Channelrhodopsin engineering and exploration of new optogenetic tools

Using light to control signaling cascades in live neurons

(2010) Anshul Rana et al.   CURRENT OPINION IN NEUROBIOLOGY

The Branched Photocycle of the Slow-Cycling Channelrhodopsin-2 Mutant C128T

(2010) Katja Stehfest et al.   JOURNAL OF MOLECULAR BIOLOGY

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Engineered photoreceptors as novel optogenetic tools

(2010) Andreas Möglich et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Opto-Current-Clamp Actuation of Cortical Neurons Using a Strategically Designed Channelrhodopsin

(2010) Lei Wen et al.   PLoS One

Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics

(2009) John Y. Lin et al.   BIOPHYSICAL JOURNAL

The retinal structure of channelrhodopsin-2 assessed by resonance Raman spectroscopy

(2009) Melanie Nack et al.   FEBS LETTERS

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Monitoring Light-induced Structural Changes of Channelrhodopsin-2 by UV-visible and Fourier Transform Infrared Spectroscopy

(2008) Eglof Ritter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Signaling Mechanism of Light-Regulated Histidine Kinases

(2008) Andreas Möglich et al.   JOURNAL OF MOLECULAR BIOLOGY

Light-activated DNA binding in a designed allosteric protein

(2008) D. Strickland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA