4.7 Editorial Material

The Foxo and the hound: chasing the in vivo regulation of T cell populations during infection

Journal

NATURE IMMUNOLOGY
Volume 10, Issue 5, Pages 457-458

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ni0509-457

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Funding

  1. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI042334] Funding Source: NIH RePORTER
  2. NIAID NIH HHS [R01 AI042334] Funding Source: Medline

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T cell expansion and contraction during the immune response to pathogens are regulated by a wide variety of cell-intrinsic and cell-extrinsic factors. A new study identifies a role for CTLA-4 signaling and activation of the Foxo3 transcription factor in modulating T cell populations.

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