Reproducibility of research and preclinical validation: problems and solutions

Announcement: Reducing our irreproducibility

(2013)   NATURE

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Beware the creeping cracks of bias

(2012) Daniel Sarewitz   NATURE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Biomarker studies: a call for a comprehensive biomarker study registry

(2011) Fabrice Andre et al.   Nature Reviews Clinical Oncology

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

The relationship between health and GDP in OECD countries in the very long run

(2010) Robyn Swift   HEALTH ECONOMICS

Quantity and Quality in Medical Research

(2010) Iyad N. Daher et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Repeatability of published microarray gene expression analyses

(2009) John P A Ioannidis et al.   NATURE GENETICS

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

How Many Scientists Fabricate and Falsify Research? A Systematic Review and Meta-Analysis of Survey Data

(2009) Daniele Fanelli   PLoS One