Article
Cardiac & Cardiovascular Systems
Yuki Ikeda, Shunsuke Ishii, Kenji Maemura, Takumi Oki, Mayu Yazaki, Teppei Fujita, Takeru Nabeta, Emi Maekawa, Toshimi Koitabashi, Junya Ako
Summary: In hospitalized patients with acute heart failure, there is a strong correlation between the severity of intestinal edema, required maintenance doses of loop diuretics, and poor responsiveness to oral loop diuretics upon admission.
Review
Cardiac & Cardiovascular Systems
Masaki Izumo
Summary: Echocardiography plays a crucial role in understanding cardiac function and hemodynamics in patients with acute HF, despite being highly recommended by guidelines but with limited evidence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kazufumi Nakamura, Toru Miyoshi, Masashi Yoshida, Satoshi Akagi, Yukihiro Saito, Kentaro Ejiri, Naoaki Matsuo, Keishi Ichikawa, Keiichiro Iwasaki, Takanori Naito, Yusuke Namba, Masatoki Yoshida, Hiroki Sugiyama, Hiroshi Ito
Summary: There is a strong correlation between diabetes mellitus and heart failure, with diabetes serving as an independent risk factor for heart failure. The link between diabetes and heart failure is not only due to complications such as ischemic heart disease, but also metabolic disorders like glucose toxicity and lipotoxicity caused by insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Marat Fudim, Nicolas Ashur, Aaron D. Jones, Andrew P. Ambrosy, Bradley A. Bart, Javed Butler, Horng H. Chen, Stephen J. Greene, Yogesh Reddy, Margaret M. Redfield, Abhinav Sharma, Adrian F. Hernandez, Gary Michael Felker, Barry A. Borlaug, Robert J. Mentz
Summary: Among patients with HFpEF, those with oedema tend to have higher body mass index, greater burden of co-morbidities, and more severe exercise intolerance, but clinical responses to treatment appear to be similar.
Article
Medicine, General & Internal
Yaar S. Aga, Sumant P. Radhoe, Dilan Aydin, G. C. M. Linssen, Philip C. Rademaker, Peter R. Geerlings, Marco W. F. van Gent, Ismail Aksoy, Liane Oosterom, Hans-Peter Brunner-La Rocca, Bas M. van Dalen, Jasper J. Brugts
Summary: This study aimed to evaluate heart failure treatment in a large real-world Western European cohort with and without obesity. The results showed that obese patients were more frequently prescribed guideline-recommended medications at higher doses.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Herbert Naegele, Eike Groeene, Daniel Stierle, Matthias P. Nagele
Summary: The life expectancy of patients with ICDs is lower than the general population, with congestive heart failure being the primary cause of death, but with a significant rate of sudden death as well. The occurrence of various cancers, infections, and deaths related to procedures highlight the need for protective measures. Optimizing treatment in multiple directions is required to improve prognosis for this vulnerable cohort of patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Magalie Ladouceur, Teresa Segura de la Cal, Bamba Gaye, Eugenie Valentin, Reaksmei Ly, Laurence Iserin, Antoine Legendre, Elie Mousseaux, Wei Li, Isma Rafiq, Aleksander Kempny, Ana Barradas-Pires, Sonya Babu-Narayan, Michael A. Gatzoulis, Konstantinos Dimopoulos
Summary: An observational study was conducted to estimate the effect of ACE inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) on heart failure (HF) incidence and mortality in patients with a systemic right ventricle (sRV). The study found that not all sRV patients benefited from ACEi or ARB treatment, and it was not significantly associated with lower HF incidence or mortality in this population. Despite significant neurohormonal activation in sRV patients, there is still no evidence of a beneficial effect of ACEi or ARB on morbidity and mortality.
Article
Medicine, General & Internal
Makiko Nakamura, Teruhiko Imamura, Koichiro Kinugawa
Summary: This retrospective study evaluated consecutive patients who received vericiguat between September 2021 and December 2022, and the results suggest that vericiguat therapy may be feasible and effective upon quadruple therapy for patients with heart failure, although further investigation is needed to validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Stephane Heymans, Neal K. Lakdawala, Carsten Tschoepe, Karin Klingel
Summary: Dilated cardiomyopathy is a condition characterized by ventricular dilatation or systolic dysfunction. It can be caused by genetic or acquired factors, such as infections, toxins, and cancer treatment. Diagnostic tests and therapeutic approaches should consider both genetic and acquired factors.
Article
Biochemistry & Molecular Biology
Akira Sezai, Hisakuni Sekino, Makoto Taoka, Shunji Osaka, Masashi Tanaka
Summary: Erythropoiesis-stimulating agents, specifically continuous erythropoietin receptor activator (CERA), have shown positive effects on heart failure with renal anemia by improving NYHA functional class and reducing hospital readmission rates. This prospective study investigated the impact of CERA on cardiac, renal function, and oxidative stress. The results demonstrate that CERA effectively improves anemia, reduces renal impairment, and alleviates cardiac and oxidative stress. The findings of this study are relevant for investigating the switch from CERA to a new drug for renal anemia, such as a hypoxia-inducible factor prolyl-hydroxylase inhibitor.
