The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells

Human ITCH E3 Ubiquitin Ligase Deficiency Causes Syndromic Multisystem Autoimmune Disease

(2010) Naomi J. Lohr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

Controlling stem cell fate one substrate at a time

(2010) Brian S Garrison et al.   NATURE IMMUNOLOGY

Mechanisms of Stem Cell Self-Renewal

(2009) He Shenghui et al.   Annual Review of Cell and Developmental Biology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Balancing dormant and self-renewing hematopoietic stem cells

(2009) Anne Wilson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The hematopoiesis paradigm: clarity or ambiguity?

(2008) C. Rathinam et al.   BLOOD

Itch-/-   and    T cells independently contribute to autoimmunity in Itchy mice

(2008) V. Parravicini et al.   BLOOD

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells

(2008) Irene M. Min et al.   Cell Stem Cell

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase

(2008) T. Yokomizo et al.   GENES & DEVELOPMENT

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells

(2008) C. Rathinam et al.   GENES & DEVELOPMENT

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

(2008) K Venuprasad et al.   NATURE IMMUNOLOGY

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

(2008) Patricia Chastagner et al.   PLoS One

Signaling pathways governing stem-cell fate

(2007) U. Blank et al.   BLOOD