Article
Agriculture, Dairy & Animal Science
Laura Nath, Andrew Stent, Adrian Elliott, Andre La Gerche, Samantha Franklin
Summary: Understanding the causes of racehorse deaths is crucial for addressing welfare concerns. Catastrophic musculoskeletal injuries account for 75% of fatalities during racing, while sudden cardiac death is responsible for the remaining 25%. Risk factors for sudden cardiac death include dying during training, fewer lifetime starts, and being a castrated male.
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsartsalis, Dafni Korela, Lars O. Karlsson, Emmanouil Foukarakis, Anneli Svensson, Aris Anastasakis, Dimitrios Venetsanos, Constantina Aggeli, Costas Tsioufis, Frieder Braunschweig, Elena Dragioti, Emmanouil Charitakis
Summary: This study reviewed the modifiable risk and protective factors of sudden cardiac death (SCD). Observational studies showed that diabetes mellitus, smoking, and early repolarization pattern are risk factors for SCD, while implanted cardiac defibrillator and physical activity are protective factors. Randomized controlled trials identified mineralocorticoid receptor antagonist, beta-blockers, sodium-glucose cotransporter-2 inhibitors, and implanted cardiac defibrillator as credible protective factors in patients with heart failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Deepthi Rajan, Rodrigue Garcia, Jesper Svane, Jacob Tfelt-Hansen
Summary: This review focuses on sports-related sudden cardiac death (SrSCD) in females, summarizing epidemiology, characteristics, causes, and potential mechanisms behind gender differences. Proposed mechanisms for SrSCD in females include sex-specific variations in hormones, blood pressure, and autonomic tone, impacting cardiac adaptations and the occurrence of ventricular arrhythmias. While literature on the aetiology of SrSCD in females is limited, understanding these biological differences may help identify females at high risk and develop targeted prevention strategies.
EUROPEAN HEART JOURNAL
(2022)
Article
Chemistry, Analytical
Josue R. Velazquez-Gonzalez, Hayde Peregrina-Barreto, Jose J. Rangel-Magdaleno, Juan M. Ramirez-Cortes, Juan P. Amezquita-Sanchez
Summary: Sudden Cardiac Death (SCD) can be detected in advance using ECG signals with a high accuracy rate. The proposed sparse representation technique offers practicality and flexibility in identifying SCD episodes before they occur.
Article
Cardiac & Cardiovascular Systems
Santo Ricceri, James W. Salazar, Andrew A. Vu, Eric Vittinghoff, Ellen Moffatt, Zian H. Tseng
Summary: In this 4-year countywide study of OHCAs, only one-third were sudden, of which one-half were resuscitated to hospitalization and 1 in 5 survived to discharge. Arrhythmic cause predicted survival and nearly one-half of nonsurvivors had nonarrhythmic causes, suggesting that SCA survivors are not equivalent to SCDs. Early identification of nonarrhythmic SCAs, such as neurologic emergencies, may be a target to improve OHCA survival.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hoang Nhat Pham, Lauri Holmstrom, Harpriya Chugh, Audrey Uy-Evanado, Kotoka Nakamura, Zijun Zhang, Angelo Salvucci, Jonathan Jui, Kyndaron Reinier, Sumeet S. Chugh
Summary: This study investigates the importance and prevalence of dynamic electrocardiogram (ECG) remodeling in sudden cardiac death (SCD) and finds that dynamic ECG remodeling improves SCD risk prediction.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Sudhir Kurl, Sae Young Jae, Ari Voutilainen, Magnus Hagnas, Jari A. Laukkanen
Summary: The study found that delayed exercise heart rate reserve and slow heart rate recovery predicted the risk of SCD in the general male population, with each unit increment decreasing the incidence of SCD by 1-2%.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Medicine, General & Internal
Luigi Pannone, Giulio Falasconi, Lorenzo Cianfanelli, Luca Baldetti, Francesco Moroni, Roberto Spoladore, Pasquale Vergara
Summary: Sudden cardiac death is a major cause of mortality in patients with certain heart diseases, with ongoing research focused on improving risk stratification to identify patients who would benefit from ICD implantation. Despite high levels of available data, there are currently no clear recommendations to reduce the risk of sudden cardiac death in these patient populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ke Gong, Kai Yang, Ting Xie, Yong Luo, Hui Guo, Zhiping Tan, Jinlan Chen, Qin Wu, Yibo Gong, Luyao Wei, Jinwen Luo, Yao Yao, Yifeng Yang, Li Xie
Summary: By analyzing gene expression files in the GEO database, this study identified differentially expressed circRNAs, miRNAs, and mRNAs in HCM, and predicted the target molecules of circRNAs and miRNAs. A ceRNA network was constructed by calculating the intersection of these differentially expressed RNA molecules and their expected targets. Functional enrichment analysis revealed the potential etiology of HCM, which is associated with calcium channel release. The qPCR results showed differential expression levels of circRNA, miRNA, and mRNA, suggesting their potential as noninvasive indicators for early screening and prognostic prediction of HCM.
