Article
Medicine, General & Internal
Shahid Abbas, Naeem Hameed, Shahbaz Ahmed Khilji, Anjum Jalal
Summary: The study found that thrombolysis has a reasonable success rate in patients with prosthetic valve thrombosis who are in functional class I or II, but has a high mortality rate in patients with functional class III and IV. Common complications include minor bleeding and major bleeding.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Ayesha P. Ng, Arjun Verma, Yas Sanaiha, Catherine G. Williamson, Yalda Afshar, Peyman Benharash
Summary: The guidelines for selecting prosthetic heart valves in reproductive-age individuals are not well established. This study aimed to examine the association between prosthetic valve type and maternal and fetal outcomes in pregnant patients. The findings suggest that women with prior valve replacement surgery are at a substantial risk of adverse maternal and fetal events, regardless of the type of valve used.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medicine, General & Internal
Chunqiang Bai, Haiying Wu, Wenying Wu, Peiming Feng, Minghui Nie, Li Zhao, Fanyue Meng
Summary: This case report and literature review suggest that dose-adjusted LMWH given thrice daily throughout pregnancy is recommended for pregnant women with mechanical heart valves. The combination of LMWH and warfarin exhibited good efficacy for the treatment of small thromboses.
Article
Pharmacology & Pharmacy
Yun-Xia Ni, Lu-Lu Liu, Huang Feng, Zhi Li, Chao-Yi Qin, Miao Chen
Summary: This study aimed to investigate adherence to oral anticoagulants among patients after mechanical heart valve (BHV) replacement and explore the mediating role of medication belief. The results showed that patients with BHV replacement had relatively low adherence to oral anticoagulant therapy. Therefore, efforts should be made to improve patients' knowledge and medication beliefs in order to enhance medication adherence.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Viacheslav V. Danilov, Kirill Y. Klyshnikov, Pavel S. Onishenko, Alex Proutski, Yuriy Gankin, Farid Melgani, Evgeny A. Ovcharenko
Summary: The article introduces a generative design approach that combines machine learning methods and optimization algorithms for optimizing the geometry of prosthetic heart valves. Extensive testing shows that using ensemble methods in conjunction with a Tree-structured Parzen Estimator or a Nondominated Sorting Genetic Algorithm is the most effective method.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Jonathan B. Russ, Richard L. Li, Abigail R. Herschman, Haim Waisman, Vijay Vedula, Jeffrey W. Kysar, David Kalfa
Summary: The text describes a method for optimizing the design of cardiovascular stents, specifically for use in pediatric balloon-expandable prosthetic heart valves. By focusing on a particular design and proposing an appropriate stent to counteract radial retraction of the valved region, the goal is to maintain the desired diameter of the device after a single dilation procedure. The finite element method is used to compute performance metrics and failure criteria, leading to the identification of a single optimal stent design through the use of surrogate models and objective function optimization.
