Editorial Material
Hematology
Jane A. Little
Summary: Researchers cleverly improve red blood cell health in sickle cell disease patients by activating the enzyme PK in the glycolytic pathway, which reduces the concentration of 2,3-DPG and increases the oxygen affinity of HbS.
Article
Engineering, Biomedical
Zhengyang Yang, Huanhuan Chen, Peizheng Yang, Xiaofei Shen, Yiqiao Hu, Yuhao Cheng, Hongwei Yao, Zhongtao Zhang
Summary: This study reports a technique to deliver dissolved oxygen locally into wound surface by adding lyophilized oxygen encapsulated nanoparticles to traditional gel-based wound dressings. The results show that this technique has therapeutic effects on hypoxic cells in vitro and on open wounds and diabetic mice models. With its biocompatibility, effectiveness and practicality, this hydrogel has significant transformation value in caring for and accelerating the healing of various clinical wounds, especially chronic wounds.
Article
Dermatology
Dimitri Beeckman, Matthew Cooper, Emily Greenstein, Patricia Idensohn, Robert J. Klein, Norbert Kolbig, Kimberly Leblanc, Catherine Milne, Terry Treadwell, Dot Weir, Wendy White
Summary: Many community-based healthcare providers without specialized training in wound care are responsible for managing various types of wounds. Failure to recognize and address issues that cause delayed wound healing can lead to increased costs and suffering. To encourage early intervention, a panel of wound care experts developed evidence-based recommendations for community-based healthcare providers to identify and treat hard-to-heal wounds.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, Research & Experimental
Preety Sharma, Arun Kumar, Asmita Deka Dey, Tapan Behl, Swati Chadha
Summary: The complex process of wound healing involves cell migration, proliferation, extracellular matrix deposition, and remodeling. Encapsulation of growth factors and stem cells can accelerate healing and enhance skin regeneration. Research shows the essential role of growth factors in wound healing and the potential of nanotechnology-based approaches for delivering these factors effectively.
Editorial Material
Clinical Neurology
Daniel B. Rubin, Angelique C. Paulk
Summary: This commentary discusses a study on the volitional control of individual neurons in the human brain conducted by Patel et al.
Article
Medicine, Research & Experimental
Rahimeh B. Atashgah, Amir Ghasemi, Mohammad Raoufi, Mohammad-Amin Abdollahifar, Steven Zanganeh, Hossein Nejadnik, Alieh Abdollahi, Shahriar Sharifi, Baltazar Lea, Miguel Cuerva, Mehdi Akbarzadeh, Carmen Alvarez-Lorenzo, Seyed Nasser Ostad, Andrea S. Theus, Doris L. LaRock, Christopher N. LaRock, Vahid Serpooshan, Rouzbeh Sarrafi, Ki-Bum Lee, Hojatollah Vali, Holger Schoenherr, Lisa Gould, Pablo Taboada, Morteza Mahmoudi
Summary: A multifunctional wound dressing has been developed by the research team to target multiple challenges in wound healing, accelerating the healing process and representing a promising alternative to current products.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Xinyi Lv, Yan Xu, Xiaohong Ruan, Dongliang Yang, Jinjun Shao, Yanling Hu, Wenjun Wang, Yu Cai, Yuexing Tu, Xiaochen Dong
Summary: An injectable, degradable, and photoactivated antibacterial hydrogel (MPDA-BNN6@Gel) was developed for the treatment of infected wounds. The hydrogel could generate local hyperthermia and release large quantities of NO gas to treat the infection under laser irradiation. It was found that the hydrogel eradicated bacteria by damaging the cell membrane, genetic metabolism, and material energy. Additionally, the hydrogel promoted wound healing in vivo in the absence of laser irradiation.
