Article
Pharmacology & Pharmacy
Naeem Sheik Abdul, Jeanine L. Marnewick
Summary: This study investigates the effects of FB1 on mitochondrial toxicity and its implications in cultured human liver cells. The results reveal that FB1 disrupts the stability of the mitochondrial electron transport chain, leading to dysregulated energy metabolism. It also activates p53, a transcription factor that induces the expression of lincRNA-p21, which further stabilizes HIF-1 alpha. These findings provide important insights into the mechanisms of FB1's tumor promoting effects.
Article
Pharmacology & Pharmacy
Xiao-Na Li, San-Qiao Yang, Min Li, Xue-Song Li, Qing Tian, Fan Xiao, Yi-Yun Tang, Xuan Kang, Chun-Yan Wang, Wei Zou, Ping Zhang, Xiao-Qing Tang
Summary: The study revealed that formaldehyde-induced neurotoxicity may involve ferroptosis and the Warburg effect. Inhibition of the Warburg effect can protect neurons from ferroptosis and cell death.
Article
Oncology
Yin Yuan, Shuo Ni, Aoxiang Zhuge, Bo Li, Lanjuan Li
Summary: Iron plays a dual role in cancer development, promoting cell proliferation while inducing cell death. Research has shown that iron can enhance the Warburg effect of colorectal cancer cells, suppress sensitivity to ferroptosis, and promote tumorigenesis by inducing reactive oxygen species and activating NRF2. Therefore, iron elimination or a low-iron diet may be valid therapeutic approaches for colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Quan Zhao, Lina Wang, Zongwei Lv, Xia Wang, Zhenqun Xu, Kefeng Wang
Summary: This study analyzed the global research status of the Warburg effect in cancer using bibliometrics. The findings showed an overall increase in annual publications over the past decade, with China being the most productive country and the United States receiving the most citations. Lactate metabolism, citrate production, and non-coding RNAs related to the Warburg effect received increasing attention in cancer research.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
D. Grahame Hardie
Summary: Otto Warburg published the first paper on the Warburg effect in 1923, revealing the difference in lactate production between tumor tissues and normal tissues in glucose metabolism. However, the mechanisms underlying the Warburg effect are still not fully understood to this day.
ENDOCRINE-RELATED CANCER
(2022)
Article
Pharmacology & Pharmacy
Fan Chen, Junnan Liao, Pinghui Wu, Li Cheng, Yingchao Ma, Linghan Zhang, Xiaomin Leng, Xiuzhi Zhu, Zhiping Liu, Fuhua Xie
Summary: Our study first shows that ORI could have anticancer activity by inhibiting the Warburg effect as a novel activator of PKM2.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Zuolei Jing, Qianmei Liu, Xinyuan He, Zhirong Jia, Zhizhong Xu, Bolin Yang, Ping Liu
Summary: Our study demonstrates that NCAPD3 promotes glucose metabolism reprogramming and enhances the Warburg effect in colorectal tumorigenesis and CRC progression. We found that NCAPD3 is overexpressed in CRC tissues and is associated with poor prognosis in CRC patients. Knockout of NCAPD3 suppressed CRC development in mouse models and we identified the underlying molecular mechanism by which NCAPD3 regulates glucose metabolism.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Zsuzsanna Gaal
Summary: MicroRNAs play a crucial role in the initiation, progression, and metastasis of cancer, interacting closely with oncogenes, tumor-suppressor genes, and epigenetic modifiers. Understanding reversible epigenetic and metabolic alterations has opened new horizons in the personalized treatment of cancer.
Article
Medicine, Research & Experimental
Kateryna Tarhonska, Beata Janasik, Joanna Roszak, Kornelia Kowalczyk, Monika Lesicka, Edyta Reszka, Edyta Wieczorek, Marcin Braun, Agnieszka Kolacinska-Wow, Jaroslaw Skokowski, Leszek Kalinowski, Ewa Jablonska
Summary: The association between cadmium and the Warburg effect in breast cancer was suggested by an observational study, although not confirmed in vitro. However, cadmium seems to interfere with tamoxifen treatment, which deserves further investigation in terms of its possible implication in intrinsic resistance to hormone therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Zhikun Li, Mei Geng, Xiaojian Ye, Yunhan Ji, Yifan Li, Xiangyang Zhang, Wei Xu
Summary: This study reveals that IRF7 is downregulated in osteosarcoma and its higher expression is associated with a better survival prognosis. IRF7 plays critical roles in suppressing aerobic glycolysis in osteosarcoma cells through inhibition of PKM2 expression, making it a potential therapeutic target for osteosarcoma patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
M. Martins Pinto, P. Paumard, C. Bouchez, S. Ransac, S. Duvezin-Caubet, J. P. Mazata, M. Rigouleta, A. Devina
Summary: Cancer cells exhibit altered energy metabolism, with decreased respiration and increased glycolysis compared to normal cells. This phenomenon, known as the Warburg effect, suggests that cancer cells mainly rely on fermentative metabolism for ATP generation. The mechanisms and implications of this metabolic shift are still a topic of debate. Understanding how cancer cells regulate their energy metabolism pathways and how this metabolism affects cell proliferation is crucial for unraveling the mechanisms of cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Article
Biochemistry & Molecular Biology
Karolina Jurkowska, Beata Szymanska, Brygida Knysz, Agnieszka Piwowar
Summary: This study investigated the connection between cART and the expression of SIRT1, SIRT3, and SIRT6 in HIV-infected men. The results showed that SIRT6 had the most significant changes during HIV infection, and the type of cART also had an influence on the level of SIRT1.
Review
Oncology
Xinyang Zhong, Xuefeng He, Yaxian Wang, Zijuan Hu, Huixia Huang, Senlin Zhao, Ping Wei, Dawei Li
Summary: Colorectal cancer is a common and deadly cancer, and the Warburg effect plays a significant role in promoting cancer metastasis and altering the tumor microenvironment. Understanding the mechanisms of the Warburg effect in colorectal cancer and identifying new therapeutic targets is a promising approach.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Engineering, Biomedical
Li Sun, Yuqing Liu, Nanyan Yang, Xiandong Ye, Zhihong Liu, Jingjing Wu, Minyu Zhou, Wen Zhong, Meiwen Cao, Junhao Zhang, Kibret Mequanint, Malcolm Xing, Wangjun Liao
Summary: Gold nanoparticles (AuNPs) directly target glycolysis and energy supply, inhibiting tumor growth. These findings provide new strategies for designing nano-based medicines and anti-glycolytic therapies.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Hyunkoo Kang, Byeongsoo Kim, Junhyeong Park, HyeSook Youn, BuHyun Youn
Summary: The paper reviews the role of the Warburg effect in redox homeostasis, DNA damage repair, and radioresistance. It highlights the significance of metabolism in tumor recurrence and summarizes radiosensitizing drugs targeting the Warburg effect.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