Article
Biochemistry & Molecular Biology
Mark Sweeney, Katie O'Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei-Wen Lim, Anissa Widjaja, Paul J. R. Barton, Stuart A. Cook
Summary: This study demonstrates that IL11 expression in cardiomyocytes can lead to severe cardiac fibrosis and inflammation, as well as endothelial-to-mesenchymal transition and left ventricular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Javed Butler, Mei Yang, Baanie Sawhney, Sreya Chakladar, Lingfeng Yang, Laurence M. Djatche
Summary: This study evaluated treatment patterns and clinical outcomes in <65 years old patients with chronic HFrEF before and after a WHFE, finding an increase in HF medication use and rehospitalizations post-WHFE despite a decrease in treatment following the event.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Sam Aiyad Ali, Mads Ersboll, Naja Emborg Vinding, Jawad Haider Butt, Rasmus Rorth, Christian Selmer, Lucas Malta Westergaard, Ulrik Madvig Mogensen, Peter E. Weeke, Christian Jons, Finn Gustafsson, Emil Fosbol, Lars Kober, Soren Lund Kristensen
Summary: The incidence of thyroid dysfunction is around 5% in patients initiating amiodarone treatment, with a slightly higher incidence in those with heart failure. There is a dose-response relationship between the accumulated dose of amiodarone and the cumulative incidence of thyroid dysfunction.
Article
Medicine, General & Internal
Onlak Ruangsomboon, Nattakarn Praphruetkit, Apichaya Monsomboon
Summary: This study aims to compare the effects of HFNC and NIPPV in emergency patients with ACPE. The study design is a single-centred, non-blinded, parallel-group, randomised, controlled, non-inferiority trial. The primary outcome is the intubation rate in 72 hours after randomisation.
Article
Cardiac & Cardiovascular Systems
Ovidiu Chioncel, Beth Davison, Marianna Adamo, Laura E. Antohi, Mattia Arrigo, Marianela Barros, Jan Biegus, Kamile Cerlinskaite-Bajore, Jelena Celutkiene, Alain Cohen-Solal, Albertino Damasceno, Rafael Diaz, Christopher Edwards, Gerasimos Filippatos, Antoine Kimmoun, Carolyn S. P. Lam, Marco Metra, Maria Novosadova, Matteo Pagnesi, Peter S. Pang, Piotr Ponikowski, Razvan I. Radu, Hadiza Saidu, Karen Sliwa, Adriaan A. Voors, Koji Takagi, Jozine M. Ter Maaten, Daniela Tomasoni, Gad Cotter, Alexandre Mebazaa
Summary: In the STRONG-HF trial, non-cardiac comorbidities neither limited the rapid up-titration of HF therapies, nor attenuated the benefit of high-intensity care on the primary endpoint.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Wouter Ouwerkerk, Jasper Tromp, John G. F. Cleland, Christiane E. Angermann, Ulf Dahlstrom, Georg Ertl, Mahmoud Hassanein, Sergio Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Kenneth Dickstein, Gerasimos Filippatos, Sean P. Collins, Carolyn S. P. Lam
Summary: In patients with acute heart failure, delayed administration of intravenous diuretics was not significantly associated with in-hospital mortality, but was associated with increased 30-day mortality, especially in high-risk patients. This association was independent of left ventricular ejection fraction or geographic region.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Zachary I. Whinnett, Matthew J. Shun-Shin, Mark Tanner, Paul Foley, Badri Chandrasekaran, Philip Moore, Shaumik Adhya, Norman Qureshi, Amal Muthumala, Rebecca Lane, Aldo Rinaldi, Sharad Agarwal, Francisco Leyva, Jonathan Behar, Sukh Bassi, Andre Ng, Paul Scott, Rachana Prasad, Jon Swinburn, Joseph Tomson, Amarjit Sethi, Jaymin Shah, Phang Boon Lim, Andreas Kyriacou, Dewi Thomas, Jenny Chuen, Ravi Kamdar, Prapa Kanagaratnam, Myril Mariveles, Leah Burden, Katherine March, James P. Howard, Ahran Arnold, Pugazhendhi Vijayaraman, Berthold Stegemann, Nicholas Johnson, Emanuela Falaschetti, Darrel P. Francis, John G. F. Cleland, Daniel Keene
Summary: The study evaluated the effects of optimized His bundle pacing compared to no-pacing in patients with heart failure. It was found that His bundle pacing significantly improved quality of life and was preferred by the majority of patients. However, it did not show any significant changes in peak oxygen uptake or left ventricular ejection fraction.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreirra, John G. Cleland, Nicolas Girerd, Patrick Rossignol, Pierpaolo Pellicori, Franco Cosmi, Beatrice Mariottoni, Arantxa Gonzalez, Javier Diez, Scott D. Solomon, Brian Claggett, Marc A. Pfeffer, Bertram Pitt, Johannes Petutschnigg, Burkert Pieske, Frank Edelmann, Faiez Zannad
Summary: Spironolactone reduces serum concentrations of PICP in patients with HFpEF, indicating its anti-fibrotic effect.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Milton Packer, John G. F. Cleland
