Article
Medicine, General & Internal
Yan Li, Natalie van Landeghem, Aydin Demircioglu, Martin Kohrmann, Philipp Dammann, Marvin Darkwah Oppong, Ramazan Jabbarli, Jens Matthias Theysohn, Jens-Christian Altenbernd, Hanna Styczen, Michael Forsting, Isabel Wanke, Benedikt Frank, Cornelius Deuschl
Summary: The study examined predictors of symptomatic intracranial hemorrhage (sICH) in acute ischemic stroke (AIS) patients after thrombectomy, finding that short procedure time and complete reperfusion were significantly associated with reduced sICH risk, while successful reperfusion did not necessarily lower sICH risk. Total ischemic time and intravenous thrombolysis were not predictors of sICH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jord J. T. Vink, Eline C. C. van Lieshout, Willem M. M. Otte, Ruben P. A. van Eijk, Mirjam Kouwenhoven, Sebastiaan F. W. Neggers, H. Bart van der Worp, Johanna M. A. Visser-Meily, Rick M. M. Dijkhuizen
Summary: Inhibitory repetitive transcranial magnetic stimulation treatment started within 3 weeks after stroke onset promotes upper limb motor recovery, reduces disability and dependence, and leads to earlier discharge from the rehabilitation center.
Review
Engineering, Biomedical
Shannon B. Lim, Dennis R. Louie, Sue Peters, Teresa Liu-Ambrose, Lara A. Boyd, Janice J. Eng
Summary: Investigations into real-time brain activations during walking post-stroke have shown differences in brain activation compared to healthy individuals, with different components of gait leading to different brain activations. Asymmetrical activations during gait were closely related to performance asymmetry, while hyperactivations often decreased with walking interventions and improved walking performance.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Biochemistry & Molecular Biology
Hui-min Gao, Hao Chen, Gui-Yun Cui, Jin-Xia Hu
Summary: This article briefly describes the role and mechanism of action of the blood-brain barrier (BBB), as well as the functional proteins involved. Additionally, it discusses the mechanisms of BBB damage following an ischemic stroke and presents several therapeutic strategies addressing these impairments. The article aims to provide innovative ideas for drug delivery research via the BBB.
CELL AND BIOSCIENCE
(2023)
Review
Cell Biology
Jana Krystofova Mike, Donna Marie Ferriero
Summary: Neonatal brain hypoxia-ischemia (HI) is a major cause of morbidity and long-term disabilities in children. Efferocytosis, the process of immune regulation and clearance of cellular debris, has therapeutic potential in neurodegenerative diseases and could be a promising target for new HI therapies after stroke.
Article
Multidisciplinary Sciences
Elissa L. Newport, Anna Seydell-Greenwald, Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers, Kelly C. Martin, Rebecca Rennert, Margot Giannetti, Alexander W. Dromerick, Rebecca N. Ichord, Jessica L. Carpenter, Madison M. Berl, William D. Gaillard
Summary: The mature human brain is lateralized for language, with the left hemisphere primarily responsible for sentence processing and the right hemisphere primarily responsible for processing suprasegmental aspects of language. It has been hypothesized that there is plasticity for language in early life, allowing young children to acquire language in other cortical regions when LH areas are damaged. This reorganization is highly constrained, with sentence processing almost always occurring in the right hemisphere frontotemporal regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Biology
S. Thomas Carmichael
Summary: Stimulating cortical areas in the undamaged hemisphere of a stroke-affected brain impairs recovery, according to a study in mice.
Article
Clinical Neurology
Awad Alzahrani, Xinyu Zhang, Adel Albukhari, Joanna M. Wardlaw, Grant Mair
Summary: This study aims to determine the threshold for brain attenuation on nonenhanced computed tomography (NECT) to differentiate CTP-defined penumbra vs core, and to correlate NECT features with CTP. The results showed that isolated swelling is highly specific to penumbra and can be differentiated by measuring lesion attenuation.
