Microfluidic mixer designed for performing single-molecule kinetics with confocal detection on timescales from milliseconds to minutes

Single-molecule spectroscopy of protein folding dynamics—expanding scope and timescales

(2013) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Single-Molecule Views of Protein Movement on Single-Stranded DNA

(2012) Taekjip Ha et al.   Annual Review of Biophysics

Measuring ultrafast protein folding rates from photon-by-photon analysis of single molecule fluorescence trajectories

(2012) Hoi Sung Chung et al.   CHEMICAL PHYSICS

Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy

(2012) A. Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy

(2012) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Molecule Fluorescence Experiments Determine Protein Folding Transition Path Times

(2012) H. S. Chung et al.   SCIENCE

Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy

(2012) Alessandro Borgia et al.   Nature Communications

Fluorescence Correlation Spectroscopy of Fast Chain Dynamics within Denatured Protein L

(2011) Eilon Sherman et al.   CHEMPHYSCHEM

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing

(2011) Yann Gambin et al.   NATURE METHODS

Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP)

(2011) Armin Hoffmann et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Single-molecule fluorescence spectroscopy maps the folding landscape of a large protein

(2011) Menahem Pirchi et al.   Nature Communications

Ribosome Structure and Dynamics During Translocation and Termination

(2010) Jack A. Dunkle et al.   Annual Review of Biophysics

Extracting Rate Coefficients from Single-Molecule Photon Trajectories and FRET Efficiency Histograms for a Fast-Folding Protein

(2010) Hoi Sung Chung et al.   JOURNAL OF PHYSICAL CHEMISTRY A

FRET Efficiency Distributions of Multistate Single Molecules

(2010) Irina V. Gopich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Application of dual-focus fluorescence correlation spectroscopy to microfluidic flow-velocity measurement

(2010) Tyler J. Arbour et al.   LAB ON A CHIP

Single-molecule spectroscopy of protein folding in a chaperonin cage

(2010) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping vortex-like hydrodynamic flow in microfluidic networks using fluorescence correlation spectroscopy

(2009) Ke Liu et al.   ANALYTICA CHIMICA ACTA

Microfluidic Device for Single-Molecule Experiments with Enhanced Photostability

(2009) Edward A. Lemke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A vacuum manifold for rapid world-to-chip connectivity of complex PDMS microdevices

(2009) Gregory A. Cooksey et al.   LAB ON A CHIP

Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics

(2009) Yann Gambin et al.   LAB ON A CHIP

The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism

(2009) Marcus Mueller et al.   NATURE

Direct observation of ultrafast folding and denatured state dynamics in single protein molecules

(2009) H. Neuweiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories

(2009) H. S. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule spectroscopy of the temperature-induced collapse of unfolded proteins

(2009) D. Nettels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic mixing system for single-molecule measurements

(2009) Shawn H. Pfeil et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Biology, one molecule at a time

(2009) Achillefs N. Kapanidis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Microfluidic Mixers for the Investigation of Rapid Protein Folding Kinetics Using Synchrotron Radiation Circular Dichroism Spectroscopy

(2008) Avinash S. Kane et al.   ANALYTICAL CHEMISTRY

Translation at the Single-Molecule Level

(2008) R. Andrew Marshall et al.   Annual Review of Biochemistry

Nonequilibrium Single Molecule Protein Folding in a Coaxial Mixer

(2008) Kambiz M. Hamadani et al.   BIOPHYSICAL JOURNAL