Ajeet Kaushik, Dionisio Lorenzo Lorenzo-Villegas, Yuguang Liu, Arunsundar Mohanasundaram
Summary: Colorectal cancer is a prevalent and potentially fatal disease, and effective diagnostic strategies are needed. Microfluidic diagnostics offer non-invasive real-time monitoring of disease progression and treatment response. Advancements in microfluidic technology and integration with artificial intelligence hold promise for accurate, efficient, and personalized strategies to improve patient outcomes and transform cancer management.
Article
Gastroenterology & Hepatology
Ansgar Deibel, Lu Deng, Chih-Yuan Cheng, Michael Schlander, Tao Ran, Brian Lang, Niklas Krupka, Niko Beerenwinkel, Gerhard Rogler, Reiner Wiest, Amnon Sonnenberg, Jan Poleszczuk, Benjamin Misselwitz
Summary: The study aimed to identify the characteristics of highly efficient theoretical screening tests and evaluate the effectiveness and cost-effectiveness of available screening tests for colorectal cancer. The findings indicated that highly efficient theoretical screening tests have high sensitivity and patient adherence, while all available screening tests were effective and cost-efficient at expected adherence rates.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Environmental Sciences
Christopher J. Martyniuk, Ruben Martinez, Laia Navarro-Martin, Jorke H. Kamstra, Adam Schwendt, Stephane Reynaud, Lorraine Chalifour
Summary: Endocrine disrupting chemicals (EDCs) are widespread and can interfere with hormone signaling through diverse chemical-receptor interactions. Current testing efforts have focused on chemicals acting through EATS modalities, with less established tests for non-EATS modalities. There is a need for validated assays for non-EATS modalities to develop regulatory tools and protect environmental and human health.
ENVIRONMENTAL RESEARCH
(2022)
Article
Surgery
Casey J. Allen, Nathan Bloom, Michael Rothka, Pavan Rao, Patrick L. Wagner, David L. Bartlett, Katie Farah, Sricharan Chalikonda
Summary: This study aimed to determine the comprehensive, long-term cost implications of noninvasive screening modalities for colorectal cancer (CRC). The results showed that adopting FIT as the primary screening method can generate significant cost savings and carries significant value implications for a large population health system.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Review
Gastroenterology & Hepatology
Wen Liu, An-Rong Zeng, Han-Zhou Tang, Jin-Wei Qiang
Summary: CTC and MRC have relatively higher diagnostic value for diagnosing CRC, while PET/CT has higher diagnostic value in detecting local recurrence for patients with CRC.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marianna Nalli, Michela Puxeddu, Giuseppe La Regina, Stefano Gianni, Romano Silvestri
Summary: This review highlights promising new therapeutic agents for CRC patients, including tyrosine kinase inhibitors, BRAF and MEK inhibitors, TLR9 agonists, STAT3 inhibitors, and immune checkpoint blockers. Recent advances in these agents have shown potential benefits for CRC patients with unmet medical needs.
Editorial Material
Medicine, General & Internal
John M. M. Carethers
Summary: A 56-year-old man with no significant medical history declined screening colonoscopy in the past but now wants a less invasive test due to his father's death from colorectal cancer. What is the next course of action?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Oncology
Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh, Maryam Farzaneh
Summary: Colorectal cancer is the third leading cause of cancer death in the world. Recent studies have shown that long non-coding RNAs play important roles in colorectal cancer cells, and NEAT1 is a key factor involved in the development and progression of colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Selda Tekiner, Gulsen Ceyhun Peker, Mine Ceylan Dogan
Summary: This study evaluated the health beliefs of relatively young individuals in Turkey regarding colorectal cancer screening before the screening age, finding that attitudes towards preventive health measures are mainly associated with age, gender, education level, and marital status.
Review
Immunology
Eric Jou, Noe Rodriguez-Rodriguez, Andrew N. J. McKenzie
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and current immunotherapeutic interventions have limited effectiveness. Cytokines interleukin-25 (IL-25) and IL-33, expressed by barrier epithelial cells, play important roles in the intestinal immune responses and can influence tumorigenesis in CRC. IL-25 and IL-33 have different effects on different subtypes of CRC and can modulate various immune cell types and pathways, including angiogenesis, tumor stemness, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Cornelia S. Link-Rachner, Katja Sockel, Catharina Schuetz
Summary: This review summarizes the recent advances in the understanding of the pathophysiology of GvHD, clinical trials, and newly approved agents, with a special focus on skin involvement.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Krishna P. Sharma, Amy DeGroff, Annette E. Maxwell, Allison M. Cole, Ngoc Cam Escoffery, Peggy A. Hannon
Summary: Client reminders, provider assessment and feedback, and colorectal cancer screening champions were found to be associated with increased clinic-level colorectal cancer screening rates according to this study. The universal implementation of these strategies can substantially increase colorectal cancer screening rates in the U.S.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Review
Immunology
Shuang Peng, Jian Gao, Darko Stojkov, Shida Yousefi, Hans-Uwe Simon
Summary: Neutrophils, the most abundant innate immune cells in human blood, have been overlooked in terms of their mitochondria function. However, growing evidence shows that mitochondria play a crucial role in various aspects of neutrophil biology, from development to chemotaxis, effector function, and cell death. Mitochondria and their components can also be released by neutrophils to eliminate infection and shape immune response. This review highlights the importance of mitochondria in modulating neutrophil phenotype and function during infection and inflammation, and discusses the potential and challenges of exploiting mitochondria in neutrophils for disease treatment.
IMMUNOLOGICAL REVIEWS
(2023)