Journal
NATURE MEDICINE
Volume 15, Issue 10, Pages 1124-1125Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1009-1124
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Funding
- NIDCR NIH HHS [UL1 DE019587, UL1 DE019587-03] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [UL1DE019587] Funding Source: NIH RePORTER
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Imatinib (trade name Gleevec) preserves fertility in female mice treated with the common chemotherapeutic agent cisplatin. Imatinib seems to block an apoptotic pathway activated by cisplatin in ovarian germ cells (pages 1179-1185). The findings could lead to new ways to protect germ cells from the damaging effects of cancer treatment.
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