Article
Dermatology
Christos C. Zouboulis, Mankul Goyal, Angel S. Byrd
Summary: Hidradenitis suppurativa in South-East Asia and East Asia exhibits distinct clinical, environmental, physiological, and likely genetic differences compared to the Western region, with a male predominance, varying affected areas, and common metabolic comorbidities. Further studies on Asian ethnic subgroups are warranted.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Immunology
Tomonori Kadowaki, Saori Kadowaki, Hidenori Ohnishi
Summary: HA20, caused by a mutation in the TNFAIP3 gene, can present as an early onset autoinflammatory disease resembling Behcet's disease. Patients in East Asia with HA20 more frequently develop recurrent fever but have lower rates of typical BD symptoms. Treatment for severe HA20 in East Asia primarily involves anti-TNF-alpha agents.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Health Care Sciences & Services
Christo Kole, Nikolaos Charalampakis, Stratigoula Sakellariou, George Papaxoinis, Konstantinos G. Apostolou, Nikolaos Machairas, Ioannis S. Papanikolaou, Dimitrios Schizas
Summary: Gastric cancer is a common malignancy, with the majority being sporadic and only a small percentage being hereditary. Hereditary diffuse gastric cancer (HDGC) is a rare early-onset disease primarily caused by genetic alterations in the E-cadherin gene and beta-catenin gene. This study provides an overview of the molecular basis of HDGC, outlines essential elements of genetic counseling and surveillance, and offers a practical summary of current guidelines for the clinical management and treatment of high-risk individuals and patients with early-stage disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Changzhen Lei, Daojun Gong, Bo Zhuang, Zhiwei Zhang
Summary: The gastric microbiota and its metabolites are associated with the development of gastric cancer. Metabolomics provides an advanced method for analyzing microbiota-derived metabolites, accelerating our understanding of the metabolic interactions between gastric microbiota and gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Carla Pereira, Ji-Hyeon Park, Sofia Campelos, Irene Gullo, Carolina Lemos, Leslie Solorzano, Diana Martins, Gilza Goncalves, Dina Leitao, Hyuk-Joon Lee, Seong-Ho Kong, Ana Andre, Clara Borges, Daniela Almeida, Carolina Walbhy, Raquel Almeida, Woo Ho Kim, Fatima Carneiro, Han-Kwang Yang, Gabriela M. Almeida, Carla Oliveira
Summary: Surgical resection with lymphadenectomy and perioperative chemotherapy is the mainstay treatment for gastric cancer patients. The study found specific immunophenotypic profiles in chemo-naive patients from Portugal and South Korea, impacting overall survival and aggressiveness of the disease. The discrepancy in survival rates between Western and Eastern regions may be due to different immunophenotypic profiles and clinical factors.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Geosciences, Multidisciplinary
Jinfang Yin, Xudong Liang, Yanxin Xie, Feng Li, Kaixi Hu, Lijuan Cao, Feng Chen, Haibo Zou, Feng Zhu, Xin Sun, Jianjun Xu, Geli Wang, Ying Zhao, Juanjuan Liu
Summary: This study developed the East Asia Reanalysis System (EARS) using the WRF model and GSI data assimilation system, forced by ECMWF global reanalysis ERA-Interim data. Surface observations were assimilated using the FDDA scheme, while upper observations were assimilated using 3D-VAR mode. The evaluation showed substantial improvements in EARS compared to ERA-Interim reanalysis fields over East Asia.
EARTH SYSTEM SCIENCE DATA
(2023)
Review
Oncology
Chichao Xia, Sile Li, Teng Long, Zigui Chen, Paul K. S. Chan, Siaw Shi Boon
Summary: This review provides an updated overview of cancer-causing HPV genotypes in East, Southeast, and South Asia, highlighting differences in detection and treatment methods compared to other regions. The article also points out the lack of study in certain areas and the challenges faced in HPV research.
