Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

Hybridization Chain Reaction Amplification of MicroRNA Detection with a Tetrahedral DNA Nanostructure-Based Electrochemical Biosensor

(2014) Zhilei Ge et al.   ANALYTICAL CHEMISTRY

An Automated High-Throughput Counting Method for Screening Circulating Tumor Cells in Peripheral Blood

(2013) Mengxia Zhao et al.   ANALYTICAL CHEMISTRY

Direct Detection of Bacterial Genomic DNA at Sub-Femtomolar Concentrations Using Single Molecule Arrays

(2013) Linan Song et al.   ANALYTICAL CHEMISTRY

Mechanistic Evaluation of the Pros and Cons of Digital RT-LAMP for HIV-1 Viral Load Quantification on a Microfluidic Device and Improved Efficiency via a Two-Step Digital Protocol

(2013) Bing Sun et al.   ANALYTICAL CHEMISTRY

Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements

(2013) David A. Selck et al.   ANALYTICAL CHEMISTRY

A portable, pressure driven, room temperature nucleic acid extraction and storage system for point of care molecular diagnostics

(2013) Samantha Byrnes et al.   Analytical Methods

Efficient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High-Pore-Density Filter

(2013) Hun Joo Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma

(2013) Sanna Neselius et al.   BRAIN INJURY

Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries that Facilitate Nanotechnology

(2013) Kim E. Sapsford et al.   CHEMICAL REVIEWS

A negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cells

(2013) Benjamin P. Casavant et al.   METHODS

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

Highly Precise Measurement of HIV DNA by Droplet Digital PCR

(2013) Matthew C. Strain et al.   PLoS One

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Inertial Focusing for Tumor Antigen-Dependent and -Independent Sorting of Rare Circulating Tumor Cells

(2013) E. Ozkumur et al.   Science Translational Medicine

The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis

(2013) L. Zhang et al.   Science Translational Medicine

Plasma tau levels in Alzheimer's disease

(2013) Henrik Zetterberg et al.   Alzheimers Research & Therapy

Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples

(2012) Ivaylo Ivanov et al.   ANALYTICAL CHEMISTRY

Multiplexed Nanoflares: mRNA Detection in Live Cells

(2012) Andrew E. Prigodich et al.   ANALYTICAL CHEMISTRY

Charge Transport within a Three-Dimensional DNA Nanostructure Framework

(2012) Na Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simple diffusion-constrained immunoassay for p24 protein with the sensitivity of nucleic acid amplification for detecting acute HIV infection

(2012) Lei Chang et al.   JOURNAL OF VIROLOGICAL METHODS

Digital LAMP in a sample self-digitization (SD) chip

(2012) Alexander Gansen et al.   LAB ON A CHIP

Non-invasive prenatal measurement of the fetal genome

(2012) H. Christina Fan et al.   NATURE

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

An ultrasensitive universal detector based on neutralizer displacement

(2012) Jagotamoy Das et al.   Nature Chemistry

Digital PCR hits its stride

(2012) Monya Baker   NATURE METHODS

Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

(2012) Brian J. Kirby et al.   PLoS One

Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: Results of a pilot study

(2012) Jeffrey Randall et al.   RESUSCITATION

Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector

(2012) D. Issadore et al.   Science Translational Medicine

Androgen Receptor Signaling in Circulating Tumor Cells as a Marker of Hormonally Responsive Prostate Cancer

(2012) David T. Miyamoto et al.   Cancer Discovery

Point-of-Care Testing for Infectious Diseases: Diversity, Complexity, and Barriers in Low- And Middle-Income Countries

(2012) Nitika Pant Pai et al.   PLOS MEDICINE

Hierarchical Nanotextured Microelectrodes Overcome the Molecular Transport Barrier To Achieve Rapid, Direct Bacterial Detection

(2011) Leyla Soleymani et al.   ACS Nano

Polymerase Chain Reaction-Free, Sample-to-Answer Bacterial Detection in 30 Minutes with Integrated Cell Lysis

(2011) Brian Lam et al.   ANALYTICAL CHEMISTRY

DNA Nanostructure-Decorated Surfaces for Enhanced Aptamer-Target Binding and Electrochemical Cocaine Sensors

(2011) Yanli Wen et al.   ANALYTICAL CHEMISTRY

Direct Genetic Analysis of Ten Cancer Cells: Tuning Sensor Structure and Molecular Probe Design for Efficient mRNA Capture