ACTA BIOMATERIALIA
(2022)
Article
Infectious Diseases
Renan Aparecido Fernandes Scappaticci, Andresa Aparecida Berretta, Elina Cassia Torres, Andrei Felipe Moreira Buszinski, Gabriela Lopes Fernandes, Thaila Fernanda dos Reis, Francisco Nunes de Souza-Neto, Luiz Fernando Gorup, Emerson Rodrigues de Camargo, Debora Barros Barbosa
Summary: The study found that both silver nanoparticles showed significant improvement in wound healing within the first 7 days of treatment. After 14 days, all treatments were superior to controls and significantly reduced the amount of S. aureus. CS exhibited better anti-inflammatory results, while GS and CS had the highest number of fibroblasts.
Article
Biochemistry & Molecular Biology
Omidreza Raei Abbasabadi, Mohammad Reza Farahpour, Zohreh Ghazi Tabatabaei
Summary: This study investigated the effects of ointments made from ZnO/Chsn/Citl nanoparticles (NPs) in treating infected wounds. The results showed that these nanoparticles exhibited good antibacterial activity and could accelerate wound healing. Compared to the commercial ointment mupirocin, these ointments have the potential to be an alternative for treating infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Maryam Rezvani, Maria Letizia Manca, Aldo Muntoni, Giorgia De Gioannis, Jose Luis Pedraz, Gemma Gutierrez, Maria Matos, Anna Maria Fadda, Maria Manconi
Summary: This study developed whey vesicles loaded with gingerol by using an eco-friendly method, which showed promising effects in protecting intestinal cells and promoting wound healing. Whey vesicles prepared with tragacanth gum demonstrated the highest capability in intestinal protection, highlighting their potential in nanomedicine applications for treating intestinal damages.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Michael G. Monaghan, Rajiv Borah, Charlotte Thomsen, Shane Browne
Summary: Diabetic foot ulcers (DFUs) are a severe complication that can lead to limb amputation. The presence of unresolved inflammation in the DFU microenvironment is a key factor contributing to the non-healing nature of DFUs. Therefore, controlling and modulating the inflammatory response is crucial for the treatment of DFUs.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Dermatology
Vladica Velickovic, Dina Jankovic
Summary: This paper discusses the sources of uncertainty in the evaluation of the holistic approach to managing hard-to-heal wounds. The authors identify the heterogeneity in aetiology and patient populations, heterogeneity in treatment pathways, and challenges in capturing all relevant outcomes as key sources of uncertainty. They propose the use of sophisticated modeling techniques such as scenario and sensitivity analyses to adequately address these complexities.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Hanna Linnea Wickstrom, Cecilia Fagerstrom, Rut Frank Oien, Peter Anderberg, Patrik Midlov
Summary: This study investigated the differences in antibiotic prescription for patients with hard-to-heal ulcers using a digital decision support system (DDSS) compared to those without using DDSS. The results showed that patients assessed using DDSS had significantly lower antibiotic prescription rates, and diabetes, long healing time, and different types of ulcers were predictors for antibiotic prescription.
Article
Polymer Science
Patrik Stenlund, Linnea Enstedt, Karin Margaretha Gilljam, Simon Standoft, Astrid Ahlinder, Maria Lundin Johnson, Henrik Lund, Anna Millqvist Fureby, Mattias Berglin
Summary: Current standard wound care lacks dressings that actively promote healing and is costly. In this study, we developed an environmentally friendly 3D printed bioactive hydrogel-based wound dressing suitable for hard-to-heal wounds. The dressing, composed of renewable marine components including heat-treated salmon roe extract, alginate, and nanocellulose, showed enhanced wound healing properties. The dressing was successfully tested on burn wounds and demonstrated accelerated wound closure and reduced inflammation.
Review
Medicine, General & Internal
Michael Burnet, Daniel G. Metcalf, Scarlet Milo, Clemens Gamerith, Andrea Heinzle, Eva Sigl, Kornelia Eitel, Marieke Haalboom, Philip G. Bowler
Summary: Traditionally, wound infection is defined by clinical signs and microbiological analysis. However, these approaches have limitations, especially in early or complex wounds. Patient-derived biomarkers of immune activation may indicate wound infection earlier and more reliably. Detection of innate immune cell enzymes offers a new, simple, and effective approach to determine wound infection status, enhancing infection resolution and wound healing.
