Translating materials design to the clinic

Neutral Polymeric Micelles for RNA Delivery

(2013) Brittany B. Lundy et al.   BIOCONJUGATE CHEMISTRY

Docetaxel Conjugate Nanoparticles That Target  -Smooth Muscle Actin-Expressing Stromal Cells Suppress Breast Cancer Metastasis

(2013) M. Murakami et al.   CANCER RESEARCH

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Peripherally Administered Nanoparticles Target Monocytic Myeloid Cells, Secondary Lymphoid Organs and Tumors in Mice

(2013) Iraklis C. Kourtis et al.   PLoS One

Self-Assembly of Thermally Responsive Nanoparticles of a Genetically Encoded Peptide Polymer by Drug Conjugation

(2012) Jonathan R. McDaniel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma

(2012) Kazuhira Endo et al.   CANCER SCIENCE

Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth

(2012) Mohammad Aminur Rahman et al.   JOURNAL OF CONTROLLED RELEASE

Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia

(2012) Jonathan R. McDaniel et al.   JOURNAL OF CONTROLLED RELEASE

Vascular-targeted photothermal therapy of an orthotopic murine glioma model

(2012) Emily S Day et al.   Nanomedicine

Combinatorial discovery of polymers resistant to bacterial attachment

(2012) Andrew L Hook et al.   NATURE BIOTECHNOLOGY

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

(2012) Bozhi Tian et al.   NATURE MATERIALS

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes

(2012) S. Padilla-Parra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanomaterials for Drug Delivery

(2012) J. A. Hubbell et al.   SCIENCE

First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip

(2012) R. Farra et al.   Science Translational Medicine

Vascular Catheters with a Nonleaching Poly-Sulfobetaine Surface Modification Reduce Thrombus Formation and Microbial Attachment

(2012) R. S. Smith et al.   Science Translational Medicine

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Nanoparticle Delivery of Cancer Drugs

(2011) Andrew Z. Wang et al.   Annual Review of Medicine

Diblock copolymers with tunable pH transitions for gene delivery

(2011) Matthew J. Manganiello et al.   BIOMATERIALS

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours

(2011) R Plummer et al.   BRITISH JOURNAL OF CANCER

Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer

(2011) Ken Kato et al.   INVESTIGATIONAL NEW DRUGS

Nanoparticles that communicate in vivo to amplify tumour targeting

(2011) Geoffrey von Maltzahn et al.   NATURE MATERIALS

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Nanowired three-dimensional cardiac patches

(2011) Tal Dvir et al.   Nature Nanotechnology

Bio-inspired, bioengineered and biomimetic drug delivery carriers

(2011) Jin-Wook Yoo et al.   NATURE REVIEWS DRUG DISCOVERY

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

(2011) C. Nembrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting

(2011) M. Murakami et al.   Science Translational Medicine

Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer

(2010) Day   International Journal of Nanomedicine

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-Infrared-Resonant Gold/Gold Sulfide Nanoparticles as a Photothermal Cancer Therapeutic Agent

(2010) André M. Gobin et al.   Small

A New Era for Cancer Treatment: Gold-Nanoparticle-Mediated Thermal Therapies

(2010) Laura C. Kennedy et al.   Small

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

(2009) J. Andrew MacKay et al.   NATURE MATERIALS

Development of a novel endosomolytic diblock copolymer for siRNA delivery

(2008) Anthony J. Convertine et al.   JOURNAL OF CONTROLLED RELEASE

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY