Article
Medicine, Research & Experimental
Qingqing Hou, Shiming Zhang, Yuan Li, Huanjun Wang, Dan Zhang, Dongmei Qi, Yunlun Li, Haiqiang Jiang
Summary: This study aimed to investigate the association of lipid metabolites, circadian genes, and lipid metabolism associated genes in spontaneously hypertensive rats. Through lipidomics and gene expression analysis, it was found that SHR exhibited significant differences in lipid metabolites levels compared to WKY, as well as disturbances in circadian and lipid metabolism associated gene expressions. Moreover, a strong association between the levels of lipid metabolites and circadian genes and lipid metabolism associated genes was identified.
Article
Microbiology
Michelle N. N. Vu, Vineet D. D. Menachery
Summary: SARS-CoV-2 has a pathogenicity closer to SARS-CoV and MERS-CoV, and a transmissibility similar to common cold coronaviruses. The features of the receptor-binding domain and protease cleavage of the spike protein enable SARS-CoV-2 to become a pandemic virus.
Editorial Material
Hematology
Daniel Thomas
Summary: Awada et al demonstrate the utility of artificial intelligence algorithms in predicting prognosis in acute myeloid leukemia by defining novel molecular groupings. This study highlights the expanding applications of machine learning in medicine.
Article
Agriculture, Dairy & Animal Science
Erika Gal, Laszlo Bartosiewicz
Summary: The researchers discovered eight animal remains with pathological changes in northern and western Hungary. They identified linear enamel hypoplasia for the first time in the Hungarian Neolithic. By comparing these Middle Neolithic finds with data from other prehistoric periods, they observed patterns in the distribution of pathological lesions. They also considered factors such as assemblage size, inter-observer bias, and changes in animal-keeping practices.
Article
Chemistry, Medicinal
Xialin Zhu, Qingqing Hou, Ling Zhang, Danyang Wang, Zhenhua Tian, Yuecheng Liu, Yu Wang, Yunlun Li, Haiqiang Jiang
Summary: Hypertension is a progressive metabolic disease characterized by circadian regulation of lipid metabolism disorder. This study found that isorhynchophylline (IRP) can improve lipid metabolism rhythm disorder by regulating specific genes, providing a potential treatment strategy for hypertension.
PHYTOTHERAPY RESEARCH
(2023)
Review
Medicine, General & Internal
Yu-Lu Liu, Si-Yi Gong, Shu-Ting Xia, Ya-Li Wang, Hao Peng, Yun Shen, Chun-Feng Liu
Summary: Light therapy (LT) has shown potential as a safe and convenient physical treatment method for patients with neurodegenerative disease. While some studies have reported limited or no effects, LT remains an attractive therapeutic approach for further investigation in ND. Further research through animal experiments and large clinical trials is needed to fully understand its mechanisms of action and true efficacy.
CHINESE MEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Nian Cao, Hui Tang, Miao Tian, Xue Gong, Zaicheng Xu, Binqing Zhou, Cong Lan, Caiyu Chen, Shuang Qu, Shuo Zheng, Hongmei Ren, Chao Fan, Pedro A. Jose, Chunyu Zeng, Tianyang Xia
Summary: This study found that hypertensive patients with GRK4 variants are more likely to be non-dippers and show a significantly better antihypertensive response to candesartan compared to those with GRK4 wild type.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Monica L. Guzman-Limon, Shuai Jiang, Derek Ng, Joseph T. Flynn, Bradley Warady, Susan L. Furth, Joshua A. Samuels
Summary: This study investigated the effects of nocturnal hypertension on the progression of chronic kidney disease (CKD) in children. The study found that children with both daytime and nocturnal hypertension had the highest risk of kidney replacement therapy. The study confirmed the utility of ambulatory blood pressure monitoring in children with CKD. Identifying and controlling both daytime and nocturnal hypertension using ambulatory blood pressure monitoring may improve outcomes and delay CKD progression in this population.
Article
Urology & Nephrology
Margriet E. Gosselink, Marleen C. van Buren, Judith Kooiman, Henk Groen, Wessel Ganzevoort, Henk W. van Hamersvelt, Olivier W. H. van der Heijden, Jacqueline van De Wetering, A. Titia Lely
Summary: Although the number of pregnancies after kidney transplantation is increasing, there are still high risks of adverse pregnancy outcomes. This study analyzed the outcomes of pregnancies after kidney transplantation based on pre-pregnancy estimated glomerular filtration rate-chronic kidney disease categories. It found that pre-pregnancy graft function and hemodynamic adaptation to pregnancy were the main factors affecting adverse outcomes.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Lamya Ghenim, Cedric Allier, Patricia Obeid, Lionel Herve, Jean-Yves Fortin, Maxim Balakirev, Xavier Gidrol
Summary: A new 4-hour ultradian rhythm has been discovered during the interphase of the cell cycle, detected in various individual mammalian cells using holographic lens-free microscopy. This rhythm is independent of the circadian rhythm, and provides a way to quantify the effects of chemical reagents on cells through the amplitude of the fundamental frequency. It represents a massive degradation and re-synthesis of protein every 4 hours in proliferating cells, and is suppressed by proteostasis disruptors.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Lauren G. Douma, Dominique Barral, Michelle L. Gumz
Summary: The peptide hormone endothelin-1 and its receptors are associated with various disease states, such as pulmonary hypertension. While pharmacological inhibition in pulmonary hypertension has been beneficial, further research is needed to leverage the intersection between endothelin signaling and circadian rhythm regulation for potential endothelin-based therapeutics.
Article
Cardiac & Cardiovascular Systems
Vibhu Parcha, Nirav Patel, Orlando M. Gutierrez, Peng Li, Karen L. Gamble, Kiran Musunuru, Kenneth B. Margulies, Thomas P. Cappola, Thomas J. Wang, Garima Arora, Pankaj Arora
Summary: This clinical trial investigated the diurnal rhythmicity of natriuretic peptides in healthy lean and obese individuals, revealing a misalignment of the NP-BP diurnal rhythm in the obese population.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Ecology
Jacobo Aguirre
Summary: Fitness landscapes are now shown to be more navigable than previously thought, where fitness maxima can be reached from almost any other phenotype while avoiding rare fitness valleys.
NATURE ECOLOGY & EVOLUTION
(2022)
News Item
Optics
Minkyu Kim, Vladimir V. Tsukruk
Summary: Terahertz spectroscopy has helped in identifying the chiral nature of phonons in crystals of biomolecules, leading to a better understanding of biochemical processes.
Article
Biochemistry & Molecular Biology
Tobias S. Kaiser, Jule Neumann
Summary: Circalunar clocks, allowing organisms to time reproduction to lunar phase, have been experimentally proven but are still not well understood at the molecular level. A new generation of researchers is using new tools to address this gap. Classic experiments on circalunar clocks highlight potential avenues for molecular research and suggest divergent mechanisms across different organisms.