MATERIALS & DESIGN
(2021)
Article
Medicine, General & Internal
Shafaq Nadeem, Shabaz Ahmad Khilji, Faisal Ali, Anjum Jalal
Summary: The study aimed to observe the effects of different doses of warfarin on pregnant women with prosthetic valve replacements. Lower doses of warfarin were found to be safer in terms of fetal outcomes, without causing embryopathy. However, higher doses of warfarin may increase the risk of miscarriages, cesarean sections, low birth weight, and prematurity.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Hongxia Wu, Yongjiang Tang, Xiaofeng Xiong, Min Zhu, He Yu, Deyun Cheng
Summary: This report describes the first case of a pregnant patient who received argatroban during ECMO for thrombocytopenia and summarizes the existing literature on VV-ECMO and argatroban in pregnant patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Obstetrics & Gynecology
Andrea Espiau Romera, Javier Jimeno Sanchez, Javier Navarro Sierra, Teresa Simon Paracuellos, Francisco Javier Villalobos Salguero, Belen Rodriguez Solanilla
Summary: This case report highlights the complexity involved in managing pregnant women with mechanical heart valves, emphasizing the need for adequate interdisciplinary management of this potentially serious pathology for the well-being of both mother and baby. Despite strict control and optimal anticoagulation regimen, pregnant women with mechanical heart valves still face a high risk of developing valve thrombosis.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Luis D. Pacheco, George Saade, Vineet Shrivastava, Raj Shree, Uri Elkayam
Summary: Pregnancy in individuals with a mechanical heart valve is classified as very high risk, requiring special anticoagulation management to prevent complications and mortality. Adjustments to anticoagulation regimens may be made based on valve type, trimester, individual risk tolerance, and timing of delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Monna E. Myllykangas, Tuomas O. Kiviniemi, Jarmo M. Gunn, Veikko V. Salomaa, Arto Pietila, Teemu J. Niiranen, Jenni Aittokallio
Summary: The use of oral anticoagulants after BAVR was associated with an increased risk of stroke but a decreased risk of death. These observational results need to be validated in randomized controlled trials before any clinical conclusions can be drawn.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Barbara Wichert-Schmitt, Jasmine Grewal, A. Kinga Malinowski, Birgit Pfaller, Katie L. Losenno, Marla C. Kiess, Jack M. Colman, Wendy Tsang, Jennifer Mason, Samuel C. Siu, Candice K. Silversides
Summary: This study examined the outcomes of pregnant women with bioprosthetic valves (BPVs) and the association with structural valve dysfunction (SVD). The results showed that SVD negatively affected pregnancy outcomes, particularly in cases of left-sided BPV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Tommaso D'Angelo, Giampiero Vizzari, Ludovica R. M. Lanzafame, Federica Pergolizzi, Silvio Mazziotti, Michele Gaeta, Francesco Costa, Gianluca Di Bella, Thomas J. J. Vogl, Christian Booz, Antonio Micari, Alfredo Blandino
Summary: Transcatheter heart valve (THV) embolization is a rare complication of transcatheter aortic valve implantation (TAVI), and it is caused by malpositioning, sizing inaccuracies, and pacing failures. The consequences of embolization vary depending on the site, ranging from asymptomatic when the device is stable in the descending aorta to potentially fatal outcomes such as obstruction of vital organ flow, aortic dissection, and thrombosis. In this case, a severely obese 65-year-old woman with severe aortic valve stenosis underwent TAVI complicated by device embolization. Spectral CT angiography with virtual monoenergetic reconstructions was performed for improved image quality and optimal pre-procedural planning. The patient was successfully re-treated with a second prosthetic valve implantation a few weeks later.
Article
Cardiac & Cardiovascular Systems
Jennifer L. Smerling, Andrew B. Goldstone, Emile A. Bacha, Leonardo Liberman
