Article
Multidisciplinary Sciences
Milan Riha, Karl O. Gjelland, Vilem Ded, Antti P. Eloranta, Ruben Rabaneda-Bueno, Henrik Baktoft, Lukas Vejrik, Ivana Vejrikova, Vladislav Drastik, Marek Smejkal, Michaela Holubova, Tomas Juza, Carolyn Rosten, Zuzana Sajdlova, Finn Okland, Jiri Peterka
Summary: Our study found that differences in structural complexity in lakes lead to significant changes in the foraging behavior of an apex predator, the Northern pike. The pike in the low structural complexity lake displayed increased activity, space use, and growth, while the pike in the high structural complexity lake showed behavior consistent with ambush predation. This could have implications for the prey community in these lakes.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Carla Caddeo, Morena Gabriele, Amparo Nacher, Xavier Fernandez-Busquets, Donatella Valenti, Anna Maria Fadda, Laura Pucci, Maria Manconi
Summary: The study developed Eudragit-coated liposomes for safe transportation of resveratrol and artemisinin through the gastrointestinal tract to target the intestine, exhibiting anti-tumor effects. Results showed that these liposomes could induce significant cell death in intestinal adenocarcinoma cells, thereby inhibiting intestinal tumor growth.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Anamika Singh, Isaiah T. Arkin
Summary: This study demonstrates the potential of targeting viral ion channels as a treatment strategy to enhance and complement our antiviral arsenal against COVID-19. In cell-based experiments, several ion channel blockers exhibited antiviral activity, and there was synergism between certain blockers. These findings are significant for further pandemic control and development of treatment options.
Article
Immunology
Jennifer Currenti, Becker M. P. Law, Kai Qin, Mina John, Mark A. Pilkinton, Anju Bansal, Shay Leary, Ramesh Ram, Abha Chopra, Rama Gangula, Ling Yue, Christian Warren, Louise Barnett, Eric Alves, Wyatt J. McDonnell, Anuradha Sooda, Sonya L. Heath, Simon Mallal, Paul Goepfert, Spyros A. Kalams, Silvana Gaudieri
Summary: Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another adaptation strategy, involving the selection of mutations within epitopes that retain immune recognition despite immune pressure, is less understood. This strategy may modulate the transcriptome of CD8(+) T cells and potentially select for less effective T cell clones over time.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Marjon Zamani, James M. Robson, Andy Fan, Michael S. Bono, Ariel L. Furst, Catherine M. Klapperich
Summary: Sexually transmitted infections, such as HIV and HPV, have a disproportionate impact on low-resource settings. Early diagnosis is crucial for managing HIV and preventing HPV-induced cervical cancer. A novel electrochemical platform combined with loop-mediated isothermal amplification and CRISPR-based detection shows promise for rapidly and cost-effectively detecting viral infections.
ACS CENTRAL SCIENCE
(2021)
Review
Virology
Varada Anirudhan, Hyun Lee, Han Cheng, Laura Cooper, Lijun Rong
Summary: The review provides information on potential treatment strategies for COVID-19 that target the essential proteins of the virus, specifically 3CL(pro) and PLpro, which are key in inhibiting viral replication and may offer insights from previous experience with SARS-CoV.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Medicine, Research & Experimental
Mengmeng Liu, Lina Liu, Yongping Song, Wei Li, Linping Xu
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment, affecting tumor development and treatment outcomes. Therapeutic strategies targeting TAMs include depletion of TAMs, inhibition of TAM recruitment, modulation of TAM phagocytic activity, and reprogramming TAMs to enhance their anti-tumor capacity. Chimeric antigen receptor macrophages (CAR-Ms) have emerged as a promising approach for solid tumor immunotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Jun Li, Ziao Zhou, Xiangmei Liu, Yufeng Zheng, Changyi Li, Zhenduo Cui, Kelvin Wai Kwok Yeung, Hongbo Zhou, Jiahui Zou, Zhaoyang Li, Shengli Zhu, Yanqin Liang, Xianbao Wang, Shuilin Wu
Summary: This study introduces a novel strategy of using herbal medicines as materials to enhance therapeutic effects, with the creation of natural tea nano-dots from catechins extracted from Chinese black tea. The antibacterial and antiviral mechanisms against MRSA and H1N1 were explored, showing excellent biosafety in piglets and better therapeutic outcomes in lethal H1N1-MRSA pneumonia.
