4.7 Editorial Material

Beyond peptidoglycan for Nod2

Journal

NATURE IMMUNOLOGY
Volume 10, Issue 10, Pages 1053-1054

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ni1009-1053

Keywords

-

Categories

Ask authors/readers for more resources

Nod2 is a cytoplasmic Nod-like receptor protein that detects the peptidoglycan subfragment muramyl dipeptide. New work shows that Nod2 also has an important role in recognizing viruses and in triggering interferon production during viral infection.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Medicine, Research & Experimental

Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation

Matthias Laengin, Bruno Reichart, Stig Steen, Trygve Sjoberg, Audrius Paskevicius, Qiuming Liao, Guangqi Qin, Maren Mokelke, Tanja Mayr, Julia Radan, Lara Issl, Ines Buttgereit, Jiawei Ying, Ann Kathrin Fresch, Alessandro Panelli, Stefanie Egerer, Andrea Baehr, Barbara Kessler, Anastasia Milusev, Riccardo Sfriso, Robert Rieben, David Ayares, Peter J. Murray, Reinhard Ellgass, Christoph Walz, Nikolai Klymiuk, Eckhard Wolf, Jan-Michael Abicht, Paolo Brenner

Summary: The preservation technique of cold non-ischemic perfusion effectively prevented early graft failure in porcine hearts transplanted into baboons, while the traditional cold ischemic cardioplegia technique led to perioperative cardiac xenograft dysfunction.

XENOTRANSPLANTATION (2021)

Article Biology

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

Leonie Zeitler, Alessandra Fiore, Claudia Meyer, Marion Russier, Gaia Zanella, Sabine Suppmann, Marco Gargaro, Sachdev S. Sidhu, Somasekar Seshagiri, Caspar Ohnmacht, Thomas Kocher, Francesca Fallarino, Andreas Linkermann, Peter J. Murray

Summary: IL4i1 is an amino acid oxidase that inhibits ferroptotic oxidative cell death by generating I3P from tryptophan, thus activating a cell protective gene expression program.

ELIFE (2021)

Article Biochemistry & Molecular Biology

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

Chiara Musiu, Simone Caligola, Alessandra Fiore, Alessia Lamolinara, Cristina Frusteri, Francesco Domenico Del Pizzo, Francesco De Sanctis, Stefania Cane, Annalisa Adamo, Francesca Hofer, Roza Maria Barouni, Andrea Grilli, Serena Zilio, Paolo Serafini, Evelina Tacconelli, Katia Donadello, Leonardo Gottin, Enrico Polati, Domenico Girelli, Ildo Polidoro, Piera Amelia Iezzi, Domenico Angelucci, Andrea Capece, Ying Chen, Zheng-Li Shi, Peter J. Murray, Marco Chilosi, Ido Amit, Silvio Bicciato, Manuela Iezzi, Vincenzo Bronte, Stefano Ugel

Summary: Research has shown that FLIP can control cytokine release syndrome (CRS) by activating a STAT3-dependent inflammatory program. Expression of a viral FLIP homolog in myeloid cells can trigger a fatal inflammatory syndrome in mice, characterized by increased cytokine output, lymphopenia, lung injury, and multiple organ dysfunctions. Targeting the STAT3 pathway may help alleviate inflammation, immune disorders, and organ failures associated with CRS.

CELL DEATH AND DIFFERENTIATION (2022)

Article Allergy

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma

Antonie Lechner, Fiona D. R. Henkel, Franziska Hartung, Sina Bohnacker, Francesca Alessandrini, Ekaterina O. Gubernatorova, Marina S. Drutskaya, Carlo Angioni, Yannick Schreiber, Pascal Haimerl, Yan Ge, Dominique Thomas, Agnieszka M. Kabat, Edward J. Pearce, Caspar Ohnmacht, Sergei A. Nedospasov, Peter J. Murray, Adam M. Chaker, Carsten B. Schmidt-Weber, Julia Esser-von Bieren

Summary: This study reveals the existence of macrophage-trained immunity in allergic asthma, characterized by inflammatory transcriptional reprogramming and excessive mediator responses. Allergen-triggered inflammation drives a TNF-dependent innate memory, which may perpetuate and exacerbate chronic type 2 airway inflammation and thus represents a target for asthma therapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Article Cell Biology

Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

Fei Chen, Darine W. El-Naccache, John J. Ponessa, Alexander Lemenze, Vanessa Espinosa, Wenhui Wu, Katherine Lothstein, Linhua Jin, Olivia Antao, Jason S. Weinstein, Payal Damani-Yokota, Kamal Khanna, Peter J. Murray, Amariliz Rivera, Mark C. Siracusa, William C. Gause

Summary: This study reveals that recruited monocytes differentiate into an alveolar macrophage-like phenotype in the lung after infection with the nematode parasite. These monocyte-derived macrophages express high levels of arginase-1, which mediates helminth killing through arginine depletion.

CELL REPORTS (2022)

Article Biology

Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF

Stefanie Dichtl, David E. Sanin, Carolin K. Koss, Sebastian Willenborg, Andreas Petzold, Maria C. Tanzer, Andreas Dahl, Agnieszka M. Kabat, Laura Lindenthal, Leonie Zeitler, Sabrina Satzinger, Alexander Strasser, Matthias Mann, Axel Roers, Sabine A. Eming, Karim C. El Kasmi, Edward J. Pearce, Peter J. Murray

Summary: Anti-TNF therapies can protect against chronic diseases by modulating the balance of macrophage activity, specifically regulating components of tissue and reparative M2 macrophages.

