Generation of cell-based systems to visualize chromosome damage and translocations in living cells

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Chromatin Movement in the Maintenance of Genome Stability

(2013) Vincent Dion et al.   CELL

Live visualization of chromatin dynamics with fluorescent TALEs

(2013) Yusuke Miyanari et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spatial Dynamics of Chromosome Translocations in Living Cells

(2013) V. Roukos et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Chromosome territories reposition during DNA damage-repair response

(2013) Ishita S Mehta et al.   GENOME BIOLOGY

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

(2012) Martijn S Luijsterburg et al.   EMBO JOURNAL

Chromatin mobility is increased at sites of DNA double-strand breaks

(2012) P. M. Krawczyk et al.   JOURNAL OF CELL SCIENCE

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

Increased chromosome mobility facilitates homology search during recombination

(2012) Judith Miné-Hattab et al.   NATURE CELL BIOLOGY

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

(2012) Athanasia Stathopoulou et al.   PLoS One

Live-Cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events during ES Cell Differentiation

(2011) Osamu Masui et al.   CELL

Lac operator repeats generate a traceable fragile site in mammalian cells

(2011) Ariana Jacome et al.   EMBO REPORTS

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

ATP-dependent and independent functions of Rad54 in genome maintenance

(2011) Sheba Agarwal et al.   JOURNAL OF CELL BIOLOGY

Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage

(2011) V. Roukos et al.   JOURNAL OF CELL SCIENCE

Nucleation of nuclear bodies by RNA

(2011) Sergey P. Shevtsov et al.   NATURE CELL BIOLOGY

Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector

(2011) Eirini P Papapetrou et al.   Nature Protocols

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The emerging role of nuclear architecture in DNA repair and genome maintenance

(2009) Tom Misteli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Live cell microscopy analysis of radiation-induced DNA double-strand break motion

(2009) B. Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA repair: easy to visualize, difficult to elucidate

(2009) Zita Nagy et al.   TRENDS IN CELL BIOLOGY

A Fluorescent Two-hybrid Assay for Direct Visualization of Protein Interactions in Living Cells

(2008) Kourosh Zolghadr et al.   MOLECULAR & CELLULAR PROTEOMICS

Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage

(2008) Carla Yaneth Bonilla et al.   MOLECULAR CELL

Induction of linear tracks of DNA double-strand breaks by α-particle irradiation of cells

(2008) Jan Stap et al.   NATURE METHODS

Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

(2008) Elijahu Berkovich et al.   Nature Protocols

Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

(2008) S. Nagai et al.   SCIENCE

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE

De Novo Formation of a Subnuclear Body

(2008) T. E. Kaiser et al.   SCIENCE

Modules for cloning-free chromatin tagging inSaccharomyces cerevisae

(2008) Sabine Rohner et al.   YEAST