Summary: The study aims to evaluate the long-term outcomes after tricuspid valve intervention during stage 2 palliation in patients with right ventricular dominant circulation in a multicenter study.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Gurmandeep S. Sandhu, Pratik S. Velangi, Harmeet Kharoud, Rebecca Freese, Jeremy Markowitz, Felipe Kazmirczak, Prabhjot S. Nijjar
Summary: This study investigated the prognostic value of computed tomography (CT) evaluation of prosthetic valve dysfunction (PVD) etiology for adverse clinical outcomes. The results showed that in patients with suspected PVD, CT assessment of structural valve degeneration (SVD) had significant prognostic significance for hard outcomes.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Cecconi, Jean Paul Vilchez-Tschischke, Jesus Mateo, Javier Sanchez-Gonzalez, Samuel Espana, Rodrigo Fernandez-Jimenez, Beatriz Lopez-Melgar, Leticia Fernandez Friera, Gonzalo J. Lopez-Martin, Valentin Fuster, Jesus Ruiz-Cabello, Borja Ibanez
Summary: The study found that colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, particularly in animals with high cholesterol levels.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Xiaoyan Yin, Christine M. Willinger, Joshua Keefe, Jun Liu, Antonio Fernandez-Ortiz, Borja Ibanez, Jose Penalvo, Aram Adourian, George Chen, Dolores Corella, Reinald Pamplona, Manuel Portero-Otin, Mariona Jove, Paul Courchesne, Cornelia M. van Duijn, Valentin Fuster, Jose M. Ordovas, Ayse Demirkan, Martin G. Larson, Daniel Levy
Article
Cardiac & Cardiovascular Systems
Carlos Galan-Arriola, Rocio Villena-Gutierrez, Maria Higuero-Verdejo, Ivan A. Diaz-Rengifo, Gonzalo Pizarro, Gonzalo J. Lopez, Antonio de Molina-Iracheta, Claudia Perez-Martinez, Rodrigo D. Garcia, David Gonzalez-Calle, Manuel Lobo, Pedro L. Sanchez, Eduardo Oliver, Raul Cordoba, Valentin Fuster, Javier Sanchez-Gonzalez, Borja Ibanez
Summary: This study demonstrates that RIPC applied immediately before each doxorubicin injection can preserve cardiac contractility, result in significantly higher long-term left ventricular ejection fraction, and less cardiac fibrosis in a translatable large-animal model of AIC. RIPC is able to prevent mitochondrial fragmentation and dysregulated autophagy from AIC early stages, suggesting it as a promising intervention for testing in clinical trials for AIC.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Rachel Climie, Valentin Fuster, Jean-Philippe Empana
Article
Medicine, General & Internal
Marta Gonzalez-Sanchez, Fernando Bartolome, Desiree Antequera, Veronica Puertas-Martin, Pilar Gonzalez, Adolfo Gomez-Grande, Sara Llamas-Velasco, Alejandro Herrero-San Martin, David Perez-Martinez, Alberto Villarejo-Galende, Mercedes Atienza, Miriam Palomar-Bonet, Jose Luis Cantero, George Perry, Gorka Orive, Borja Ibanez, Hector Bueno, Valentin Fuster, Eva Carro
Editorial Material
Cardiac & Cardiovascular Systems
Samin K. Sharma, Valentin Fuster, Leonard Hofstra, Annapoorna S. Kini, Arthur Gianelli, Jagat Narula
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Jose A. de la Chica, Sandra Gomez-Talavera, Jose M. Garcia-Ruiz, Ines Garcia-Lunar, Belen Oliva, Juan M. Fernandez-Alvira, Beatriz Lopez-Melgar, Javier Sanchez-Gonzalez, Jose L. de la Pompa, Jose M. Mendiguren, Vicente Martinez de Vega, Antonio Fernandez-Ortiz, Javier Sanz, Leticia Fernandez-Friera, Borja Ibanez, Valentin Fuster
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Paul W. Armstrong, Valentin Fuster
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Urology & Nephrology
Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Riccardo Miotto, Anuradha Lala, Arash Kia, Prem Timsina, Li Li, Robert Freeman, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin Fuster, Barbara Murphy, John C. He, Alexander W. Charney, Erwin P. Boettinger, Benjamin S. Glicksberg, Steven G. Coca, Girish N. Nadkarni