LIFE SCIENCE ALLIANCE (2022)

Article Biochemistry & Molecular Biology

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

Alessandra Fiore, Leonie Zeitler, Marion Russier, Annette Gross, Maria-Kathrin Hiller, Joanne L. Parker, Luca Stier, Thomas Kocher, Simon Newstead, Peter J. Murray

Summary: This study uncovers an unrecognized link between IDO1 and cell survival mediated by KYN, which inhibits ferroptotic cell death. The findings highlight the need to re-evaluate the use of IDO1 inhibitors in cancer treatment.

MOLECULAR CELL (2022)

Biographical-Item Oncology

OBITUARY Ursula Grohmann, PhD: In Memoriam (1961-2022)

Vincenzo Bronte, Laura Santambrogio, Peter J. Murray

CANCER IMMUNOLOGY RESEARCH (2022)

Article Immunology

Monocytes Elicit a Neutrophil-Independent Th1/Th17 Response Upon Immunization With a Mincle-Dependent Glycolipid Adjuvant

Christiane Desel, Peter J. Murray, Christian H. K. Lehmann, Lukas Heger, Dennis Christensen, Peter Andersen, Matthias Mack, Diana Dudziak, Roland Lang

Summary: This study investigated the recruitment of monocytes and neutrophils to the site of injection and draining lymph nodes after vaccination with the TDB-containing adjuvant CAF01 in a protein-based vaccine. Monocytes and neutrophils played different roles in adjuvant-stimulated Th1/Th17 responses.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

A common framework of monocyte-derived macrophage activation

David E. Sanin, Yan Ge, Emilija Marinkovic, Agnieszka M. Kabat, Angela Castoldi, George Caputa, Katarzyna M. Grzes, Jonathan D. Curtis, Elizabeth A. Thompson, Sebastian Willenborg, Stefanie Dichtl, Susanne Reinhardt, Andreas Dahl, Erika L. Pearce, Sabine A. Eming, Alexander Gerbaulet, Axel Roers, Peter J. Murray, Edward J. Pearce

Summary: Macrophages display heterogeneity and different activation patterns in different organs and inflammatory conditions. By building a predictive model, we identified four conserved activation paths for macrophages. This integrative classification approach helps us understand and predict the activation patterns of macrophages in inflammation and homeostasis.

SCIENCE IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling

Johanna B. Brueggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Broetzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan E. Eickhoff, Peter J. Murray

Summary: mTORC1 and GCN2 are kinases that control how cells adapt to amino acid availability. Inhibitors of mTOR kinase can concurrently inhibit different branches of amino acid sensing, including inhibiting GCN2 activation, by affecting the translation machinery.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Article Medicine, Research & Experimental

Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever

Lisa Kohl, Md Nur A. Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Oelke, Elisabeth Liebler-Tenorio, Jan Schulze-Luehrmann, Michael Mauermeir, Kai-Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Kroenke, Peter J. Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens-Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Luehrmann, Roland Lang

Summary: Infection with Coxiella burnetii can cause chronic Q fever with severe complications and limited treatment options. In this study, it was found that the enzyme ACOD1 and its product itaconate play a protective role in the host immune response against Q fever. ACOD1 was essential for restricting C. burnetii replication, and exogenously added itaconate restored pathogen control in mouse and human macrophages.

EMBO MOLECULAR MEDICINE (2023)

Article Cell Biology

Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung-Jin Chung, Triantafyllos Chavakis, Eva Griesser, Praveen Baskaran, Ulrike Maier-Habelsberger, Katrin Fundel-Clemens, Ines Schlotthauer, Carolin Kirsten Watson, Lee Kim Swee, Frederik Igney, John Edward Park, Markus S. Huber-Lang, Matthew-James Thomas, Karim Christian El Kasmi, Peter J. Murray

Summary: Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. Through this study, it was found that senescent cells not only inhibit the engulfment and removal ability of macrophages, but also paralyze their ability to clear bystander apoptotic cells. This suppression is achieved through direct contact between senescent cells and macrophages. Furthermore, CD47 and CD24 proteins are closely related to this process.

JOURNAL OF CELL BIOLOGY (2022)

Article Biology

Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation

Dawafuti Sherpa, Judith Mueller, Oezge Karayel, Peng Xu, Yu Yao, Jakub Chrustowicz, Karthik Gottemukkala, Christine Baumann, Annette Gross, Oliver Czarnecki, Wei Zhang, Jun Gu, Johan Nilvebrant, Sachdev S. Sidhu, Peter J. Murray, Matthias Mann, Mitchell J. Weiss, Brenda A. Schulman, Arno F. Alpi

Summary: This study measured the proteomic landscape of in vitro human erythropoiesis models and found dynamic differential expression of subunits of the CTLH E3 ubiquitin ligase complex, as well as changes in the protein abundance of UBE2H. Inactivation of CTLH E3 assemblies or UBE2H led to defects in erythroid progenitors, including accelerated maturation and inefficient enucleation. These findings suggest that dynamic changes in UBE2H-CTLH E2-E3 modules control the orderly progression of human erythropoiesis.

ELIFE (2022)

Article Biochemistry & Molecular Biology

Activity-based profiling of cullin-RING E3 networks by conformation-specific probes

Lukas T. Henneberg, Jaspal Singh, David M. Duda, Kheewoong Baek, David Yanishevski, Peter J. Murray, Matthias Mann, Sachdev S. Sidhu, Brenda A. Schulman

Summary: Researchers have developed conformation-specific antibodies to probe the NEDD8-activated cullin-RING ubiquitin E3 ligase networks in mammalian cells in response to extracellular stimuli, metabolic signals, and degrader drugs.

NATURE CHEMICAL BIOLOGY (2023)

No Data Available