Review
Medicine, General & Internal
Camille Peneau, Jessica Zucman-Rossi, Jean-Charles Nault
Summary: Virus-related liver carcinogenesis, including chronic hepatitis B and C infections, is a major contributor to cancer-related deaths worldwide. Mechanisms such as chronic inflammation and cirrhosis, viral insertional mutagenesis, and expression of oncogenic proteins play key roles in the oncogenic properties of HBV infection. Additionally, adeno associated virus type 2 (AAV2) insertion mutagenesis has been linked to the occurrence of HCC in non-cirrhotic patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yinghong Xiao, Peter Lidsky, Yuta Shirogane, Ranen Aviner, Chien-Ting Wu, Weiyi Li, Weihao Zheng, Dale Talbot, Adam Catching, Gilad Doitsh, Weiheng Su, Colby E. Gekko, Arabinda Nayak, Joel D. Ernst, Leonid Brodsky, Elia Brodsky, Elsa Rousseau, Sara Capponi, Simone Bianco, Robert Nakamura, Peter K. Jackson, Judith Frydman, Raul Andino
Summary: Researchers created an antiviral genome eTIP1 by deleting the capsid-coding region of poliovirus, showing significant therapeutic effects against RNA viruses. eTIP1 not only limits virus replication in the nasal cavity but also exerts a non-cell-autonomous antiviral action in the lungs through inducing interferon responses. Moreover, a single dose of eTIP1 not only protects animals from SARS-CoV-2 infection, but also stimulates antibody production for long-term protection.
Review
Virology
Josh G. Kim, Liang Shan
Summary: HIV-1 protease plays a critical role in the maturation of viral particles and can also cleave host cell proteins. The interaction between HIV-1 protease and CARD8 inflammasome is of particular interest, as recent studies have shown that CARD8 can sense the activity of HIV-1 protease and induce cell death. Premature activation of HIV-1 protease may be used as a strategy to target CARD8-mediated cell killing and eliminate latent reservoirs in people living with HIV.
Article
Business
Elisabeth Wolfsteiner, Reinhard Grohs, Heribert Reisinger
Summary: Official sport event sponsors can benefit from disclosing ambush marketing activities with negative communication frames, as it can lead to worse performance by ambush marketers and benefits for the sponsors. However, this disclosure is only effective if the information is highly accessible in consumers' mind.
JOURNAL OF BUSINESS RESEARCH
(2021)
Article
Chemistry, Analytical
W. Saisuk, C. Srisawat, S. Yoksan, T. Dharakul
Summary: A molecular beacon biosensor was developed for efficient detection of viral RNAs. The biosensor demonstrated high sensitivity and real-time detection, making it highly significant for point-of-care diagnostic applications for viral infectious diseases.
ANALYTICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Chih-Chieh Cheng, Eny Sofiyatun, Wei-June Chen, Lian-Chen Wang
Summary: Dengue fever is a mosquito-borne viral disease that is increasingly important globally, causing heavy burdens in tropical and subtropical regions. The virus alternately infects mosquito and human cells, leading to apoptosis in infected human cells but mostly survival in mosquito cells, which allows for efficient transmission. Various antioxidant genes and antiapoptotic processes play crucial roles in the ability of mosquito cells to survive DENV infection.
Review
Oncology
Anita Mahajan, Helen Shih, Marta Penas-Prado, Keith Ligon, Kenneth Aldape, Leland S. Hu, Ashlee R. Loughan, Michael R. Basso, Heather E. Leeper, Brian V. Nahed, Shannon L. Stott, Susan Geyer, Caterina Giannini, Evanthia Galanis
Summary: Medulloblastoma, the most common embryonal tumor in children, can also arise in older patients. Clinical studies have helped understand molecular pathways and improved treatment strategies. Recent research has identified at least four subtypes of medulloblastoma, each potentially benefitting from specific therapies.