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Pierpaolo Pellicori, Francesco Filidei, Lavinia Del Punta, Nicolo De Biase, Alessio Balletti, Valerio Di Fiore, Alessandro Mengozzi, Stefano Taddei, Luna Gargani, Wilfried Mullens, John G. F. Cleland, Stefano Masi
Summary: This study investigated the prevalence and clinical value of assessing multi-organ congestion by ultrasound in heart failure outpatients. It found that patients with multiple ultrasound signs of congestion had the worst prognosis.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, John G. F. Cleland, Nicolas Girerd, Pierpaolo Pellicori, Mark R. Hazebroek, Job Verdonschot, Timothy J. Collier, Johannes Petutschnigg, Andrew L. Clark, Jan A. Staessen, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: The study investigated the effect of spironolactone on QRS duration in patients with stage B HFpEF. Spironolactone was found to significantly reduce the QRS duration after 9 months of treatment, indicating improved myocardial electrical activation. This effect was not associated with changes in LV mass or volume.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
George Markousis-Mavrogenis, Waldemar B. Minich, Ali A. Al-Mubarak, Stefan D. Anker, John G. F. Cleland, Kenneth Dickstein, Chim C. Lang, Leong L. Ng, Nilesh J. Samani, Faiez Zannad, Marco Metra, Petra Seemann, Antonia Hoeg, Patricio Lopez, Dirk J. van Veldhuisen, Rudolf A. de Boer, Adriaan A. Voors, Peter van der Meer, Lutz Schomburg, Nils Bomer
Summary: The study examined the importance of autoantibodies against adrenergic/muscarinic receptors in heart failure. The findings suggest that anti-beta 1 AABs are independently associated with HF rehospitalization, while other AABs are mainly related to comorbidities and medication use.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Girerd, Daniel Levy, Kevin Duarte, Joao Pedro Ferreira, Christie Ballantyne, Timothy Collier, Anne Pizard, Jens Bjoerkman, Javed Butler, Andrew Clark, John G. Cleland, Christian Delles, Javier Diez, Arantxa Gonzalez, Mark Hazebroek, Jennifer Ho, Anne-Cecile Huby, Shih-Jen Hwang, Roberto Latini, Beatrice Mariottoni, Alexandre Mebazaa, Pierpaolo Pellicori, Naveed Sattar, Peter Sever, Jan A. Staessen, Job Verdonschot, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: This study identified protein biomarkers associated with new-onset heart failure in three independent cohorts. The inclusion of these biomarkers in addition to clinical risk factors improved the prediction of heart failure risk. The B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide were found to be particularly relevant in predicting heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Iaconelli, Joe Cuthbert, Syed Kazmi, Pasquale Maffia, Andrew L. Clark, John G. F. Cleland, Pierpaolo Pellicori
Summary: This study found that venous congestion is more closely associated with prognosis in patients with chronic heart failure than pulmonary hypertension.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
John G. F. Cleland, Pierpaolo Pellicori, Fraser J. Graham
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Fraser J. J. Graham, Pierpaolo Pellicori, Paul R. R. Kalra, Ian Ford, Dario Bruzzese, John G. F. Cleland
Summary: This meta-analysis investigates the effect of intravenous iron on clinical outcomes in patients with heart failure. The results suggest that intravenous iron reduces the risk of recurrent heart failure and cardiovascular death, but its impact on cardiovascular and all-cause mortality is inconclusive.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Dimitrios Farmakis, Jasper Tromp, Smaragdi Marinaki, Wouter Ouwerkerk, Christiane E. E. Angermann, Vasiliki Bistola, Ulf Dahlstrom, Kenneth Dickstein, Georg Ertl, Mathieu Ghadanfar, Mahmoud Hassanein, Achim Obergfell, Sergio V. V. Perrone, Eftihia Polyzogopoulou, Anja Schweizer, Ioannis Boletis, John G. F. Cleland, Sean P. P. Collins, Carolyn S. P. Lam, Gerasimos Filippatos
Summary: This study analyzed healthcare resource utilization in patients with heart failure of different ejection fraction types and found high utilization across all three groups. Despite clinical differences, patients with HFmrEF and HFpEF had better long-term cardiovascular outcomes compared to HFrEF. However, the risk for non-cardiovascular events was similar among the groups.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Vincenzo C. C. Leo, Syed Kazmi, Jack Brownrigg, Marzieh Araghi, Harpreet S. S. Sarna, Pierpaolo Pellicori, Joe Cuthbert, John G. F. Cleland, Andrew L. L. Clark
Editorial Material
Cardiac & Cardiovascular Systems
Joe J. Cuthbert, John G. F. Cleland
CARDIOVASCULAR RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Alberto Guarnaccia, Gianfranco Sinagra, John G. F. Cleland