Article
Oncology
Kuiwu Ren, Chunlong Liu, Ziqiang He, Panpan Wu, Jian Zhang, Rui Yang, Tao Cui, Kun Song, Di Cheng, Kui He, Jiangtao Yu
Summary: This study systematically examined the epidemiological characteristics of pancreatic cancer in East Asia, and found that the mortality rate of pancreatic cancer in males is decreasing in Japan and Korea, while increasing in China, Mongolia, and North Korea. The risk factors for pancreatic cancer in East Asia remained stable between 2010 and 2019. By 2030, it is projected that the mortality rate of pancreatic cancer in Chinese males will exceed that of Japan and Korea.
Review
Gastroenterology & Hepatology
Xuefeng Luo, Virginia Hernandez-Gea
Summary: Gastro-oesophageal varices are major clinical manifestations of cirrhosis and portal hypertension. There are various treatment options available for managing them, but the optimal strategy remains controversial.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Myung-Il Jung, Seok-Woo Son, Hyemi Kim, Deliang Chen
Summary: Understanding air pollution in East Asia is crucial due to its high population density and severe winter pollution. This study reveals that the day-to-day variability of air pollution in East Asia during winter is influenced by the Madden-Julian Oscillation (MJO), a dominant subseasonal variability in the tropics. The concentration of PM10 significantly increases during suppressed tropical convections over the Indian Ocean (MJO phase 5-6) and decreases during enhanced convections (MJO phase 1-2).
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Akane O. Abbasi, Xiaolu Tang, Nancy L. Harris, Elizabeth D. Goldman, Javier G. P. Gamarra, Martin Herold, Hyun Seok Kim, Weixue Luo, Carlos Alberto Silva, Nadezhda M. Tchebakova, Ankita Mitra, Yelena Finegold, Mohammad Reza Jahanshahi, Cesar Ivan Alvarez, Tae Kyung Kim, Daun Ryu, Jingjing Liang
Summary: Planted forests in East Asia, which account for approximately 36% of global planted forest area, play a critical role in climate change mitigation and timber/non-timber production. However, there is limited information available on the geographic distribution and tree species composition of these planted forests. This study presents the first spatial database of planted forests in East Asia, based on extensive data collection and modeling. The maps generated in this study provide valuable information for understanding the role of planted forests in climate change mitigation and guiding forest conservation and management decisions.
Article
Public, Environmental & Occupational Health
Xuanke Ji, Gui He, Kunyan Wang, Yuehua Zhang, Jingjing Yin, Kaijuan Wang
Summary: H. pylori infection causes a significant burden of gastric cancer in Asia, especially in countries with high incidence and mortality rates.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Meteorology & Atmospheric Sciences
Yujoo Jeong, Si-Wan Kim, Jeongyeon Kim, Daegeun Shin, Jeongeun Kim, Jae-Heung Park, Soon-Il An
Summary: This study investigates the correlation between tropospheric ozone in East Asia and the El Nino Southern Oscillation (ENSO). The results show a significant correlation between tropospheric ozone and the wintertime Nino 3.4 index during El Nino/La Nina developing summer and decaying spring, with a correlation coefficient of up to 0.9. Ozone concentrations in China and the Korean Peninsula are higher during El Nino developing summer compared to La Nina, while the opposite occurs in El Nino/La Nina decaying spring. These findings are supported by both model simulations and ozone observations.
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
(2023)
Article
Meteorology & Atmospheric Sciences
Chia-Chi Wang, Huang-Hsiung Hsu, Ying-Ting Chen
Summary: An objective front detection method was used to evaluate climate model performance in simulating front frequency and to predict future seasonal front activities in East Asia. The results suggest decreases in winter fronts and increases in frontal precipitation in the South China Sea and tropical western Pacific, while spring activities may vary with more fronts in central China, the Korean Peninsula, and Japan.
JOURNAL OF CLIMATE
(2021)
Article
Plant Sciences
Yan Wu, Dawei Tao, Xiujie Wu, Wu Liu, Yanjun Cai
Summary: Reconstructing the diet of early modern humans provides important insights into human origins and evolution. This study analyzed starch grains in dental calculus from early modern humans in Fuyan Cave, revealing that their diet consisted of acorns, roots, tubers, grass seeds, and other unidentified plants. The study also suggests that acorns played a significant role in their subsistence strategies and that there may have been a long-standing tradition of using these plants in Late Pleistocene China.
FRONTIERS IN PLANT SCIENCE
(2022)