Article
Cell Biology
Ryuzaburo Yuki, Mari Hagino, Sachi Ueno, Takahisa Kuga, Youhei Saito, Yasunori Fukumoto, Noritaka Yamaguchi, Naoto Yamaguchi, Yuji Nakayama
Summary: v-Src alters the cytotoxicities of microtubule-targeting agents (MTAs) and polo-like kinase 1 (PLK1) inhibitor, but not DNA-damaging anticancer drugs. It induces mitotic slippage of MTAs-treated cells, leading to the generation of proliferating tetraploid cells. Treatment with Aurora kinase inhibitor strongly induces cell death in cells expressing v-Src.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Jaebeom Park, Minji Kang, Ahyoung Lim, Kyung-Jin Cho, Chong Hak Chae, Byumseok Koh, Hongjun Jeon
Summary: This study synthesizes various tirbanibulin derivatives and explores their structure-activity relationship, filling the gap in the current literature on tirbanibulin and its derivatives. The para fluorination on the benzylamine part shows promising outcomes in cellular potency and pharmacokinetics.
Review
Oncology
Huiyao Huang, Dawei Wu, Huilei Miao, Yu Tang, Chengcheng Liu, Hong Fang, Xinyu Meng, Shuhang Wang, Qi Zhu, Xin Wang, Jingting Du, Zhimin Yang, Ning Li, Binghe Xu, Jie He
Summary: This Policy Review compares the participation rates of China with the USA, EU, Japan, and South Korea in clinical trials for innovative anticancer drugs. The results show that China's participation rates are significantly lower than those of the other countries in both overall and synchronous participation. Despite an increase in participation over the past decade, China still lags behind the other regions, particularly in terms of synchronous participation and early participation rates.
Article
Pharmacology & Pharmacy
Zhiqiang Yang, Jiangtao Xie, Jiayu Fang, Minchao Lv, Min Yang, Zhouming Deng, Yuanlong Xie, Lin Cai
Summary: Nigericin shows promising anticancer effects in human osteosarcoma by inhibiting tumor cell proliferation, inducing apoptosis, and targeting the SRC/STAT3 signaling pathway. The drug also inhibits tumor migration and invasion, and shows potential for clinical application in osteosarcoma treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sumaira Javaid, Atia-tul-Wahab, Humaira Zafar, M. Iqbal Choudhary
Summary: Drug repositioning is an effective approach in drug discovery, and this study evaluated the modulation of p8 subunit activity in TFIIH complex by several drugs. Out of 60 drugs tested, 7 showed potential interactions with p8 subunit and thermal destabilization. Further investigation is needed to explore their potential as anticancer drugs.
BIOORGANIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Elena Catanzaro, Donatella Canistro, Valentina Pellicioni, Fabio Vivarelli, Carmela Fimognari
Summary: This review presents and critically discusses the chemistry and biosynthesis of allicin, its pharmacokinetic profile, its anticancer mechanisms and molecular targets, and its selectivity towards tumor cells. The research carried out so far reveals that allicin suppresses the growth of different types of tumors by targeting multiple signaling pathways associated with cancer development. Future research directions are outlined to further explore the potential of allicin as a natural product for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Polymer Science
Naushad Ahmad, Mohammad Rizwan Khan, Subramanian Palanisamy, Sonaimuthu Mohandoss
Summary: This study successfully developed chitosan nanoparticles encapsulated with cisplatin and 5-fluorouracil, which demonstrated antibacterial and anticancer activities. The nanoparticles were able to control and sustain the release of the drugs, and showed significant inhibitory effects on the growth of cancer cells.
Article
Chemistry, Multidisciplinary
Elisa Hernandez Becerra, Jennifer Quinchia, Cristina Castro, Jahir Orozco
Summary: Polymersomes are biomimetic cell membrane-like model structures that have gained attention for their biocompatibility, versatility, and tunable properties. They can encapsulate cargoes and be triggered to disassemble in response to stimuli, making them suitable for photodynamic therapy. This review explores the current advances and applications of light-responsive polymersomes in anticancer therapy.
Review
Biochemistry & Molecular Biology
Fatima Carvalho, Manuel Aureliano
Summary: This study analyzed the recent research on polyoxometalates as anticancer agents, focusing on their effects on the cell cycle. The findings showed that polyoxometalates can have diverse effects on the cell cycle, including protein expression, mitochondrial effects, ROS production, cell death, and cell viability. Comparison with clinically approved drugs revealed better results for polyoxometalates in many cases, suggesting their potential as alternative cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ghanshyam Teli, Rohit Pal, Lalmohan Maji, Gurubasavaraja Swamy Purawarga Matada, Sindhuja Sengupta
Summary: The pyrimidine and fused pyrimidine ring systems are important in inhibiting the c-Src kinase. Despite its association with cancer, the exploration of Src kinase by medicinal chemists is still limited, making it a niche pathway. This review focuses on the activation process of Src kinase, the chemistry of pyrimidine ring and its synthetic routes, as well as recent developments in c-Src kinase inhibitors containing pyrimidine and their biological activity, structure-activity relationship (SAR), and selectivity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Editorial Material
Optics
Jiazheng Qin, Mengjia Wang, Cheng-Wei Qiu
Summary: By controlling graphene, it has become easier to access and track exceptional points.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Elisa Abas, Diego Aguirre-Ramirez, Mariano Laguna, Laura Grasa
Summary: Newly synthesized dithiocarbamate cycloaurated complexes exhibit good antitumor properties with excellent in vitro antiproliferative activity and selectivity. They also show good antimicrobial activity against various bacteria and fungi.
Article
Environmental Sciences
Michal Tonski, Joanna Dolzonek, Piotr Stepnowski, Anna Bialk-Bielinska
Summary: Anticancer drugs are highly hazardous due to their genotoxic, carcinogenic and teratogenic mechanisms of action. The hydrolytic stability of commonly used anticancer drugs was investigated, with results showing that cyclophosphamide and ifosfamide were unstable while other compounds displayed high stability. Further experiments revealed that cyclophosphamide and ifosfamide would be quite persistent in terms of hydrolytic stability at environmentally relevant temperatures.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Marine & Freshwater Biology
Maikon Kelbert, Naionara Ariete Daronch, Camila Senna Pereira, Karina Cesca, Camila Michels, Hugo Moreira Soares
Summary: The inhibitory effect of the anticancer drug doxorubicin on biogas production was evaluated. It was found that the inhibitory effect at higher concentrations is reversible and that the drug can be rapidly sorbed by biomass, potentially contributing to the inhibition.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
Maikon Kelbert, Camila Senna Pereira, Naionara Ariete Daronch, Karina Cesca, Camila Michels, Debora de Oliveira, Hugo Moreira Soares
Summary: This study investigated the degradation of an anticancer drug by laccase for the first time, demonstrating great potential in removing these hazardous substances from effluents. The enzymatic degradation of doxorubicin showed good affinity and effectiveness under specific conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2018)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
Editorial Material
Genetics & Heredity
Darren J. Burgess
NATURE REVIEWS GENETICS
(2019)