Summary: The study found that AKI is common among hospitalized COVID-19 patients in the United States, with a 46% occurrence rate and 19% of patients requiring dialysis. Independently predicting severe AKI were chronic kidney disease, male gender, and higher serum potassium levels at admission. In-hospital mortality was significantly higher in patients with AKI compared to those without AKI, with only 30% of AKI patients recovering kidney function by the time of discharge.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rebeca Lorca, Marta Jimenez-Blanco, Jose Manuel Garcia-Ruiz, Gonzalo Pizarro, Rodrigo Fernandez-Jimenez, Ana Garcia-Alvarez, Leticia Fernandez-Friera, Manuel Lobo-Gonzalez, Valentin Fuster, Xavier Rossello, Borja Ibanez
Summary: This study assessed the transmural and lateral spread of myocardial damage in patients with acute myocardial infarction. It found that myocardial scarring decreased significantly in both the transmural and lateral dimensions 6 months after the event, indicating infarct resorption. The study also showed that myocardial salvage occurs in both transmural and lateral directions.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos G. Santos-Gallego, Ariana P. Vargas-Delgado, Juan Antonio Requena-Ibanez, Alvaro Garcia-Ropero, Donna Mancini, Sean Pinney, Frank Macaluso, Samantha Sartori, Merce Roque, Fernando Sabatel-Perez, Anderly Rodriguez-Cordero, M. Urooj Zafar, Icilma Fergus, Farah Atallah-Lajam, Johanna P. Contreras, Cathleen Varley, Pedro R. Moreno, Vivian M. Abascal, Anuradha Lala, Ronald Tamler, Javier Sanz, Valentin Fuster, Juan J. Badimon
Summary: This study found that empagliflozin significantly improved left ventricular function and volumes, functional capacity, and quality of life in nondiabetic HFrEF patients, compared to placebo. The observations strongly support the role of sodium-glucose cotransporter 2 inhibitors in the treatment of HFrEF patients regardless of their glycemic status.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos G. Santos-Gallego, Juan Antonio Requena-Ibanez, Rodolfo San Antonio, Alvaro Garcia-Ropero, Kiyotake Ishikawa, Shin Watanabe, Belen Picatoste, Ariana P. Vargas-Delgado, Eduardo J. Flores-Umanzor, Javier Sanz, Valentin Fuster, Juan J. Badimon
Summary: The study aimed to investigate the effect of empagliflozin on diastolic function in non-diabetic heart failure patients and the pathways causing diastolic dysfunction. Empagliflozin was found to improve diastolic function in non-diabetic HF patients, mitigates histological and molecular remodeling, and reduces both left ventricle and cardiomyocyte stiffness.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Alejandro Lopez-Escobar, Rodrigo Madurga, Jose Maria Castellano, Sara Velazquez, Rafael Suarez del Villar, Justo Menendez, Alejandro Peixoto, Sara Jimeno, Paula Sol Ventura, Santiago Ruiz de Aguiar
Summary: Various models incorporating different variables can accurately predict in-hospital mortality risk for COVID-19 patients. NLR and NPR models performed similarly in both training and validation cohorts, with AUC values of 0.885 and 0.891 for VNLR and VNPR in the validation cohort respectively.
Article
Cardiac & Cardiovascular Systems
Jesus Alvarez-Garcia, Samuel Lee, Arjun Gupta, Matthew Cagliostro, Aditya A. Joshi, Mercedes Rivas-Lasarte, Johanna Contreras, Sumeet S. Mitter, Gina LaRocca, Pilar Tlachi, Danielle Brunjes, Benjamin S. Glicksberg, Matthew A. Levin, Girish Nadkarni, Zahi Fayad, Valentin Fuster, Donna Mancini, Anuradha Lala
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Gennaro Giustino, Lori B. Croft, Giulio G. Stefanini, Renato Bragato, Jeffrey J. Silbiger, Marco Vicenzi, Tatyana Danilov, Nina Kukar, Nada Shaban, Annapoorna Kini, Anton Camaj, Solomon W. Bienstock, Eman R. Rashed, Karishma Rahman, Connor P. Oates, Samantha Buckley, Lindsay S. Elbaum, Derya Arkonac, Ryan Fiter, Ranbir Singh, Emily Li, Victor Razuk, Sam E. Robinson, Michael Miller, Benjamin Bier, Valeria Donghi, Marco Pisaniello, Riccardo Mantovani, Giuseppe Pinto, Irene Rota, Sara Baggio, Mauro Chiarito, Fabio Fazzari, Ignazio Cusmano, Mirko Curzi, Richard Ro, Waqas Malick, Mazullah Kamran, Roopa Kohli-Seth, Adel M. Bassily-Marcus, Eric Neibart, Gregory Serrao MD, Gila Perk, Donna Mancini, Vivek Y. Reddy, Sean P. Pinney, George Dangas, Francesco Blasi, Samin K. Sharma, Roxana Mehran, Gianluigi Condorelli, Gregg W. Stone, Valentin Fuster, Stamatios Lerakis, Martin E. Goldman
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)