Article
Physics, Applied
Shamiul Alam, Md Mazharul Islam, Md Shafayat Hossain, Akhilesh Jaiswal, Ahmedullah Aziz
Summary: The scaling of complementary metal-oxide-semiconductor technology is reaching its physical limit, prompting the search for alternative solutions. Cryogenic operation offers potential for improved computing speed and energy efficiency. However, the memory bottleneck still exists, even at cryogenic temperature. This is where the compute-in-memory (CiM) architecture, which combines computing and memory, comes into play. CiM reduces data transfer between memory and computing units, resulting in extreme energy efficiency.
APPLIED PHYSICS LETTERS
(2022)
Review
Biochemical Research Methods
Shixiu Cui, Xueqin Lv, Xianhao Xu, Taichi Chen, Hongzhi Zhang, Yanfeng Liu, Jianghua Li, Guocheng Du, Rodrigo Ledesma-Amaro, Long Liu
Summary: Dynamic regulation of metabolic pathways involves complex genetic circuits to process various signals and control metabolic flux for optimal synthesis of target molecules.
ACS SYNTHETIC BIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Mert Erginkaya, M. Eugenia Chiappe
Summary: Processing visual motion cues is crucial for animals to interpret self-motion, the movement of others, and the environment's structure, regardless of being prey or predator. A recent study in Drosophila has identified multiple pathways that are likely to contribute to visual motion-dependent computations and behaviors.
Article
Materials Science, Multidisciplinary
Meryem Uzun-Per, Gregory J. Gillispie, Thomas Erol Tavolara, James J. Yoo, Anthony Atala, Metin Nafi Gurcan, Sang Jin Lee, Muhammad Khalid Khan Niazi
Summary: The lack of suitable bioinks for bioprinting is a major limitation in tissue engineering and regenerative medicine, primarily due to the contradictory requirements of bioinks needing to exhibit desirable bioactivity while also being highly printable. This study proposes methods and tools for automatically quantifying the performance of bioinks, reducing the time and effort needed for analysis and providing a standardized set of tools for comparison.
ADVANCED ENGINEERING MATERIALS
(2021)
Review
Cell Biology
Maysam Mansouri, Martin Fussenegger
Summary: Cell therapy approaches utilizing engineered mammalian cells for on-demand production of therapeutic agents in the patient's body have advanced beyond proof-of-concept in translational medicine. Customized therapeutic cells can sense user-defined signals, process them, and respond programmably. Various methods of controlling cell behavior, including open-loop and closed-loop systems, are discussed, along with therapeutic applications of engineered cells in early disease diagnosis and treatment. Emerging technologies like digital devices also show potential for future incorporation into cell-based therapies.
Article
Psychiatry
G. Kastrati, J. Rosen, M. Fredrikson, X. Chen, R. Kuja-Halkola, H. Larsson, K. B. Jensen, F. Ahs
Summary: This study used a classical twin design and functional magnetic resonance imaging to evaluate the genetic influences on brain activity and autonomic responses during fear conditioning. The results showed that both mean brain activation and autonomic responses during fear learning were genetically influenced. The study also found a genetic influence on brain activation during safety learning. The mean safety-related brain activation was genetically correlated with autonomic responses, while fear-related brain activation was not.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Engineering, Electrical & Electronic
Jian Chen, Wenfeng Zhao, Yuqi Wang, Yajun Ha
Summary: This paper investigates the dynamic read disturbance issues of 6T SRAM and proposes solutions such as maintaining high bitline voltage, designing a new sense amplifier, and implementing an adaptive wordline control scheme to effectively address the problem. Experimental results in a 55nm CMOS technology demonstrate improved reliability and performance compared to state-of-the-art designs using advanced 28nm FDSOI technology.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2021)
Article
Zoology
Sara M. Hiebert
Summary: Interactive engagement and general principles are identified as the two most important learning practices in the classroom, where the former encourages active student participation and the latter teaches them to recognize patterns in the natural world and in their learning.
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Noa Liscovitch-Brauer, Antonino Montalbano, Jiale Deng, Alejandro Mendez-Mancilla, Hans-Hermann Wessels, Nicholas G. Moss, Chia-Yu Kung, Akash Sookdeo, Xinyi Guo, Evan Geller, Suma Jaini, Peter Smibert, Neville E. Sanjana
Summary: Researchers have developed a single-cell combinatorial indexing assay called CRISPR-sciATAC, which links genetic perturbations to genome-wide chromatin accessibility in a large number of cells. By targeting 105 chromatin-related genes in human myelogenous leukemia cells, they found that loss of specific chromatin remodelers affects chromatin accessibility and triggers gene expression.
NATURE BIOTECHNOLOGY
(2021)
Correction
Engineering, Electrical & Electronic
Alireza Asoodeh, Hossein Miri Lavasani, Mengye Cai, Shahriar Mirabbasi
Summary: The authors report typos and a missing definition for $N in the above article.
IEEE JOURNAL OF SOLID-STATE CIRCUITS
(2021)
Article
Multidisciplinary Sciences
Yi Li, Mohammad Mahdi Bidmeshki, Taek Kang, Chance M. Nowak, Yiorgos Makris, Leonidas Bleris
Summary: A physical unclonable function (PUF) is a physical entity that provides a unique and irreproducible identifier for an embedded artifact. We have successfully created the first generation of genetic PUFs in human cells and demonstrated their robustness, uniqueness, and unclonability. Furthermore, we have shown that CRISPR-PUFs can serve as a foundational principle for establishing provenance attestation protocols.
Article
Engineering, Electrical & Electronic
Yangzhan Mai, Mingyu Wang, Baiqing Zhong, Chuanghao Zhang, Yicong Zhang, Zhiyi Yu
Summary: This work proposes a novel SRAM-CIM design that supports high-precision DNN computing. It utilizes efficient bit-parallel exponent operations and a bitwise booth encoder to reduce mantissa multiplication latency in order to maximize energy efficiency. By enabling the pipeline of exponent and mantissa processing, hardware utilization is improved and high throughput is achieved, resulting in a frequency of 714 MHz and a peak energy efficiency of 1.53 TFLOPS/W in 40 nm CMOS technology.
ELECTRONICS LETTERS
(2023)
Article
Optics
Jian Zhou, Sai Li, Guo-Zhu Pan, Gang Zhang, Tao Chen, Zheng-Yuan Xue
Summary: This study demonstrates high-fidelity geometric quantum gates using path-design strategy, showing robustness against different types of errors and promising practical applications.
Article
Psychology, Mathematical
Joyce Tam, Michael K. Mugno, Ryan E. O'Donnell, Brad Wyble
Summary: Attribute amnesia refers to the difficulty participants face in recalling specific details about a recently attended stimulus when unexpectedly asked. This phenomenon can also be observed in real-life situations such as eyewitness identification, where individuals may struggle to remember a face they had just seen. The study found that this attribute amnesia can lead to inaccuracies in face identification, even when minimal decay or interference is present, potentially explaining certain failures in eyewitness identification.
PSYCHONOMIC BULLETIN & REVIEW
(2021)
Review
Chemistry, Analytical
Corwin A. Miller, Joanne M. L. Ho, Matthew R. Bennett
Summary: This article reviews the known types of mechanisms of biosensors within bacterial cells and discusses different approaches for optimizing biosensor functional parameters, including gene engineering, selection of genetic reporters, gene expression tuning, and incorporation of additional genetic modules.