Article
Veterinary Sciences
Ingunn Risnes Hellings, Eystein Skjerve, Erika Karlstam, Mette Valheim, Carl Fredrik Ihler, Constanze Fintl
Summary: This study investigated the fatalities and causes of death in harness racehorses in Norway and Sweden between 2014 and 2019. The results showed that sudden death accounted for 85.5% of the fatalities. An increase in the number of race starts within the last 30 days was associated with a higher risk of sudden death. Hemorrhage after vessel rupture was the primary cause of death in some cases.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maria-Christina Kotta, Margherita Torchio, Pauline Bayliss, Marta C. Cohen, Oliver Quarrell, Nigel Wheeldon, Tamas Marton, Davide Gentilini, Lia Crotti, Robert C. Coombs, Peter J. Schwartz
Summary: This study analyzed the genetic factors of SIDS and SUDC and found that SUDC has a higher genetic yield than SIDS. Additionally, cascade family screening was conducted, and a correlation was found between genetic variant status and phenotype. The results suggest that the anonymity of the disease is no longer justifiable and that cardiac channelopathies may play a significant role in SUDC.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Gabrielle Norrish, Cristian Topriceanu, Chen Qu, Ella Field, Helen Walsh, Lidia Ziolkowska, Iacopo Olivotto, Silvia Passantino, Silvia Favilli, Aris Anastasakis, Vasiliki Vlagkouli, Robert Weintraub, Ingrid King, Elena Biagini, Luca Ragni, Terrence Prendiville, Sophie Duignan, Karen McLeod, Maria Ilina, Adrian Fernandez, Regina Bokenkamp, Anwar Baban, Fabrizio Drago, Peter Kubus, Piers E. F. Daubeney, Sian Chivers, Georgia Sarquella-Brugada, Sergi Cesar, Chiara Marrone, Constancio Medrano, Reyes Alvarez Garcia-Roves, Orhan Uzun, Ferran Gran, Fernandez J. Castro, Juan R. Gimeno, Roberto Barriales-Villa, Fernando Rueda, Satish Adwani, Jonathan Searle, Tara Bharucha, Ana Siles, Ana Usano, Torsten B. Rasmussen, Caroline B. Jones, Toru Kubo, Jens Mogensen, Zdenka Reinhardt, Elena Cervi, Perry M. Elliott, Rumana Z. Omar, Juan P. Kaski
Summary: This study aimed to describe the ECG phenotype of childhood HCM in a large, international, multi-centre cohort and investigate its role in risk prediction for arrhythmic events. The results showed that ECG abnormalities were common in childhood HCM, but none of them were associated with 5-year arrhythmic events, suggesting limited role of baseline ECG phenotype in improving risk stratification in childhood HCM.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Yun Gi Kim, Kyungdo Han, Joo Hee Jeong, Seung-Young Roh, Yun Young Choi, Kyongjin Min, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: Metabolic syndrome and gamma-GTP are associated with an increased risk of sudden cardiac death (SCD). The risk of SCD increases linearly with higher metabolic syndrome diagnostic criteria. Temporal changes in metabolic syndrome and gamma-GTP also correlate with SCD risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fredrik Landfors, Simon Vikstrom, Patrik Wennberg, Jan-Hakan Jansson, Jonas Andersson, Elin Chorell
Summary: This study found that two proteins, LTA4H and HGF, which are linked to inflammation and tissue damage, are independently associated with an increased risk of SCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yun Gi Kim, Kyung-Do Han, Seung-Young Roh, Joo Hee Jeong, Yun Young Choi, Kyongjin Min, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: This study found that being underweight is significantly associated with an increased risk of sudden cardiac death in people with diabetes. Individuals with a BMI below 18.5 had a 2.4-fold increased risk of sudden cardiac death during the follow-up period. Comparatively, the underweight group had a higher risk of sudden cardiac death compared to the obese group.
JOURNAL OF CLINICAL MEDICINE
(2023)