The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
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Title
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance
Authors
Keywords
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Journal
NATURE IMMUNOLOGY
Volume 15, Issue 3, Pages 258-265
Publisher
Springer Nature America, Inc
Online
2014-01-27
DOI
10.1038/ni.2820
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- Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?
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- The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
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- Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
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- Transcriptional impact of Aire varies with cell type
- (2008) M. Guerau-de-Arellano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity
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