4.7 Editorial Material

Lymphocyte transmigration in the brain: a new way of thinking

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NATURE IMMUNOLOGY
Volume 9, Issue 2, Pages 117-118

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NATURE PUBLISHING GROUP
DOI: 10.1038/ni0208-117

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Lymphocytes depend on endothelial adhesion molecules such as ICAM-1 and VCAM-1, upregulated with inflammation, to facilitate transmigration across junctional barriers. New data show that ALCAM replaces VCAM-1 in the CNS during the development of neuroinflammatory diseases such as multiple sclerosis.

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