Editorial Material
Hematology
Kaosheng Lv, Wei Tong
Summary: In this study, Zhao et al found that downregulation of MS4A3 contributes to the persistence, progression, and drug resistance of chronic myeloid leukemia (CML) to the BCR-ABL inhibitor imatinib. Thus, enhancing MS4A3 levels could be a potential therapeutic strategy in treating CML.
Article
Biochemistry & Molecular Biology
Pietro Cacialli, Marie-Pierre Mailhe, Ingrid Wagner, Doron Merkler, Rachel Golub, Julien Y. Bertrand
Summary: This study reveals that the expansion of hematopoietic stem cells during vertebrate development is a result of the sequential and synergistic contribution of neutrophils, macrophages, and endothelial cells.
Article
Medicine, General & Internal
Alessandra Oliva, Emanuele Rando, Dania Al Ismail, Massimiliano De Angelis, Francesca Cancelli, Maria Claudia Miele, Raissa Aronica, Vera Mauro, Federica Di Timoteo, Lorenzo Loffredo, Claudio M. Mastroianni
Summary: This study compared sE-selectin levels in COVID-19 patients and found that higher levels were associated with increased risk of ICU admission, potentially serving as a predictor for disease severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Arduino A. Mangoni
Summary: Statins can effectively decrease circulating levels of cell adhesion molecules, including P-selectin, L-selectin, and E-selectin, which are involved in the pathogenesis of atherosclerosis. Research indicates that statins have a significant impact on reducing these selectins independently of baseline lipid profiles and other patient characteristics, potentially contributing to cardiovascular risk reduction.
Article
Biochemical Research Methods
Yusuke Himeoka, Namiko Mitarai
Summary: Bacteria need to evolve an optimal waking up strategy in response to fluctuating environmental stresses, such as alternate periods of growth and starvation. Prolonged lag time induced by starvation contributes to antibiotic tolerance. The optimal lag time shows a discontinuous transition when the severity of antibiotic application increases, suggesting controlled antibiotic usage can reduce tolerant bacteria.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Hepatic fibrosis caused by various etiologies is a high worldwide burden with no effective cure except for liver transplantation. Recent research has shown significant progress in developing drugs targeting different targets for the treatment of hepatic fibrosis. However, many clinical trials have shown poor results, and the potential of natural products in treating hepatic fibrosis is still not widely recognized. Combination therapy targeting multiple targets may be the current approach for treating hepatic fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Yu Kinoshita, Osamu Itani, Yuichiro Otsuka, Yuuki Matsumoto, Sachi Nakagome, Yoneatsu Osaki, Susumu Higuchi, Jike Maki, Hideyuki Kanda, Yoshitaka Kaneita
Summary: The study aimed to determine the prevalence and risk factors of difficulty waking up among adolescents. Results showed that factors such as no participation in club activities, early-morning-awakening, feeling bad throughout a morning, drinking, and smoking were significantly associated with school tardiness/absence, indicating potential underlying diseases.
Article
Clinical Neurology
Yu Kinoshita, Osamu Itani, Yuichiro Otsuka, Yuuki Matsumoto, Sachi Nakagome, Yoneatsu Osaki, Susumu Higuchi, Jike Maki, Hideyuki Kanda, Yoshitaka Kaneita
Summary: The study found that risk factors for difficulty waking up among adolescents include sleep status, lifestyle, and mental health. There are different prevalence rates between genders and grades, with factors such as non-participation in club activities, smoking, and drinking potentially leading to tardiness and absence.
Article
Medicine, General & Internal
Noriyuki Konishi, Hajime Kumagai, Hiroyuki Sawatari, Tetsuro Hoshino, Yoko Murase, Maiko Yamaguchi, Ayako Urabe, Yuka Kiyohara, Aki Arita, Masayo Baku, Ryujiro Sasanabe, Toshiaki Shiomi
Summary: School non-attendance due to difficulties waking up is increasing in Japan, and this study found that a combination therapy involving sleep hygiene guidance, low-dose aripiprazole administration, and blue-light exposure was effective in improving wake-up difficulties and mental quality of life in non-school-attending teenage students.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Anesthesiology
Eric S. Schwenk, Rajnish K. Gupta
Summary: This prospective cohort study found that immediate moderate to severe pain after surgery remains a challenge. Risk factors for higher pain levels include female sex, younger age, preoperative pain, daily opioid use, and major surgical procedures. Additionally, postoperative nausea and vomiting occurred in only 5% of cases, with female sex being a significant risk factor again.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Li Chen, Desong Kong, Siwei Xia, Feixia Wang, Zhanghao Li, Feng Zhang, Shizhong Zheng
Summary: Liver fibrosis is a repair process of chronic liver injuries, and its progression relies on the activation of hepatic stellate cells and remodeling of the extracellular matrix. Liver fibrosis can lead to liver dysfunction and hepatocellular carcinoma. Innate immune cells and autophagy play complex roles in liver fibrosis. Further research on these roles is crucial for the prevention and treatment of liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Girija Naidoo, Olive P. Khaliq, Jagidesa Moodley, Thajasvarie Naicker
Summary: This study found that serum sE-selectin levels were significantly elevated in HIV-negative women with preeclampsia compared to those with normal pregnancies. There were statistical differences in gestational age, blood pressure, and baby weight across the study groups.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Cell Biology
Quanming An, Yong Dong, Yang Cao, Xu Pan, Yuan Xue, Ya Zhou, Yonggang Zhang, Feng Ma
Summary: The MYH9 gene plays a critical role in normal hematopoiesis, and its deletion leads to severe hematopoietic defects and early lethality in mice.
Article
Medicine, Research & Experimental
Nopmullee Tanhuad, Umnuaychoke Thongsa-Ad, Nareerat Sutjarit, Ploychompoo Yoosabai, Wittaya Panvongsa, Sirapope Wongniam, Apichart Suksamrarn, Pawinee Piyachaturawat, Usanarat Anurathapan, Suparerk Borwornpinyo, Arthit Chairoungdua, Suradej Hongeng, Kanit Bhukhai
Summary: The use of ASPP 049 has been shown to significantly increase the number of adult CD34+ cells and improve their functional properties, thus enhancing the ex vivo culture of hematopoietic stem cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Yilei Deng, Jian Li, Menghao Zhou, Zhiwei Liang, Longshuan Zhao
Summary: In liver fibrosis, the up-regulation of c-Myc and KCNQ1OT1 was observed. Inhibiting c-Myc led to a decrease in KCNQ1OT1 expression, thereby blocking HSC proliferation and EMT, ultimately suppressing the progression of liver fibrosis.
DIGESTIVE AND LIVER DISEASE
(2021)