Article
Neuroimaging
Cathy Y. Yu, Peter D. Panagos, Akash P. Kansagra
Summary: This study quantified the real-world travel time and distance for different transport models for large-vessel occlusion (LVO) and non-LVO stroke patients. The results showed that bypass routing offers modest travel time benefits for LVO patients but incurs modest penalties for non-LVO patients. The differences are greatest in rural areas. The majority of Americans live in areas where current guidelines recommend bypass.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Juliette Tennenbaum, Matthieu Groh, Laura Venditti, France Campos-Gazeau, Emilie Chalayer, Thomas De Broucker, Mohamed Hamidou, Mathilde Hunault, Aicha Lyoubi, Raphaelle Meunier, Thierry Muron, Damien Sene, Borhane Slama, Celine Guidoux, Guillaume Lefevre, Jean-Emmanuel Kahn, Christian Denier, Julien Rohmer
Summary: Ischemic stroke has been reported in patients with F/P-associated clonal hypereosinophilic syndrome, and most cerebral imaging shows multiple bilateral infarctions of watershed distribution. Despite frequent cardiac involvement, only one patient had evidence of cardiac thrombus, and 62.5% of strokes were presumed to be of undetermined etiology according to the TOAST classification. After a median follow-up of 4.5 years, stroke recurred in only 3 out of 15 patients treated with imatinib.
Article
Endocrinology & Metabolism
Lukas Meyer, Michael Schoenfeld, Matthias Bechstein, Uta Hanning, Bastian Cheng, Goetz Thomalla, Gerhard Schoen, Andre Kemmling, Jens Fiehler, Gabriel Broocks
Summary: This study found that age is a significant factor in influencing brain edema formation after thrombectomy for LVO stroke. Younger patients showed higher edema formation on follow-up, while older patients had relatively lower levels. Successful recanalization reduced edema progression, but younger age remained independently associated with higher edema formation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Weijie Chen, Yueman Zhang, Xiaozhu Zhai, Lv Xie, Yunlu Guo, Chen Chen, Yan Li, Fajun Wang, Ziyu Zhu, Li Zheng, Jieqing Wan, Peiying Li
Summary: Stroke can cause neuronal death and disruption of brain structure, leading to secondary inflammatory injury. Microglia, as scavenger cells in the brain, play an important role in the clearance of cellular debris. However, they can also exacerbate neuronal loss by phagocytosing stressed-but-viable neurons. The optimal immune response requires a delicate balance between different phenotypic states to regulate neuro-inflammation and facilitate reconstruction after stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Sanne J. den Hartog, Hester F. Lingsma, Pieter-Jan van Doormaal, Jeannette Hofmeijer, Lonneke S. F. Yo, Charles B. L. M. Majoie, Diederik W. J. Dippel, Aad van der Lugt, Bob Roozenbeek
Summary: This study aimed to evaluate the variation in door-to-reperfusion time between and within Dutch intervention hospitals and analyze the contribution of different time intervals to this variation. The study found that there is variation in door-to-reperfusion time between hospitals and even more within hospitals. It also highlighted the importance of reducing variation between patients within a hospital and specifically focusing on CTA-to-groin time and groin-to-reperfusion time to improve stroke care quality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan Shah, Helen M. Dewey, Gagan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Bruce Cv Campbell
Summary: The relationship between reperfusion and edema in ischemic stroke patients with large vessel occlusion is complex. Core volume on pre-treatment CT-Perfusion is positively associated with edema, while mismatch volume has a significant interaction with reperfusion in influencing edema outcomes. Reperfusion appears to have a beneficial effect in reducing edema in patients with large mismatch volume but not in those with smaller mismatch volume.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Malin Dorvall, Annie Pedersen, Jan P. Dumanski, Martin Soderholm, Arne G. Lindgren, Tara M. Stanne, Christina Jern
Summary: This study found an association between mosaic loss of chromosome Y (LOY) in male patients and poor outcome after ischemic stroke, which remained significant in patients not receiving recanalization therapy. Further studies on LOY and other somatic genetic alterations in larger stroke cohorts are needed.