(2011) Elizaveta Vasilyeva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clinical evaluation of a novel method for the measurement of prostate-specific antigen, AccuPSATM, as a predictor of 5-year biochemical recurrence-free survival after radical prostatectomy: results of a pilot study

(2011) Herbert Lepor et al.   BJU INTERNATIONAL

Metagenomics and Personalized Medicine

(2011) Herbert W. Virgin et al.   CELL

Regenerable electrochemical immunological sensing at DNA nanostructure-decorated gold surfaces

(2011) Hao Pei et al.   CHEMICAL COMMUNICATIONS

Single molecule measurements of tumor necrosis factor α and interleukin-6 in the plasma of patients with Crohn's disease

(2011) Linan Song et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Molecular Methods and Platforms for Infectious Diseases Testing

(2011) Rajyasree Emmadi et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Multiplexed Quantification of Nucleic Acids with Large Dynamic Range Using Multivolume Digital RT-PCR on a Rotational SlipChip Tested with HIV and Hepatitis C Viral Load

(2011) Feng Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Digital PCR provides absolute quantitation of viral load for an occult RNA virus

(2011) Richard Allen White et al.   JOURNAL OF VIROLOGICAL METHODS

Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay

(2011) Hyun-Gyung Goh et al.   LEUKEMIA & LYMPHOMA

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

(2011) Yu Xiang et al.   Nature Chemistry

Megapixel digital PCR

(2011) Kevin A Heyries et al.   NATURE METHODS

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

(2011) Henrik Zetterberg et al.   PLoS One

Point-of-care nucleic acid testing for infectious diseases

(2011) Angelika Niemz et al.   TRENDS IN BIOTECHNOLOGY

Target-Responsive Structural Switching for Nucleic Acid-Based Sensors

(2010) Di Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing

(2010) Hao Pei et al.   ADVANCED MATERIALS

Nanostructuring of Sensors Determines the Efficiency of Biomolecular Capture

(2010) Xiaomin Bin et al.   ANALYTICAL CHEMISTRY

Size-Selective Microcavity Array for Rapid and Efficient Detection of Circulating Tumor Cells

(2010) Masahito Hosokawa et al.   ANALYTICAL CHEMISTRY

The Effect of Rapid Screening for Methicillin-Resistant Staphylococcus aureus (MRSA) on the Identification and Earlier Isolation of MRSA-Positive Patients

(2010) Eilish Creamer et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Deformability considerations in filtration of biological cells

(2010) Jason S. Kuo et al.   LAB ON A CHIP

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

(2010) David M Rissin et al.   NATURE BIOTECHNOLOGY

Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

(2010) S. L. Stott et al.   Science Translational Medicine

Direct Profiling of Cancer Biomarkers in Tumor Tissue Using a Multiplexed Nanostructured Microelectrode Integrated Circuit

(2009) Zhichao Fang et al.   ACS Nano

The Role Radius of Curvature Plays in Thiolated Oligonucleotide Loading on Gold Nanoparticles

(2009) Haley D. Hill et al.   ACS Nano

Direct, Electronic MicroRNA Detection for the Rapid Determination of Differential Expression Profiles

(2009) Hong Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming the detection limits of biosensors through controlled nanostructuring

(2009) Leyla Soleymani et al.   Nature Nanotechnology

Nanoparticle-based bio-barcode assay redefines "undetectable" PSA and biochemical recurrence after radical prostatectomy

(2009) C. S. Thaxton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organophosphonate-Based PNA-Functionalization of Silicon Nanowires for Label-Free DNA Detection

(2008) Anna Cattani-Scholz et al.   ACS Nano

Detection of Single-Molecule DNA Hybridization Using Enzymatic Amplification in an Array of Femtoliter-Sized Reaction Vessels

(2008) Zhaohui Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of HIV-1 p24 Gag in plasma by a nanoparticle-based bio-barcode-amplification method

(2008) Eun-Young Kim et al.   Nanomedicine

Making it stick: convection, reaction and diffusion in surface-based biosensors

(2008) Todd M Squires et al.   NATURE BIOTECHNOLOGY

Studying copy number variations using a nanofluidic platform

(2008) Jian Qin et al.   NUCLEIC ACIDS RESEARCH