Editorial Material
Microbiology
Mark R. Sullivan, Eric J. Rubin, Charles L. Dulberger
Summary: Mycobacterium abscessus (Mab) is highly tolerant to current antibiotic therapies, leading to a high failure rate of standard care. Phages may offer a promising alternative treatment with few side effects. Two studies shed light on the natural phage complement of Mab and the factors that may drive susceptibility to these phages, paving the way for more effective phage therapy development.
Article
Clinical Neurology
Joseph F. Bohlen, Colin M. Cleary, Debamitra Das, Srinidhi Rao Sripathy, Norah Sadowski, Gina Shim, Rakaia F. Kenney, Ingrid P. Buchler, Tapasree Banerji, Thomas S. Scanlan, Daniel K. Mulkey, Brady J. Maher
Summary: In this study, the researchers found that three promyelinating compounds can restore myelination defects in a Pitt-Hopkins syndrome mouse model. Clemastine treatment reduced excess oligodendrocyte precursor cells and normalized oligodendrocyte density. Treatment with sobetirome or Sob-AM2 also effectively normalized oligodendrocyte precursor cell and oligodendrocyte densities and improved behavior in the Pitt-Hopkins syndrome mouse model. These findings suggest that promyelinating therapies may be beneficial in Pitt-Hopkins syndrome and other neurodevelopmental disorders characterized by dysmyelination.
Article
Multidisciplinary Sciences
Nisha Pillay, Laura Mariotti, Mariola Zaleska, Oviya Inian, Matthew Jessop, Sam Hibbs, Ambroise Desfosses, Paul C. R. Hopkins, Catherine M. Templeton, Fabienne Beuron, Edward P. Morris, Sebastian Guettler
Summary: This research reveals the structure of the active unit filament of tankyrase and shows how its catalytic and non-catalytic functions are controlled by polymerization. The cryo-electron microscopy reconstruction provides detailed insights into the interactions between the SAM domain and the catalytic domain, as well as the role of head-to-head and tail-to-tail interactions at the active site.
Article
Cell & Tissue Engineering
Yongbin Ma, Dan Zhou, Huanyan Zhang, Liming Tang, Fen Qian, Jianhua Su
Summary: This study demonstrates for the first time that human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote Schwann cell proliferation by activating the PI3K/AKT signaling pathway, thus mediating nerve regeneration. This novel mechanism suggests that these extracellular vesicles may be an attractive option for treating peripheral nerve injuries.
STEM CELLS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Xuchen Zhang, Pei-Yi Lin, Kif Liakath-Ali, Thomas C. Sudhof
Summary: Teneurins on the presynaptic side are essential for establishing synaptic connections, and Teneurin-3 assembles into presynaptic nanoclusters in excitatory synapses of the hippocampus. The study demonstrates that Teneurin-3 and Teneurin-4 are required for the assembly of specific synapses in the medial entorhinal cortex.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Anjali Yadav, Tzu-Chieh Huang, Szu-Han Chen, Thamil Selvee Ramasamy, Yuan-Yu Hsueh, Shau-Ping Lin, Fu- Lu, Ya-Hsin Liu, Chia-Ching Wu
Summary: Inhibiting prolonged inflammation through HDAC inhibitor PBA treatment can suppress the expression and secretion of pro-inflammatory cytokines in SCs, favoring axonal regrowth and remyelination to create a conducive microenvironment for peripheral nerve regeneration.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Jerome Perrard, Susan Smith
Summary: Tankyrase 1 and 2 are regulated by RNF146-mediated K48-linked polyubiquitylation and degradation. The authors discovered a novel interaction between tankyrase and the RING-UIM family of E3 ligases. They found that RNF114 and RNF166 bind and stabilize monoubiquitylated tankyrase and promote K11-linked diubiquitylation. This process competes with RNF146-mediated degradation, leading to the stabilization of tankyrase and its binding partner Angiomotin.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Takeshi Endo, Ken Kadoya, Tomoaki Suzuki, Yuki Suzuki, Mohamad Alaa Terkawi, Daisuke Kawamura, Norimasa Iwasaki
Summary: The study demonstrated that mature SCs, especially RSCs, are capable of inducing axon regeneration, while developing SCs lack this ability. Furthermore, RSCs, but not SCPs, promoted neurite outgrowth of adult neurons, with distinct gene expression profiles between RSCs and SCPs. These findings suggest that RSC may be a promising candidate for regenerative cell therapy for PNI.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Neurosciences
Xingyu Liu, Federico D'Oleire Uquillas, Angela N. Viaene, Zonglei Zhen, Jesse Gomez
Summary: This study reveals the organization and functional properties of the human cerebellum during development, showing a tissue gradient across different lobules and a close relationship between cerebellar structural development and functional changes.
NATURE NEUROSCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Kathy D. McCoy, Markus B. Geuking
Summary: The gut microbiota can enhance cancer therapy by regulating immune responses, while specific gut bacteria can reprogram the innate immune tumor microenvironment to improve the efficacy of cancer treatments.
Article
Medicine, Research & Experimental
Yoshinori Matsumoto, Ioannis D. Dimitriou, Jose La Rose, Melissa Lim, Susan Camilleri, Napoleon Law, Hibret A. Adissu, Jiefei Tong, Michael F. Moran, Andrzej Chruscinski, Fang He, Yosuke Asano, Takayuki Katsuyama, Ken-Ei Sada, Jun Wada, Robert Rottapel
Summary: This study demonstrates that tankyrase negatively regulates TLR2 signaling, and its deficiency leads to systemic inflammation and elevated inflammatory cytokine production. Mechanistically, tankyrase deficiency results in tyrosine phosphorylation and activation of TLR2, which relies on the kinases SRC and SYK. Additionally, the observed inflammation and cytokine production in the absence of tankyrase are dependent on the adaptor protein 3BP2.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Editorial Material
Oncology
Jason A. Willis, Michael J. Overman
Summary: The study demonstrates the potential of inducing hypermutability using temozolomide as a pathway for a productive anti-PD-1 immune response in MMRp colorectal cancer.
Article
Chemistry, Multidisciplinary
Noureddine Boumdouha, Zitouni Safidine, Achraf Boudiaf
Summary: This paper presents a technique for generating and analyzing filled polyurethane foams and evaluating the characteristics of nonlethal projectiles. The study shows that the filling content does not affect the cell size of the polyurethane foam. Dynamic mechanical analysis and X-ray diffraction analysis are used to assess the properties of nonlethal projectiles.
Article
Biochemistry & Molecular Biology
Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M. Falcon, Mohammad Haneef, David R. Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer, Costas A. Lyssiotis, Yatrik M. Shah, Henry C. Lin, Hui-kuan Lin, Xiang Xue
Summary: Excess iron promotes glycolysis and colon tumor growth through the inhibition of the PDH complex function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Thermodynamics
Y. Zhao, Z. Yan, H. Zhang, C. Yang, P. Cheng
Summary: This study presents a hierarchically structured surface that can significantly reduce frost coverage and promote rapid removal of frost melts, opening up new possibilities for surface engineering in developing economic and scalable anti-/de-frosting surfaces.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
