Journal
NATURE IMMUNOLOGY
Volume 10, Issue 10, Pages 1049-1051Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1009-1049
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Cytosolic DNA sensors have remained poorly defined so far. Two recent studies identify a previously undefined cytosolic DNA-sensing pathway that depends on the RNA polymerase III-mediated conversion of microbial DNA into 5'-triphosphate double-stranded RNA that activates the RNA helicase RIG-I.
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