Journal
NATURE MEDICINE
Volume 18, Issue 12, Pages 1742-1743Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.3011
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Hydrocephalus describes an expansion of the cerebral ventricles that is associated with decreased cerebral volume and compromised neurological function. Although hydrocephalus mostly occurs sporadically, it is frequently associated with diseases caused by defective cilia function, including Bardet-Biedl syndrome (BBS). A new study reveals that hydrocephalus in a mouse model of BBS is related to defective proliferation and apoptosis of neural progenitor cells (NPCs) and can be rescued with lithium treatment (pages 1797-1804).
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