Journal
NATURE GENETICS
Volume 46, Issue 3, Pages 214-215Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2904
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Funding
- Intramural NIH HHS [ZIA BC011028-06, ZIA BC011038-06] Funding Source: Medline
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Clear cell renal cell carcinoma (CCRCC) is characterized by mutation of the VHL gene and loss of a segment of chromosome 3. A new study using multi-region exome sequencing has identified substantial intratumoral heterogeneity within large primary CCRCCs, which has profound implications for understanding tumor evolution and for developing effective therapies.
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